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Cited by 205Neuroendocrine regulation and behaviorStress Responses and CortisolNeuropeptides and Animal Physiology

Intranasal oxytocin administration attenuates the ACTH stress response in monkeys

Parker, Karen J., Buckmaster, Christine L., Schatzberg, Alan F., Lyons, David M.·2005·Psychoneuroendocrinology
DOI 10.1016/j.psyneuen.2005.04.002
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Abstract

Social relationships protect against the development of stress-related psychiatric disorders, yet little is known about the neurobiology that regulates this phenomenon. Recent evidence suggests that oxytocin (OT), a neuropeptide involved in social bond formation, may play a role. This experiment investigated the effects of chronic intranasal OT administration on acute stress-induced hypothalamic-pituitary-adrenal (HPA) axis activation in adult female squirrel monkeys. Subjects were randomized to one of two experimental conditions. Monkeys were intranasally administered either 50 microg oxytocin (N = 6 monkeys) or 0 microg oxytocin (N = 6 monkeys)/300 microl saline once a day for eight consecutive days. Immediately after drug administration on the eighth day, all monkeys were exposed to acute social isolation. Blood samples for determinations of adrenocorticotropic hormone (ACTH) and cortisol concentrations were collected after 30 and 90 min of stress exposure. Consistent with an anti-stress effect, OT-treated monkeys exhibited lower ACTH concentrations compared to saline-treated monkeys after 90 min of social isolation (F(1,7) = 6.891; P = 0.034). No drug-related differences in cortisol levels were observed, indicating that OT does not directly attenuate the adrenal stress response. Intranasal peptide administration has been shown to penetrate the central nervous system, and research must determine whether intranasally delivered OT exerts its effect(s) at a pituitary and/or brain level. This primate model offers critical opportunities to improve our understanding of the anti-stress effects of OT and may lead to novel pharmacological treatments for stress-related psychiatric disorders.

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  • When administered intranasally, oxytocin attenuates the neuroendocrine stress response in rodents and monkeys and alters emotion regulation in humans.

    “When administered intranasally, OT also attenuates the neuroendocrine stress response in rodents and monkeys and alters emotion regulation in humans (Heinrichs et al., 2003; Parker et al., 2005; Windle et al., 2004).”

    From Effects of intranasal oxytocin on social anxiety in males with fragile X syndrome (2012) · cites this paper as Parker et al., 2005

  • OT has an anti-stress effect in squirrel monkeys, with IN OT treated monkeys exhibiting lower ACTH concentrations compared to saline-treated monkeys 90 minutes following a social isolation stressor.

    “OT has an anti-stress effect in squirrel monkeys, with IN OT treated monkeys exhibiting lower ACTH concentrations compared to saline-treated monkeys 90 minutes following a social isolation stressors (Parker et al., 2005).”

    From Neuropeptide diversity and the regulation of social behavior in New World primates (2016) · cites this paper as Parker et al., 2005

  • OT regulates social stress by acting through the hypothalamic-pituitary-adrenal (HPA) axis.

    “Such OT-mediated reduction in ACTH levels suggests that OT regulates social stress by acting through the hypothalamic-pituitary-adrenal (HPA) axis.”

    From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Parker et al., 2005

  • OT delivered intranasally to squirrel monkeys attenuates stress responses by lowering adrenocorticotropic hormone (ACTH) levels following 90 min of social isolation.

    “Moreover, OT delivered intranasally to squirrel monkeys (Suimiri sciureus) attenuates stress responses by lowering adrenocorticotropic hormone (ACTH) (i.e., corticotropin) levels following 90 min of social isolation (Parker et al., 2005).”

    From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Parker et al., 2005

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Authors
Parker, K. J., Buckmaster, C. L., Schatzberg, A. F., & Lyons, D. M.
Affiliations
Stanford Medicine (US)
Corresponding author
Parker, Karen J.
ORCID
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2005-10
Volume
30
Issue
9
Pages
924-929
ISSN
0306-4530 (ISSN-L)
DOI
10.1016/j.psyneuen.2005.04.002
OpenAlex
W2001711371
Cited by
204
References
34
Citations by year
2026: 2 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 11 · 2021: 19 · 2020: 2 · 2019: 10 · 2018: 16 · 2017: 10 · 2016: 17 · 2015: 20 · 2014: 16 · 2013: 14 · 2012: 6
FWCI
5.35
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (MH-47573, R01MH047573)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords
oxytocin, intranasal administration, ACTH, hypothalamic-pituitary-adrenal axis, acute stress, social isolation, cortisol, anti-stress effects, interpersonal relationships, stress-related psychiatric disorders, squirrel monkey, female primates
MeSH terms
Administration, Intranasal, Adrenocorticotropic Hormone, Animals, Female, Hydrocortisone, Oxytocin, Random Allocation, Saimiri, Social Isolation, Stress, Psychological

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