Enzymatic pathways that regulate endocannabinoid signaling in the nervous system
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ADVERTISEMENT RETURN TO ISSUEPREVReviewsNEXTEnzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous SystemKay Ahn, *†, Michele K. McKinney, ‡, and Benjamin F. Cravatt, *‡View Author Information Pfizer Global Research and Development, Groton, Connecticut 06340, and The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California 92037* To whom correspondence should be addressed. E-mail addresses: [email protected]; [email protected]†Pfizer Global Research and Development.‡The Scripps Research Institute.Cite this: Chem. Rev. 2008, 108, 5, 1687–1707Publication Date (Web):April 23, 2008Publication History Received28 January 2008Published online23 April 2008Published inissue 1 May 2008https://pubs.acs.org/doi/10.1021/cr0782067https://doi.org/10.1021/cr0782067review-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views3737Altmetric-Citations417LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Central nervous system,Inhibitors,Lipids,Peptides and proteins,Rodent models Get e-Alerts
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Tonic ECB signaling in the BLA and elsewhere is mediated by AEA, whereas phasic ECB responses to robust neuronal activation are sub-served by 2-AG.
“There is growing evidence that tonic ECB signaling in the BLA and elsewhere is mediated by AEA, whereas phasic ECB responses to robust neuronal activation are sub-served by 2-AG [53–56].”
From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [55]
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- Authors
- Ahn, K., McKinney, M. K., & Cravatt, B. F.
- Affiliations
- Scripps Research Institute (US)
- Corresponding author
- Ahn, Kay
- Cravatt, Benjamin F.
- Venue
- Chemical Reviews
- Publisher
- American Chemical Society (ACS)
- Published
- 2008-04-23
- Volume
- 108
- Issue
- 5
- Pages
- 1687-1707
- ISSN
- 0009-2665 (ISSN-L)
- 1520-6890
- PMC
- PMC3150828
- OpenAlex
- W2040634905
- Cited by
- 529
- References
- 187
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 18 · 2023: 16 · 2022: 28 · 2021: 26 · 2020: 32 · 2019: 25 · 2018: 23 · 2017: 27 · 2016: 28 · 2015: 27 · 2014: 43 · 2013: 36 · 2012: 40
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Chemical Reviews (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (DA015197, DA-017259, R01DA015197, P01DA017259)
- Topics
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- endocannabinoid signaling, endocannabinoid biosynthesis, endocannabinoid degradation, fatty acid amide hydrolase, monoacylglycerol lipase, cannabinoid receptors, central nervous system, lipid mediators, enzyme inhibitors
- MeSH terms
- Animals, Arachidonic Acids, Enzymes, Humans, Nervous System, Signal Transduction, Polyunsaturated Alkamides, Cannabinoid Receptor Modulators, Endocannabinoids
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