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Cited by 25Regulation of Appetite and ObesityHypothalamic control of reproductive hormonesDietary Effects on Health

Meal anticipation potentiates postprandial ghrelin suppression in humans

Ott, Volker, Friedrich, Monique, Zemlin, Janna, Lehnert, Hendrik, Schultes, Bernd, Born, Jan, Hallschmid, Manfred·2012·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2011.10.007
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Abstract

Circulating concentrations of the orexigenic hormone ghrelin show a postprandial decrease in dependence on meal size and composition. Cognitive determinants of postprandial ghrelin suppression in humans are largely unexplored. We assessed the effects of cued meal anticipation on pre- and postprandial concentrations of total plasma ghrelin, pancreatic polypeptide and leptin as well as on markers of glucose metabolism in healthy men. In a between-subject comparison, meal anticipation was induced in 14 fasted men at 08:00 h by the announcement and subsequent presentation of a breakfast buffet. Fifteen fasted control subjects were informed that they would remain fasted until noon. At 10:00 h, both groups were served a rich free-choice breakfast. At 12:00 h, all subjects underwent a snack test assessing casual cookie intake. Circulating concentrations of ghrelin, pancreatic polypeptide, glucose, insulin and leptin were frequently assessed. Preprandial endocrine parameters as well as breakfast intake (all p>0.23) and subsequent snack consumption (p>0.83) were comparable between groups. The postprandial suppression of ghrelin levels observed in both groups was markedly stronger in subjects who had anticipated breakfast intake (p<0.03) while pancreatic polypeptide concentrations did not differ between groups (p>0.56). Results indicate that meal anticipation is a critical determinant of postprandial ghrelin suppression that, as suggested by unaltered pancreatic polypeptide levels, appears to be mediated independent of vagal activation. Our findings highlight the role of subtle cognitive factors in the postprandial regulation of ghrelin secretion, suggesting that neurobehavioral approaches to improved food intake control should take into account meal anticipatory mechanisms.

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Crossref · 10.1016/j.psyneuen.2011.10.007

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  • The free-choice ad libitum test buffet enables precise assessment of primarily hunger-driven food intake in the fasted state.

    “This procedure has been repeatedly shown to enable the precise assessment of primarily hunger-driven food intake in the fasted state (20–22).”

    From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [22]

  • The snack test assesses reward-related eating in the absence of hunger.

    “Reward-related eating in the absence of hunger was assessed using a snack test validated in a series of previous studies (22–24).”

    From Oxytocin Reduces Reward-Driven Food Intake in Humans (2013) · cites this paper as [22]

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Authors
Ott, V., Friedrich, M., Zemlin, J., Lehnert, H., Schultes, B., Born, J., & Hallschmid, M.
Affiliations
  • University of Lübeck (DE)
  • Kantonsspital St. Gallen (CH)
Corresponding author
Ott, Volker
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2012-07
Volume
37
Issue
7
Pages
1096-1100
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2011.10.007
OpenAlex
W2008286714
Cited by
25
References
14
Citations by year
2026: 3 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 6 · 2018: 3 · 2017: 1 · 2016: 1 · 2015: 2 · 2013: 2
FWCI
0.30
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Deutsche Forschungsgemeinschaft
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Physiology › Dietary Effects on Health
Keywords
ghrelin, pancreatic polypeptide, leptin, insulin, glucose metabolism, food intake regulation, vagal activation
MeSH terms
Adolescent, Adult, Blood Glucose, Circadian Rhythm, Eating, Food, Humans, Insulin, Male, Time Factors, Down-Regulation, Single-Blind Method, Postprandial Period, Leptin, Ghrelin, Young Adult, Anticipation, Psychological

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