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Cited by 121Schizophrenia research and treatmentSexual function and dysfunction studiesMental Health and Psychiatry

Effects of atypical and typical antipsychotic treatments on sexual function in patients with schizophrenia: 12-month results from the Intercontinental Schizophrenia Outpatient Health Outcomes (IC-SOHO) study

Dossenbach, Martin, Dyachkova, Yulia, Pirildar, Sebnem, Anders, Martin, Khalil, Afaf, Araszkiewicz, Aleksander, Shakhnovich, Tamara, Akram, Aly +3 more·2006·European Psychiatry
DOI 10.1016/j.eurpsy.2005.12.005
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Abstract

Purpose: Sexual dysfunction in patients with schizophrenia can reduce quality of life and treatment compliance. This report will compare the effects of selected atypical and typical antipsychotics on sexual function in a large, international population of outpatients with schizophrenia who were treated over 1 year. Subjects and methods: Outpatients with schizophrenia, who initiated or changed antipsychotic treatment, and entered this 3-year, prospective, observational study were classified according to the monotherapy prescribed at baseline: olanzapine (N = 2638), risperidone (N = 860), quetiapine (N = 142) or haloperidol (N = 188). Results: Based on patient perception, the odds of experiencing sexual dysfunction during 1 year of therapy was significantly lower for patients treated with olanzapine and quetiapine when compared to patients who received risperidone or haloperidol (all P ≤ 0.001). Females on olanzapine (14%) or quetiapine (8%) experienced a lower rate of menstrual irregularities, compared to females on risperidone (23%) or haloperidol (29%). Significant discordance was evident between patient reports and psychiatrist perception of sexual dysfunction, with psychiatrists underestimating sexual dysfunction (P ≤ 0.001). Conclusions: These findings indicate clinically relevant differences exist in the sexual side effect profiles of these selected antipsychotics. These factors should be considered when selecting the most appropriate treatment for outpatients with schizophrenia.

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Authors
Dossenbach, M., Dyachkova, Y., Pirildar, S., Anders, M., Khalil, A., Araszkiewicz, A., Shakhnovich, T., Akram, A., Pecenak, J., McBride, M., & Treuer, T.
Affiliations
  • Charles University (CZ)
  • Ain Shams University Hospital (EG)
  • Soliman Fakeeh Hospital (SA)
  • Eli Lilly (Australia) (AU)
Corresponding author
Dossenbach, Martin
ORCID
Venue
European Psychiatry
Publisher
Cambridge University Press (CUP)
Published
2006-06
Volume
21
Issue
4
Pages
251-258
ISSN
  • 0924-9338 (ISSN-L)
  • 1778-3585
DOI
10.1016/j.eurpsy.2005.12.005
OpenAlex
W2038782032
Cited by
121
References
28
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 4 · 2021: 3 · 2020: 3 · 2019: 9 · 2018: 1 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 4 · 2013: 5 · 2012: 11
FWCI
8.07
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 5068 d)
Locations
  • European Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
schizophrenia, sexual dysfunction, antipsychotic drugs, atypical antipsychotics, typical antipsychotics, olanzapine, risperidone, quetiapine, haloperidol, menstrual irregularity, patient-reported outcomes, physician perceptions, outpatients, treatment side effects
MeSH terms
Quetiapine Fumarate, Olanzapine, Adult, Analysis of Variance, Benzodiazepines, Dibenzothiazepines, Female, Haloperidol, Health Surveys, Humans, Male, Outpatients, Prospective Studies, Schizophrenia, Sexual Dysfunction, Physiological, Time, Antipsychotic Agents, Prevalence, Odds Ratio, Treatment Outcome, Risperidone

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