Cited by 151Tryptophan and brain disordersStress Responses and CortisolVagus Nerve Stimulation Research

Depressive symptoms enhance stress-induced inflammatory responses.

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Fagundes, Christopher P., Glaser, Ronald, Hwang, Beom Seuk, Malarkey, William B., Kiecolt-Glaser, Janice K.·2013·Brain, Behavior, and Immunity

Abstract

Depression is a risk factor for morbidity and mortality, and immune dysregulation may be partially responsible for this link. Proinflammatory cytokines such as interleukin 6 (IL-6) are reliable predictors of quality of life, morbidity, and many causes of mortality. The current study evaluated relationships between depressive symptoms, as assessed by the CES-D, and stress-induced inflammation. The participants, 138 healthy adults, were evaluated at rest, and after a standardized laboratory speech and mental arithmetic stressor. Compared with individuals with fewer depressive symptoms, those with more depressive symptoms produced more IL-6 in response to the stressor, as well as significantly higher levels of IL-6 both 45 min and 2 h after the stressor. These findings add to our emerging understanding of the complex interactions among stress, depression, and immune dysregulation, and provide one potential pathway to explain relationships between depressive symptoms and disease.

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Crossref · 10.1016/j.bbi.2012.05.006

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  • Individuals with diagnosed depression have demonstrated stronger increases in proinflammatory cytokines in response to laboratory stress than non-depressed individuals.

    “Individuals with diagnosed depression have demonstrated stronger increases in proinflammatory cytokines in response to laboratory stress than non-depressed individuals (Weinstein et al., 2010; Fagundes et al., 2013)”

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Authors
Fagundes, C. P., Glaser, R., Hwang, B. S., Malarkey, W. B., & Kiecolt-Glaser, J. K.
Affiliations
  • The Ohio State University Wexner Medical Center (US)
  • The Ohio State University (US)
Venue
Brain, Behavior, and Immunity
Publisher
Elsevier BV
Published
2013-07
Volume
31
Pages
172-176
ISSN
0889-1591 (ISSN-L)
OpenAlex
W2145636091
Cited by
151
References
49
Citations by year
2026: 6 · 2025: 6 · 2024: 3 · 2023: 10 · 2022: 13 · 2021: 12 · 2020: 7 · 2019: 14 · 2018: 14 · 2017: 16 · 2016: 9 · 2015: 8 · 2014: 19 · 2013: 11 · 2012: 2
FWCI
3.94
Type
journal article
Language
en
Open access
Locations
  • Brain Behavior and Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Aging (R01AG029562)
  • National Cancer Institute (CA016058, CA126857, R01CA126857, CA131029, R01CA131029, P30CA016058)
  • National Institute of Dental and Craniofacial Research (DE-014320, T32DE014320)
  • National Center for Research Resources (UL1RR025755)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Neurology › Vagus Nerve Stimulation Research
Keywords
depressive symptoms, stress-induced inflammation, interleukin-6, inflammatory cytokines, immune dysregulation, psychological stress, speech stressor, mental arithmetic stressor, CES-D
MeSH terms
Adult, Depression, Female, Humans, Inflammation, Male, Middle Aged, Stress, Physiological, Stress, Psychological, Interleukin-6

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