The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
A meta-analytic review of the impact of intranasal oxytocin administration on cortisol concentrations during laboratory tasks: Moderation by method and mental health
Abstract
Background A large body of research has examined the acute effects of intranasal oxytocin administration on social cognition and stress-regulation. While progress has been made with respect to understanding the effect of oxytocin administration on social cognition in clinical populations (e.g. autism, schizophrenia), less is known about its impact on the functioning of the hypothalamic-pituitary-adrenal (HPA) axis among individuals with a mental disorder.Method We conducted a meta-analysis on the acute effect of intranasal oxytocin administration on the cortisol response to laboratory tasks. The search yielded eighteen studies employing a randomized, placebo-controlled design (k=18, N=675). Random-effects models and moderator analyses were performed using the metafor package for the statistical program R.Results The overall effect size estimate was modest and not statistically significant (Hedges g=-0.151, p=0.11) with moderate heterogeneity in this effect across studies (I(2)=31%). Controlling for baseline differences in cortisol concentrations, moderation analyses revealed that this effect was larger in response to challenging laboratory tasks that produced a robust stimulation of the HPA-axis (Hedges g=-0.433, 95% CI[-0.841, -0.025]), and in clinical populations relative to healthy controls (Hedges g=-0.742, 95% CI[-1.405, -0.078]).Conclusion Overall, oxytocin administration showed greater attenuation of the cortisol response to laboratory tasks that strongly activated the HPA-axis, relative to tasks that did not. The effect was more robust among clinical populations, suggesting possible increased sensitivity to oxytocin among those with a clinical diagnosis and concomitant social difficulties. These data support the view that oxytocin may play an important role in HPA dysfunction associated with psychopathology.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Accumulating evidence from studies in animals and in healthy and psychiatric human populations shows that oxytocin administration may modulate glucocorticoid (16) and autonomic stress reactivity (17), dampen anxiety and neural threat processing (18,19), and beneficially impact socioemotional processes and prosocial behavior (20,21) [but see also (22,23) for seemingly nonprosocial effects].”
From Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients (2017) · cites this paper as [16]
In the citing paper
“Intranasal oxytocin seems to only exert beneficial effects in individuals with suboptimal functioning in domains affected by oxytocin (16,32,65), although a solid neurobiological basis for this hypothesis is still lacking.”
From Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients (2017) · cites this paper as [16]
In the citing paper
“the observation that oxytocin administration had differential effects dependent on acute PTSD symptom severity adds to a growing body of literature indicating that the presence and severity of psychiatric symptoms moderates central and peripheral effects of oxytocin administration (16,64).”
From Intranasal Oxytocin to Prevent Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial in Emergency Department Patients (2017) · cites this paper as [16]
In the citing paper
“For example a recent meta-analysis found that a single dose of intranasal oxytocin lowered cortisol in clinical populations characterised by dysregulation of the HPA axis, but did not significantly influence the cortisol response to stressful stimuli in healthy individuals (Cardoso et al., 2014).”
From Meta-analytic review of the effects of a single dose of intranasal oxytocin on threat processing in humans (2018) · cites this paper as Cardoso et al., 2014
In the citing paper
“Indeed, a previous meta-analysis found that a single dose of oxytocin reduced the cortisol response to stressful stimuli among clinical populations (Cardoso et al., 2014).”
From Meta-analytic review of the effects of a single dose of intranasal oxytocin on threat processing in humans (2018) · cites this paper as Cardoso et al., 2014
Citations
Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048
Conducting Meta-Analyses in R with the metafor Package
Viechtbauer, W. (2010) · Journal of Statistical Software · doi:10.18637/jss.v036.i03 · Cited by 20,464
Wasserman, S. S., Hedges, L. V., & Olkin, I. (1988) · Journal of Educational Statistics · doi:10.2307/1164953 · Cited by 10,361
Dickerson, S. S., & Kemeny, M. E. (2004) · Psychological Bulletin · doi:10.1037/0033-2909.130.3.355 · Cited by 5,881
The Handbook of Research Synthesis and Meta-Analysis
(2019) · doi:10.7758/9781610448864 · Cited by 4,553
Funnel plots for detecting bias in meta-analysis
Sterne, J. A. C., & Egger, M. (2001) · Journal of Clinical Epidemiology · doi:10.1016/s0895-4356(01)00377-8 · Cited by 3,779
Biobehavioral responses to stress in females: Tend-and-befriend, not fight-or-flight.
Taylor, S. E., Klein, L. C., Lewis, B. P., Gruenewald, T. L., Gurung, R. A. R., & Updegraff, J. A. (2000) · Psychological Review · doi:10.1037/0033-295x.107.3.411 · Cited by 3,308
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Cited by
Sorted by citations
Environmental influence in the brain, human welfare and mental health
Tost, H., Champagne, F. A., & Meyer‐Lindenberg, A. (2015) · Nature Neuroscience · doi:10.1038/nn.4108 · Cited by 370
De Dreu, C. K. W., & Kret, M. E. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.020 · Cited by 297
The effects of oxytocin on eating behaviour and metabolism in humans
Lawson, E. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.115 · Cited by 196
Meta-analysis of the effects of intranasal oxytocin on interpretation and expression of emotions
Leppanen, J., Ng, K. W., Tchanturia, K., & Treasure, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.010 · Cited by 188
A Theory of Challenge and Threat States in Athletes: A Revised Conceptualization
Meijen, C., Turner, M. J., Jones, M. V., Sheffield, D., & McCarthy, P. J. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.00126 · Cited by 202
Metadata
- Authors
- Cardoso, C., Kingdon, D., & Ellenbogen, M. A.
- Affiliations
- Concordia University (CA)
- Corresponding author
- Cardoso, Christopher
- ORCID
- Ellenbogen, Mark A.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 49
- Pages
- 161-170
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2068582209
- Semantic Scholar
- 7bbbba514c2d4f16640a1c86c3f9e15a242e28ed
- Cited by
- 171
- References
- 65
- Citations by year
- 2026: 12 · 2025: 14 · 2024: 9 · 2023: 12 · 2022: 16 · 2021: 16 · 2020: 12 · 2019: 19 · 2018: 17 · 2017: 23 · 2016: 12 · 2015: 9
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (CIHR 12678)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- intranasal oxytocin, cortisol, hypothalamic-pituitary-adrenal axis, stress response, mental illness, social cognition, psychopathology
- MeSH terms
- Administration, Intranasal, Adult, Mental Disorders, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Oxytocin, Pituitary-Adrenal System, Psychological Tests, Biomarkers, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
