Cited by 24Stress Responses and CortisolCardiac Health and Mental HealthNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Stress-induced release of matrix metalloproteinase-9 in patients with coronary artery disease: The possible influence of cortisol

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Lundberg, Anna K., Jönsson, Simon, Stenmark, Jonathan, Kristenson, Margareta, Jonasson, Lena·2016·Psychoneuroendocrinology

Abstract

Stress and inflammation are both important risk factors for coronary artery disease (CAD). However, the susceptibility to stress-induced inflammation and its determinants have been little explored in patients with CAD. Here, our aim was to study the stress-induced inflammatory response, more precisely the early release of matrix metalloproteinase (MMP)-9, and its association with cortisol response in patients with CAD. Sixty-four patients underwent a standardized laboratory stress test. The stress-induced release of MMP-9 was closely associated with the release of other neutrophil-associated proteins, MMP-8 and myeloperoxidase (MPO). It also showed a large variation among patients, as did cortisol. Twenty minutes after stress, a negative association between changes in MMP-9 and cortisol was seen (p<0.01). In vitro, dexamethasone reduced the IL-8-mediated release of MMP-9 from neutrophils, indicating that glucocorticoids may exert rapid effects on neutrophil activation. Further characterization of patients revealed that stress-induced release of MMP-9 was related to leukocyte telomere shortening and increased ultrasound-assessed plaque occurrence in the carotid arteries, but not to other characteristics such as age, gender or psychological background factors. The susceptibility to stress-induced release of MMP-9 may thus have impact on disease phenotype. Stress tests can be useful to identify CAD patients in need of novel prevention and treatment strategies.

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Crossref · 10.1016/j.psyneuen.2016.07.219

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Authors
Lundberg, A. K., Jönsson, S., Stenmark, J., Kristenson, M., & Jonasson, L.
Affiliations
Linköping University (SE)
Corresponding author
Jonasson, Lena
Venue
Psychoneuroendocrinology
Publisher
Elsevier BV
Published
2016-11
Volume
73
Pages
117-124
ISSN
0306-4530 (ISSN-L)
OpenAlex
W2492075907
Cited by
24
References
49
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1
FWCI
1.70
Type
journal article
Language
en
Open access
Locations
  • Psychoneuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • KTH Publication Database DiVA (KTH Royal Institute of Technology) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Keywords
coronary artery disease, MMP-9, stress-induced inflammation, cortisol, glucocorticoids, neutrophils, myeloperoxidase, MMP-8, dexamethasone, carotid plaque, stress testing, interleukin-8, disease phenotypes
MeSH terms
Aged, Coronary Artery Disease, Female, Follow-Up Studies, Humans, Hydrocortisone, Inflammation, Male, Middle Aged, Stress, Psychological, Matrix Metalloproteinase 9

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