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Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks
Open accessAbstract
Endocannabinoid (eCB) signaling has been identified as a modulator of adaptation to stress, and is integral to basal and stress-induced glucocorticoid regulation. Furthermore, interactions between eCBs and glucocorticoids have been shown to be necessary for the regulation of emotional memories, suggesting that eCB function may relate to the development of post-traumatic stress disorder (PTSD). To examine this, plasma eCBs were measured in a sample (n=46) drawn from a population-based cohort selected for physical proximity to the World Trade Center (WTC) at the time of the 9/11 attacks. Participants received a structured diagnostic interview and were grouped according to whether they met diagnostic criteria for PTSD (no PTSD, n=22; lifetime diagnosis of PTSD=24). eCB content (2-arachidonoylglycerol (2-AG) and anandamide (AEA)) and cortisol were measured from 8 a.m. plasma samples. Circulating 2-AG content was significantly reduced among individuals meeting diagnostic criteria for PTSD. The effect of reduced 2-AG content in PTSD remained significant after controlling for the stress of exposure to the WTC collapse, gender, depression and alcohol abuse. There were no significant group differences for AEA or cortisol levels; however, across the whole sample AEA levels positively correlated with circulating cortisol, and AEA levels exhibited a negative relationship with the degree of intrusive symptoms within the PTSD sample. This report shows that PTSD is associated with a reduction in circulating levels of the eCB 2-AG. Given the role of 2-AG in the regulation of the stress response, these data support the hypothesis that deficient eCB signaling may be a component of the glucocorticoid dysregulation associated with PTSD. The negative association between AEA levels and intrusive symptoms is consistent with animal data indicating that reductions in AEA promote retention of aversive emotional memories. Future work will aim to replicate these findings and extend their relevance to clinical pathophysiology, as well as to neuroendocrine and molecular markers of PTSD.
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“AEA levels have been shown to be reduced in PTSD patients (Hill et al., 2013;Neumeister et al., 2013) and depressed patients with high anxiety scores (Hill, Miller, Carrier, Gorzalka, & Hillard, 2009;Hill, Miller, Ho, Gorzalka, & Hillard, 2008).”
From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Hill et al., 2013
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Self-citationStructured Clinical Interview for DSM-IV (SCID)
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Self-citationEnhancing Cannabinoid Neurotransmission Augments the Extinction of Conditioned Fear
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Self-citationNeurobiological Interactions Between Stress and the Endocannabinoid System
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Metadata
- Authors
- Hill, M. N., Bierer, L. M., Makotkine, I., Golier, J. A., Galea, S., McEwen, B. S., Hillard, C. J., & Yehuda, R.
- Affiliations
- University of Calgary (CA)
- James J. Peters VA Medical Center (US)
- Columbia University (US)
- Rockefeller University (US)
- Medical College of Wisconsin (US)
- Corresponding author
- Hill, Matthew N.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 38
- Issue
- 12
- Pages
- 2952-2961
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC3870889
- OpenAlex
- W2024564598
- Cited by
- 256
- References
- 56
- Citations by year
- 2026: 8 · 2025: 27 · 2024: 24 · 2023: 22 · 2022: 15 · 2021: 28 · 2020: 24 · 2019: 22 · 2018: 28 · 2017: 16 · 2016: 10 · 2015: 19 · 2014: 10 · 2013: 2
- FWCI
- 10.03
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Canadian Institutes of Health Research
- National Institute of Mental Health (MH-41256, R37MH041256, R01MH041256, R56MH077321)
- National Institute on Drug Abuse (R01DA026996, DA026996)
- National Center for Research Resources (5 M01RR00071, M01RR000071)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- post-traumatic stress disorder, endocannabinoids, 2-arachidonoylglycerol, anandamide, cortisol, September 11 attacks, World Trade Center, intrusion symptoms, emotional memory, stress response, plasma biomarkers
- MeSH terms
- Aged, Alcoholism, Amides, Arachidonic Acids, Ethanolamines, Ethnicity, Female, Glycerides, Humans, Hydrocortisone, Male, Middle Aged, Neuropsychological Tests, Oleic Acids, Palmitic Acids, Psychiatric Status Rating Scales, Sex Characteristics, Stress Disorders, Post-Traumatic, Terrorism, Polyunsaturated Alkamides, Endocannabinoids
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