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Oxytocin receptor polymorphisms and adult attachment style in patients with depression
Abstract
Much evidence of an association between specific attachment styles and depression prompted us to investigate, in depressive disorders, the potential role of polymorphisms within the gene encoding the receptor of the main neurohormone involved in attachment processes, oxytocin. For this purpose, two single nucleotide polymorphisms (SNPs), 6930G>A (rs53576) and 9073G>A (rs2254298), within the oxytocin receptor gene (OXTR), were studied in a cohort of 185 patients with major depression (50.3%) or bipolar I or II disorders (49.7%) and 192 matched healthy controls. A positive association between the GG genotype of OXTR SNPs (6930G>A or 9073G>A) and unipolar depression was demonstrated. In this group, GG individuals showed high scores on Attachment Style Questionnaire factors that have been previously associated with depression. Moreover, the GG genotype was also associated with high levels of adult separation anxiety. These findings support the involvement of the oxytocinergic system in the mechanisms that underlie depression and specific adult attachment styles.
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“individuals homozygous for the G allele for the SNPS rs53576 and rs2254298 exhibited higher scores on Attachment Style Questionnaire factors that are associated with depression and adult separation anxiety (Costa et al., 2009).”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Costa et al., 2009
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Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455
A Rating Scale for Mania: Reliability, Validity and Sensitivity
Young, R. C., Biggs, J. T., Ziegler, V. E., & Meyer, D. A. (1978) · British Journal of Psychiatry · doi:10.1192/bjp.133.5.429 · Cited by 8,744
Romantic love conceptualized as an attachment process.
Hazan, C., & Shaver, P. (1987) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.52.3.511 · Cited by 6,247
Attachment styles among young adults: A test of a four-category model.
Bartholomew, K., & Horowitz, L. M. (1991) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.61.2.226 · Cited by 6,009
Attachment in adulthood: structure, dynamics, and change
(2008) · Choice Reviews Online · doi:10.5860/choice.45-2903 · Cited by 4,303
(1998) · Cited by 3,968
Attachment theory and close relationships
(1998) · Choice Reviews Online · doi:10.5860/choice.35-6513 · Cited by 3,642
A Comparison of Bayesian Methods for Haplotype Reconstruction from Population Genotype Data
Stephens, M., & Donnelly, P. (2003) · The American Journal of Human Genetics · doi:10.1086/379378 · Cited by 3,516
Models of the self and other: Fundamental dimensions underlying measures of adult attachment.
Griffin, D. W., & Bartholomew, K. (1994) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.67.3.430 · Cited by 1,881
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Jurek, B., & Neumann, I. D. (2018) · Physiological Reviews · doi:10.1152/physrev.00031.2017 · Cited by 999
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Tost, H., Kolachana, B., Hakimi, S., Lemaitre, H., Verchinski, B. A., Mattay, V. S., Weinberger, D. R., & Meyer–Lindenberg, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003296107 · Cited by 564
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“Furthermore, individuals homozygous for the G allele for the SNPS rs53576 and rs2254298 exhibited higher scores on Attachment Style Questionnaire factors that are associated with depression and adult separation anxiety (Costa et al., 2009).”
Background
Metadata
- Authors
- Costa, B., Pini, S., Gabelloni, P., Abelli, M., Lari, L., Cardini, A., Muti, M., Gesi, C., Landi, S., Galderisi, S., Mucci, A., Lucacchini, A., Cassano, G. B., & Martini, C.
- Affiliations
- University of Pisa (IT)
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 34
- Issue
- 10
- Pages
- 1506-1514
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2149861656
- Cited by
- 282
- References
- 51
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 2 · 2023: 50 · 2022: 9 · 2021: 18 · 2020: 13 · 2019: 5 · 2018: 13 · 2017: 20 · 2016: 21 · 2015: 29 · 2014: 19 · 2013: 25 · 2012: 18
- FWCI
- 20.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
- Funders
- Università di Pisa
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin receptor gene, OXTR polymorphisms, adult attachment styles, major depressive disorder, bipolar disorder, single nucleotide polymorphisms, rs53576, rs2254298, separation anxiety, oxytocinergic system, genetic susceptibility to depression
- MeSH terms
- Adult, Anxiety, Separation, Female, Humans, Male, Object Attachment, RNA Splicing, Linkage Disequilibrium, Case-Control Studies, Receptors, Oxytocin, Mood Disorders, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide
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