Cited by 282Neuroendocrine regulation and behaviorAttachment and Relationship DynamicsNeurotransmitter Receptor Influence on Behavior

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Oxytocin receptor polymorphisms and adult attachment style in patients with depression

Costa, Barbara, Pini, Stefano, Gabelloni, Pamela, Abelli, Marianna, Lari, Lisa, Cardini, Alessandra, Muti, Matteo, Gesi, Camilla, Landi, Stefano, Galderisi, Silvana, Mucci, Armida, Lucacchini, Antonio, Cassano, Giovanni B., Martini, Claudia·2009·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2009.05.006

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Abstract

Much evidence of an association between specific attachment styles and depression prompted us to investigate, in depressive disorders, the potential role of polymorphisms within the gene encoding the receptor of the main neurohormone involved in attachment processes, oxytocin. For this purpose, two single nucleotide polymorphisms (SNPs), 6930G>A (rs53576) and 9073G>A (rs2254298), within the oxytocin receptor gene (OXTR), were studied in a cohort of 185 patients with major depression (50.3%) or bipolar I or II disorders (49.7%) and 192 matched healthy controls. A positive association between the GG genotype of OXTR SNPs (6930G>A or 9073G>A) and unipolar depression was demonstrated. In this group, GG individuals showed high scores on Attachment Style Questionnaire factors that have been previously associated with depression. Moreover, the GG genotype was also associated with high levels of adult separation anxiety. These findings support the involvement of the oxytocinergic system in the mechanisms that underlie depression and specific adult attachment styles.

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Authors: Costa, B., Pini, S., Gabelloni, P., Abelli, M., Lari, L., Cardini, A., Muti, M., Gesi, C., Landi, S., Galderisi, S., Mucci, A., Lucacchini, A., Cassano, G. B., & Martini, C.
Affiliations: University of Pisa (IT)
ORCID: Costa, Barbara
Pini, Stefano
Abelli, Marianna
Lari, Lisa
Gesi, Camilla
Landi, Stefano
Galderisi, Silvana
Mucci, Armida
Lucacchini, Antonio
Martini, Claudia
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2009-11
Volume: 34
Issue: 10
Pages: 1506-1514
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2009.05.006
OpenAlex: W2149861656
Cited by: 282
References: 51
Citations by year: 2026: 6 · 2025: 5 · 2024: 2 · 2023: 50 · 2022: 9 · 2021: 18 · 2020: 13 · 2019: 5 · 2018: 13 · 2017: 20 · 2016: 21 · 2015: 29 · 2014: 19 · 2013: 25 · 2012: 18
FWCI: 20.46
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
Archivio Istituzionale della Ricerca - Università degli Studi della Campania "Luigi Vanvitelli" (submittedVersion)
Funders: Università di Pisa
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Social Sciences › Psychology › Social Psychology › Attachment and Relationship Dynamics
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: oxytocin receptor gene, OXTR polymorphisms, adult attachment styles, major depressive disorder, bipolar disorder, single nucleotide polymorphisms, rs53576, rs2254298, separation anxiety, oxytocinergic system, genetic susceptibility to depression
MeSH terms: Adult, Anxiety, Separation, Female, Humans, Male, Object Attachment, RNA Splicing, Linkage Disequilibrium, Case-Control Studies, Receptors, Oxytocin, Mood Disorders, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide

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Oxytocin receptor polymorphisms and adult attachment style in patients with depression

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