Cited by 126Suicide and Self-Harm StudiesStress Responses and CortisolTryptophan and brain disorders

The DOI matches its Crossref record; 74 of the 75 references it cites were found in a registry or an index.

Blunted HPA axis activity prior to suicide attempt and increased inflammation in attempters

Open access

Melhem, Nadine M., Munroe, Sara, Marsland, Anna, Gray, Katarina, Brent, David, Porta, Giovanna, Douaihy, Antoine, Laudenslager, Mark L., DePietro, Frank, Diler, Rasim, Driscoll, Henry, Gopalan, Priya·2017·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2017.01.001PMC PMC5336407

Open this paper in CoChat — free account

Abstract

Background Hypothalamic-Pituitary-Adrenal (HPA) axis dysregulation is associated with increased risk for suicidal behavior. However, it is not clear whether such dysregulation exists prior to or is a consequence of attempt. Studies also show an activation of inflammatory responses in suicidal behavior but often combine attempters with those with ideation. Methods The sample consisted of psychiatric inpatients, aged 15-30 years, admitted for suicide attempt (SA, n=38), inpatients admitted for suicidal ideation with no prior history of attempts (SI, n=40), and healthy controls (n=37). We compared SA, SI, and controls on hair cortisol concentrations (HCC), which provides retrospective levels of cortisol and thus prior to the attempt in SA. We also compared them on the expression of genes in the HPA axis and inflammatory pathways previously implicated in suicidal behavior (GR or NR3C1, SKA2, FKBP5, IL-1β, TNF-α); plasma C-Reactive Protein (CRP); and cellular measures of glucocorticoid receptor (GR) sensitivity and stimulated production of IL-6. Results We found lower HCC [β=-0.55, 95% CI (-0.96, -0.13), p=0.01, ES=-0.54] in first-time SA compared to SI and controls. In addition, SA showed lower GR or NR3C1 (α isoform) mRNA [β=-5.11, 95% CI (-10.9, 0.73), p=0.09, ES=-0.46], higher CRP [β=0.94, 95% CI (-0.004, 1.9), p=0.05, ES=0.60], and higher TNF-α mRNA [β=26.4, 95% CI (7.7, 45.2), p=0.006, ES=0.73]. Conclusions This is the first study to differentiate youth who attempt suicide from those with suicidal ideation on HCC and to show that low HCC precedes suicide attempt. Suicide attempters also showed a distinct biological profile on several markers in both the HPA axis and inflammatory pathways. Future longitudinal studies are needed to examine the ability of these biomarkers to predict suicidal behavior.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.psyneuen.2017.01.001

Cites

74 of 74 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The PHQ-9: Validity of a brief depression severity measure
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2001) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2001.016009606.x · Cited by 44,910
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234
A Global Measure of Perceived Stress
Cohen, S., Kamarck, T., & Mermelstein, R. (1983) · Journal of Health and Social Behavior · doi:10.2307/2136404 · Cited by 32,807
A Brief Measure for Assessing Generalized Anxiety Disorder: The GAD-7
Spitzer, R. L., Kroenke, K., Williams, J. B. W., & Löwe, B. (2006) · Archives of Internal Medicine · doi:10.1001/archinte.166.10.1092 · Cited by 31,765
The social readjustment rating scale
Holmes, T. H., & Rahe, R. H. (1967) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(67)90010-4 · Cited by 11,560
Four Factor Index of Social Status
Paschou, R. (1975) · Cited by 6,989
The measurement of pessimism: the hopelessness scale
Beck, A. T., Weissman, A., Lester, D., & Trexler, L. (1974) · Journal of Consulting and Clinical Psychology · doi:10.1037/h0037562 · Cited by 5,494
The Columbia–Suicide Severity Rating Scale: Initial Validity and Internal Consistency Findings From Three Multisite Studies With Adolescents and Adults
Posner, K., Brown, G. K., Stanley, B., Brent, D. A., Yershova, K. V., Oquendo, M. A., Currier, G. W., Melvin, G. A., Greenhill, L., Shen, S., et al. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.10111704 · Cited by 5,157 · cited 3×
“Suicidal ideation and behavior were assessed during the clinical interview using the Columbia Suicide Severity Rating Scale (C-SSRS) (Posner et al., 2011), which assesses current and lifetime suicidal ideation and attempts, intensity of ideation, and medical lethality of suicide attempts.”
MethodInfluentialSelf-citation
Four Factor Index of Social Status [1975]
Hollingshead, A. B. (1975) · Cited by 5,151
The Aggression Questionnaire.
Buss, A. H., & Perry, M. (1992) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.63.3.452 · Cited by 4,693

Show all 75 references

Sorted by citations

Annual Research Review: Suicide among youth – epidemiology, (potential) etiology, and treatment
Cha, C. B., Franz, P. J., M. Guzmán, E., Glenn, C. R., Kleiman, E. M., & Nock, M. K. (2018) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12831 · Cited by 602
Severity and Variability of Depression Symptoms Predicting Suicide Attempt in High-Risk Individuals
Melhem, N., Porta, G., Oquendo, M. A., Zelazny, J. M., Keilp, J. G., Iyengar, S., Burke, A. K., Birmaher, B. B., Stanley, B., Mann, J. J., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.4513 · Cited by 261
Self-citation
Adolescent Suicide as a Failure of Acute Stress-Response Systems.
Miller, A. B., & Prinstein, M. J. (2019) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-050718-095625 · Cited by 235
“…studies with combined samples of adults and youths, individuals with a lifetime history of suicidal behavior have had lower baseline levels or hair concentrations of cortisol compared with individuals with only suicidal ideation or with healthy controls (Keilp et al. 2016, Melhem et al. 2017).”
Background
A specific inflammatory profile underlying suicide risk? Systematic review of the main literature findings
Serafini, G., Parisi, V. M., Aguglia, A., Amerio, A., Sampogna, G., Fiorillo, A., Pompili, M., & Amore, M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17072393 · Cited by 172
The Involvement of Hypothalamus–Pituitary–Adrenal (HPA) Axis in Suicide Risk
Berardelli, I., Serafini, G., Cortese, N., Fiaschè, F., O’Connor, R. C., & Pompili, M. (2020) · Brain Sciences · doi:10.3390/brainsci10090653 · Cited by 184
The association between adversity and hair cortisol levels in humans: A meta-analysis
Khoury, J. E., Bosquet Enlow, M., Plamondon, A., & Lyons-Ruth, K. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.01.009 · Cited by 170
Toward fine-grained phenotyping of suicidal behavior: the role of suicidal subtypes
Bernanke, J. A., Stanley, B. H., & Oquendo, M. A. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.123 · Cited by 122
Sleep problems and suicidal behaviors in college students
Becker, S. P., Dvorsky, M. R., Holdaway, A. S., & Luebbe, A. M. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.01.009 · Cited by 116
Inflammation and nitro-oxidative stress in current suicidal attempts and current suicidal ideation: a systematic review and meta-analysis
Vasupanrajit, A., Jirakran, K., Tunvirachaisakul, C., Solmi, M., & Maes, M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01407-4 · Cited by 109
Hair cortisol concentrations in mental disorders: A systematic review
Koumantarou Malisiova, E., Mourikis, I., Darviri, C., Nicolaides, N. C., Zervas, I. M., Papageorgiou, C., & Chrousos, G. P. (2021) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113244 · Cited by 99
Effects of childhood trauma on cortisol levels in suicide attempters and ideators
O'Connor, D. B., Green, J. A., Ferguson, E., O’Carroll, R. E., & O’Connor, R. C. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.11.004 · Cited by 98
Biological bases of suicidal behaviours: a narrative review
Lengvenyte, A., Conejero, I., Courtet, P., & Olié, E. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.14635 · Cited by 87
Child maltreatment and hypothalamic-pituitary-adrenal axis functioning: A systematic review and meta-analysis
Schär, S., Mürner-Lavanchy, I., Schmidt, S. J., Koenig, J., & Kaess, M. (2022) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2022.100987 · Cited by 71
Suicide attempts are associated with activated immune-inflammatory, nitro-oxidative, and neurotoxic pathways: A systematic review and meta-analysis
Vasupanrajit, A., Jirakran, K., Tunvirachaisakul, C., & Maes, M. H. J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.08.015 · Cited by 69
Immune-related biomarkers and suicidal behaviors: A meta-analysis
Neupane, S. P., Daray, F. M., Ballard, E. D., Galfalvy, H., Itzhaky, L., Segev, A., Shelef, A., Tene, O., Rizk, M., Mann, J. J., et al. (2023) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2023.05.009 · Cited by 76
Candidate Biomarkers of Suicide Crisis Syndrome: What to Test Next? A Concept Paper
Calati, R., Nemeroff, C. B., López‐Castromán, J., Cohen, L. J., & GALYNKER, I. I. (2019) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyz063 · Cited by 65
Neurobiology of COVID-19: how can the virus affect the brain?
Generoso, J. S., de Quevedo, J. L. B., Cattani, M., Lodetti, B. F., Sousa, L., Collodel, A., Díaz, A. P., & Dal‐Pizzol, F. (2021) · Brazilian Journal of Psychiatry · doi:10.1590/1516-4446-2020-1488 · Cited by 65
Effects of childhood trauma, daily stress, and emotions on daily cortisol levels in individuals vulnerable to suicide.
O'Connor, D. B., Branley-Bell, D., Green, J. A., Ferguson, E., O'Carroll, R. E., & O'Connor, R. C. (2020) · Journal of Abnormal Psychology · doi:10.1037/abn0000482 · Cited by 60
Cluster Headache Clinical Phenotypes: Tobacco Nonexposed (Never Smoker and No Parental Secondary Smoke Exposure as a Child) versus Tobacco‐Exposed: Results from the United States Cluster Headache Survey
Rozen, T. D. (2018) · Headache The Journal of Head and Face Pain · doi:10.1111/head.13295 · Cited by 56
Aggression, impulsivity and inflammatory markers as risk factors for suicidal behavior
Coryell, W. H., Wilcox, H. C., Evans, S. J., Pandey, G. N., Jones‐Brando, L. V., Dickerson, F., & Yolken, R. H. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.09.004 · Cited by 58
Associations of three major physiological stress systems with suicidal ideation and suicide attempts in patients with a depressive and/or anxiety disorder
Wiebenga, J. X. M., Heering, H. D., Eikelenboom, M., van Hemert, A. M., van Oppen, P., & Penninx, B. W. J. H. (2022) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2022.02.021 · Cited by 53
Suicide Biomarkers to Predict Risk, Classify Diagnostic Subtypes, and Identify Novel Therapeutic Targets: 5 Years of Promising Research
Johnston, J. N., Campbell, D., Caruncho, H. J., Henter, I. D., Ballard, E. D., & Zarate, C. A. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab083 · Cited by 59
Sleep fragmentation engages stress-responsive circuitry, enhances inflammation and compromises hippocampal function following traumatic brain injury
Tapp, Z. M., Cornelius, S., Oberster, A., Kumar, J. E., Atluri, R. R., Witcher, K. G., Oliver, B., Bray, C. E., Velasquez, J., Zhao, F., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114058 · Cited by 49
The role of substance use, smoking, and inflammation in risk for suicidal behavior
Chang, H. B., Munroe, S., Gray, K., Porta, G., Douaihy, A. B., Marsland, A. L., Brent, D. A., & Melhem, N. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.09.005 · Cited by 50
Self-citation
Role of resilience and social support in the relationship between loneliness and suicidal ideation among Chinese nursing home residents
Zhang, D., Wang, R., Zhao, X., Zhang, J., Jia, J., Su, Y., & Wang, K. (2020) · Aging & Mental Health · doi:10.1080/13607863.2020.1786798 · Cited by 46
The Role of Inflammation in the Pathophysiology of Depression and Suicidal Behavior
Serafini, G., Costanza, A., Aguglia, A., Amerio, A., Trabucco, A., Escelsior, A., Sher, L., & Amore, M. (2022) · Medical Clinics of North America · doi:10.1016/j.mcna.2022.09.001 · Cited by 48
Suicide, neuroinflammation and other physiological alterations
Bengoechea-Fortes, S. D. L. P., Ramı́rez-Expósito, M. J., & Martı́nez-Martos, J. M. (2023) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-023-01584-z · Cited by 39
Psilocybin, a Naturally Occurring Indoleamine Compound, Could Be Useful to Prevent Suicidal Behaviors
Strumila, R., Nobile, B., Korsakova, L., Lengvenytė, A., Olié, É., López‐Castromán, J., Guillaume, S., & Courtet, P. (2021) · Pharmaceuticals · doi:10.3390/ph14121213 · Cited by 40
Cortisol response to stress as a predictor for suicidal ideation in youth
Shalev, A., Porta, G., Biernesser, C. L., Zelazny, J. M., Payne, M. W., Melhem, N., & Brent, D. A. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.06.053 · Cited by 36
Self-citation
Effects of chronic physical disease and systemic inflammation on suicide risk in patients with depression: a hospital-based case–control study
Oh, K. Y., Dam, N. T. V., Doucette, J. T., & Murrough, J. W. (2019) · Psychological Medicine · doi:10.1017/s0033291718003902 · Cited by 34
Predictive inflammatory biomarkers for change in suicidal ideation in major depressive disorder and panic disorder: A 12-week follow-up study
Choi, K. W., Jang, E. H., Kim, A. Y., Kim, H., Park, M. J., Byun, S., D, M. F. M., Mischoulon, D., Papakostas, G. I., Yu, H. Y., et al. (2020) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2020.12.011 · Cited by 35
Associations among inflammation, mental health, and quality of life in adults with metabolic syndrome
Kim, J.-R., Kim, H.-N., & Song, S.-W. (2018) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-018-0367-9 · Cited by 33
SKA2/FAM33A: A novel gene implicated in cell cycle, tumorigenesis, and psychiatric disorders
Xie, M., & Bu, Y. (2018) · Genes & Diseases · doi:10.1016/j.gendis.2018.11.001 · Cited by 33
Adolescent nonsuicidal self-injury and cortisol response to the retrieval of adversity: A sibling study
Reichl, C., Brunner, R. M., Bender, N., Parzer, P., Koenig, J., Resch, F., & Kaess, M. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104460 · Cited by 31
Abnormal stress responsiveness and suicidal behavior: a risk phenotype
Steinberg, L. J., & Mann, J. J. (2020) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2020.100011 · Cited by 29
Changes In Plasma NPY, IL-1β And Hypocretin In People Who Died By Suicide
Lü, J., Li, S., Li, H., Mou, T., Zhou, L., Huang, B., Huang, M., & Xu, Y. (2019) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s219962 · Cited by 25
The role of childhood maltreatment in cortisol in the hypothalamic–pituitary–adrenal (HPA) axis in methamphetamine-dependent individuals with and without depression comorbidity and suicide attempts
Pirnia, B., Khosravani, V., Maleki, F., Kalbasi, R., Pirnia, K., Malekanmehr, P., & Zahiroddin, A. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.11.168 · Cited by 25
Effects of weariness of life, suicide ideations and suicide attempt on HPA axis regulation in depression
Hennings, J. M., Ising, M., Uhr, M., Holsboer, F., & Lucae, S. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105286 · Cited by 25
Suicide and suicide behaviors: A review of transcriptomics and multiomics studies in psychiatric disorders
Zhou, Y., Lutz, P.-É., Ibrahim, E. C., Courtet, P., Tzavara, E. T., Turecki, G., & Belzeaux-R, R. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24367 · Cited by 29
Associations of potential plasma biomarkers with suicide attempt history, current suicidal ideation and subsequent suicidal events in patients with depression: A discovery study
Lengvenytė, A., Belzeaux-R, R., Olié, É., Hamzeh‐Cognasse, H., Sénèque, M., Strumila, R., Cognasse, F., & Courtet, P. (2023) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2023.08.025 · Cited by 25
A network meta-analysis of stress mediators in suicide behaviour
Thomas, N., Armstrong, C. W., Hudaib, A., Kulkarni, J., & Gurvich, C. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100946 · Cited by 27
Effectiveness of a resilience-targeted intervention based on “I have, I am, I can” strategy on nursing home older adults' suicidal ideation: A randomized controlled trial
Zhang, D., Tian, Y., Wang, R., Wang, L., Wang, P., & Su, Y. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.04.046 · Cited by 23
DNA Methylation of Genes Involved in the HPA Axis in Presence of Suicide Behavior: A Systematic Review
Dionisio-García, D. M., Mendoza, A. D. G., González‐Castro, T. B., Tovilla‐Zárate, C. A., Juárez‐Rojop, I. E., López‐Narváez, M. L., Hernández‐Díaz, Y., Nicolini, H., & Olvera‐Hernández, V. (2023) · Brain Sciences · doi:10.3390/brainsci13040584 · Cited by 25
Graves’ disease as a driver of depression: a mechanistic insight
Song, Y., Wang, X., Ma, W., Yang, Y., Yan, S., Sun, J., Zhu, X., & Tang, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1162445 · Cited by 26
Brain and blood transcriptome profiles delineate common genetic pathways across suicidal ideation and suicide
Sun, S., Liu, Q., Wang, Z., Huang, Y.-Y., Sublette, M. E., Dwork, A. J., Rosoklija, G. B., Ge, Y., Galfalvy, H., Mann, J. J., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02420-z · Cited by 24
Signaling networks in inflammatory pathways and risk for suicidal behavior
Rengasamy, M., Zhong, Y., Marsland, A., Chen, K., Douaihy, A., Brent, D., & Melhem, N. M. (2020) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2020.100122 · Cited by 21
Self-citation
Associations of serum cortisol levels, stress perception, and stressful events with suicidal behaviors in patients with depressive disorders
Choi, W., Kang, H., Kim, J., Kim, H. K., Kang, H., Lee, J., Kim, S., Stewart, R. J., & Kim, J. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.10.054 · Cited by 23
Implementing Evidence-Based Suicide Prevention Strategies for Greatest Impact
Melhem, N., Moutier, C. Y., & Brent, D. A. (2023) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20220078 · Cited by 23
Self-citation
Brain 5-HT1A Receptor PET Binding, Cortisol Responses to Stress, and the Familial Transmission of Suicidal Behavior
Melhem, N., Zhong, Y., Miller, J. M., Zanderigo, F., Ogden, R. T., Sublette, M. E., Newell, M., Burke, A. K., Keilp, J. G., Lesanpezeshki, M., et al. (2021) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyab060 · Cited by 20
Self-citation
Proinflammatory cytokine levels, cognitive function, and suicidal symptoms of adolescents and young adults with major depressive disorder
Chen, M., Bai, Y., Hsu, J.-W., Huang, K., & Tsai, S. (2024) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-024-01780-5 · Cited by 18
The Potential Mechanisms of High-Velocity, Low-Amplitude, Controlled Vertebral Thrusts on Neuroimmune Function: A Narrative Review
Haavik, H., Niazi, I. K., Kumari, N., Amjad, I., Duehr, J., & Holt, K. R. (2021) · Medicina · doi:10.3390/medicina57060536 · Cited by 19
Suicide and Inflammation
Donegan, J. J., & Nemeroff, C. B. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-981-19-7376-5_17 · Cited by 19
Symptom trajectories in the months before and after a suicide attempt in individuals with bipolar disorder: A STEP‐BD study
Ballard, E. D., Farmer, C., Shovestul, B. J., Voort, J. V., Machado‐Vieira, R., Park, L., Merikangas, K. R., & Zarate, C. A. (2019) · Bipolar Disorders · doi:10.1111/bdi.12873 · Cited by 17
Association of insomnia phenotypes based on polysomnography-measured sleep duration with suicidal ideation and attempts
Saulnier, K. G., Singh, R., Lenker, K. P., Calhoun, S. L., He, F., Liao, D., Vgontzas, A. N., Bixler, E. O., & Fernández‐Mendoza, J. (2022) · Sleep Health · doi:10.1016/j.sleh.2022.05.004 · Cited by 17
Gene-environment interaction between HPA-axis genes and trauma exposure in the suicide behavior: A systematic review
González‐Castro, T. B., Juárez‐Rojop, I. E., Tovilla‐Zárate, C. A., Ovando-Ricárdez, J. A., Hernández‐Díaz, Y., López‐Narváez, M. L., Mendoza, A. D. G., & Rodríguez-Pérez, C. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.06.011 · Cited by 18
Association and Genetic Expression between Genes Involved in HPA Axis and Suicide Behavior: A Systematic Review
Hernández‐Díaz, Y., Mendoza, A. D. G., González‐Castro, T. B., Tovilla‐Zárate, C. A., Juárez‐Rojop, I. E., López‐Narváez, M. L., & Nicolini, H. (2021) · Genes · doi:10.3390/genes12101608 · Cited by 19
New frontiers in suicide vulnerability: immune system and sex hormones
Lombardo, G. (2021) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2021.100384 · Cited by 15
Higher levels of plasma Adrenocorticotropic hormone (ACTH) are associated with lower suicidal ideation in depressed patients compared to controls and suicide attempters, independently from depression severity
Strumila, R., Lengvenytė, A., Zdanavičius, L., Badaras, R., Dlugauskas, E., Lesinskienė, S., Matiekus, E., Marcinkevicius, M., Vencevičienė, L., Utkus, A., et al. (2024) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2024.100235 · Cited by 16
Exploring risk and protective factors which distinguish suicidal and self-harm behaviours from suicidal and self-harm ideation in young people: A systematic review
Etherson, M. E., Lee, S., Loney, K. J., Steward, I. P., Ward, J., McClelland, H., Kandola, A. A., Mendes, J. A. D. A., Hollis, C. P., Townsend, E., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0326381 · Cited by 15
Association of markers of inflammation and intestinal permeability in suicidal patients with major mood disorders
Brouillet, J. Z., Boltri, M., Lengvenytė, A., Lajnef, M., Richard, J., Barrau, C., Strumila, R., Coyac, M., Wu, C., Boukouaci, W., et al. (2023) · Journal of Affective Disorders Reports · doi:10.1016/j.jadr.2023.100624 · Cited by 15
Impulsivity across severe mental disorders: a cross-sectional study of immune markers and psychopharmacotherapy
Hjell, G., Rokicki, J., Szabó, A., Holst, R., Tesli, N., Bell, C., Fischer-Vieler, T., Werner, M. C. F., Lunding, S. H., Ormerod, M. B. E. G., et al. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-05154-4 · Cited by 14
Interest of neuroimaging of social exclusion in suicide
Olié, É., & Courtet, P. (2018) · Journal of Neuroscience Research · doi:10.1002/jnr.24314 · Cited by 16
Recurrent suicide attempts affect normalization of HPA axis dysregulation after recovery from major depression
Hennings, J. M., Ising, M., Uhr, M., Holsboer, F., & Lucae, S. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.937582 · Cited by 13
Network analysis of comorbid depression, suicidality and biomarkers on HPA axis among mood disorder patients to psychiatric emergency services
Wang, Y., You, G.-Y., Han, T., Liu, Y., Li, J., Xiao, J., & Xie, X.-M. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02503-5 · Cited by 14
Increased burden of cardiovascular risk among youth suicide attempters
Zhong, Y., Pham, S., Porta, G., Douaihy, A. B., Marsland, A. L., Brent, D. A., & Melhem, N. (2020) · Psychological Medicine · doi:10.1017/s0033291720003736 · Cited by 13
Self-citation
Relationship between serum inflammatory cytokines and suicide risk in patients with major depressive disorder
Yang, Y., Gu, K., & Li, J. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1422511 · Cited by 13
Increased cell number with reduced nitric oxide level and augmented superoxide dismutase activity in the anterior-pituitary region of young suicide completers
Baltazar‐Gaytán, E., Aguilar‐Alonso, P., Brambila, E., Tendilla‐Beltrán, H., Vázquez‐Roque, R. A., Morales‐Medina, J. C., Maceda-Mártinez, N., Castro-Flores, C., Susano-Pompeyo, M., Garcés‐Ramírez, L., et al. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.11.002 · Cited by 12
Biological Responses to Acute Stress and Suicide: a Review and Opportunities for Methodological Innovation
Miller, A. B., & Eisenlohr-Moul, T. A. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-00185-2 · Cited by 12
IL-6 predicts non-suicidal self-injury over 3 months in high-risk adolescents
Bai, S., Asarnow, J. R., Babeva, K. N., & Irwin, M. R. (2024) · BJPsych Open · doi:10.1192/bjo.2023.656 · Cited by 10
Peripheral Markers of Suicidal Behavior: Current Findings and Clinical Implications
Kang, H., Kim, J., Kim, S., Han, J., Lyoo, I. K., & Kim, J. (2023) · Clinical Psychopharmacology and Neuroscience · doi:10.9758/cpn.22.1046 · Cited by 10
The role of gene polymorphisms, and analysis of peripheral and central levels of interleukins in suicidal behavior: A systematic review
González‐Castro, T. B., Tovilla‐Zárate, C. A., Juárez‐Rojop, I. E., López‐Narváez, M. L., Pérez‐Hernández, N., Rodrı́guez-Pérez, J. M., & Mendoza, A. D. G. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.10.024 · Cited by 12
NR3C1 and NR3C2 Genes Increase the Risk of Suicide Attempt in Psychiatric Disorder Patients with History of Childhood Trauma
Sanabrais‐Jiménez, M. A., Esquivel-López, A., Sotelo-Ramírez, C. E., Aguilar-García, A., Ordoñez-Martínez, B., Pavón, J. J., Madrigal-Lara, M., Díaz-Vivanco, A., & Camarena, B. (2023) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s431176 · Cited by 12
Coping style and cortisol levels in infancy predict hair cortisol following new group formation in captive rhesus macaques (Macaca mulatta)
Linden, J. B., Capitanio, J., McCowan, B., & Isbell, L. (2018) · American Journal of Primatology · doi:10.1002/ajp.22938 · Cited by 8
Effects on Behavior by Different Exposure Durations of Predator Scent Stress
Migliaro, M. (2020) · Acta de Investigación Psicológica · doi:10.22201/fpsi.20074719e.2020.2.343 · Cited by 9
The Role of Epigenetic Dysregulation in Suicidal Behaviors
Fiori, L. M., & Turecki, G. (2020) · Current topics in behavioral neurosciences · doi:10.1007/7854_2020_160 · Cited by 10
Etiopathogenesis of Suicide: A Conceptual Analysis of Risk and Prevention Within a Comprehensive, Deterministic Model
Lennon, J. C. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02087 · Cited by 10
Effects of stress on endophenotypes of suicide across species: A role for ketamine in risk mitigation
Lamontagne, S. J., Ballard, E. D., & Zarate, C. A. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100450 · Cited by 10
A Networked Model of Ecological Systems Theory to Discuss Concerns in Italian Bisexual+ and Transgender People After the Block of the “Zan Bill” by Senate
Rucco, D., Toffoli, G., Anzani, A., & Prunas, A. (2023) · Sexuality Research and Social Policy · doi:10.1007/s13178-023-00906-z · Cited by 8
Inflammation and Nitro-Oxidative Stress in Current Suicidal Attempts and Current Suicidal Ideation: a Systematic Review and Meta-AnalysisPreprint
Vasupanrajit, A., Jirakran, K., Tunvirachaisakul, C., Solmi, M., & Maes, M. H. J. (2021) · Preprints.org · doi:10.20944/preprints202109.0159.v1 · Cited by 8
Inflammatory pathology in depression and suicide: a mechanistic distillation of clinical correlates
Costanza, A., Amerio, A., Aguglia, A., Magnani, L., Parise, A., Nguyen, K. D., Berardelli, I., Pompili, M., Amore, M., & Serafini, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1479471 · Cited by 7
Testing the role of inflammation in the relation of childhood maltreatment and suicidal ideation among young adults
Walker, J. H., Venta, A. C., Bechelli, J., Brewer, T. M., Boisvert, D. L., Bick, J. R., Lewis, R. H., Wells, J., & Armstrong, T. A. (2022) · Journal of Clinical Psychology · doi:10.1002/jclp.23347 · Cited by 8
Alcohol Consumption and Suicidal Behavior: Current Research Evidence and Potential for Prevention
Kõlves, K., Crossin, R., & Witt, K. (2022) · Springer eBooks · doi:10.1007/978-3-030-67928-6_61-1 · Cited by 9
Childhood trauma cortisol and immune cell glucocorticoid transcript levels are associated with increased risk for suicidality in adolescence
Goltser‐Dubner, T., Benarroch, F., Lavon, M., Amer, R., Canetti, L., Giesser, R., Kianski, E., Martin, J., Pevzner, D., Weinberg, P. B., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-02923-3 · Cited by 6
Early life stress unravels epistatic genetic associations of cortisol pathway genes with depression
Pereira, S. C., Coeli‐Lacchini, F. B., Pereira, D. A., Ferezin, L. P., Menezes, I. C., Baes, C. V. W., Luizon, M. R., Juruena, M. F., Cleare, A. J., Young, A. H., et al. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.05.032 · Cited by 7
Commentary: Sex Differences in the Peripheral Immune System in Patients with Depression
Breidenstein, J., Przyborowski, C., & Walther, A. (2017) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2017.00145 · Cited by 6
The rs7208505 Polymorphism and Differential Expression of the SKA 2 Gene in the Prefrontal Cortex of Suicide Victims from the Mexican Population
Valenzuela‐García, L. I., Ayala‐García, V. M., Ramos-Rosales, D. F., Jacquez-Flores, R. E., Úrtiz-Estrada, N., Hernández, E., & Barraza-Salas, M. (2023) · Archives of Suicide Research · doi:10.1080/13811118.2023.2209155 · Cited by 6
Investigating Predictive Factors of Suicidal Re-attempts in Adolescents and Young Adults After a First Suicide Attempt, a Prospective Cohort Study. Study Protocol of the SURAYA Project
Abrial, E., Chalancon, B., Leaune, É., Brunelin, J., Wallon, M., Moll, F., Barakat, N., Hoestlandt, B., Fourier, A., Simon, L., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.916640 · Cited by 6
Chronische Suizidalität – eine besondere Form der Suizidalität?
Hennings, J. M. (2022) · Nervenheilkunde · doi:10.1055/a-1758-8212 · Cited by 4
Early Childhood Adversity, Stress, and Developmental Pathways of Suicide Risk
Ortin‐Peralta, A., Myruski, S., Rosario‐Williams, B., & Xu, M. (2021) · Springer eBooks · doi:10.1007/978-3-030-82465-5_3 · Cited by 5
Differential expression of HTR2A and MAOA genes in the prefrontal cortex and hypothalamus of suicide victims from Mexican population
Ramos-Rosales, D. F., Méndez-Hernández, E. M., Salas-Pacheco, J. M., Salas-Leal, A. C., Úrtiz-Estrada, N., Barraza-Salas, M., & Peña, P. P. (2022) · Neuroscience Letters · doi:10.1016/j.neulet.2022.136611 · Cited by 3
Peripheral biological correlates of suicidality in children and adolescents: A systematic review and meta-analysis
Pak, T. K., Ayvaci, E. R., Carmody, T. J., Jamma, L., Feng, Z., Nekovei, A., Emslie, G. J., & Trivedi, M. H. (2025) · iScience · doi:10.1016/j.isci.2025.112290 · Cited by 4
Epigenetics and immunology: Under-recognized aspects of suicidality
Kouter, K., Šmon, J., & Paska, A. V. (2025) · World Journal of Psychiatry · doi:10.5498/wjp.v15.i9.107726 · Cited by 3
Exploring the link between adolescent inhalant misuse and suicidal behaviour: a behavioural toxicology perspective
Crossin, R. (2021) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2021.107038 · Cited by 3
Assessing suicide risk in chronic pain management: a narrative review across drug classes
Brezić, N., Gligorevic, S., Candido, K. D., & Knežević, N. N. (2024) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2024.2391999 · Cited by 2
Do Cortisol Levels Play a Role in Suicidal Behaviors and Non-Suicidal Self-Injuries in Children and Adolescents?—A Narrative Review
Sporniak, B., & Szewczuk-Bogusławska, M. (2025) · Brain Sciences · doi:10.3390/brainsci15030287 · Cited by 3
Stress Response in Suicide Attempters with Borderline Personality Disorder: The Role of Behavioral Problems in Childhood
Itzhaky, L., Galfalvy, H., Keilp, J. G., Gratch, I., Brodsky, B. S., & Stanley, B. (2020) · Psychiatry · doi:10.1080/00332747.2020.1716439 · Cited by 2
Influences of sleep, cortisol reactivity, and risk/reward-based decision-making on suicide
Law, K. C., O’Connell, K. L., Jacobson, S. V., Baer, M. M., Baker, P. M., & Tull, M. T. (2024) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2024.101975 · Cited by 2
Depression severity and verbal comprehension in children and adolescents with a major depressive episode
Trasolini, M., Serra, G., Iannoni, M. E., Andracchio, E., Apicella, M., Maglio, G., Menghini, D., & Vicari, S. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1395391 · Cited by 2
Predicting Suicidal Ideation and Attempts Using Biomarkers: Hope for Death Prevention in a Depressed Society
Emokpae, M. A., Osifo, J. O., Emokpae, L. A., ERHUNMWUNSE, R. U., & Ayomide, I. B. (2024) · Journal of Behavioral and Brain Science · doi:10.4236/jbbs.2024.1412020 · Cited by 2
Hair Collection for Cortisol Among Youth Experiencing Homelessness
Ford, J. L., Slesnick, N., Kelleher, K. J., Brakenhoff, B. R., Chavez, L. J., Feng, X., Mallory, A. B., Moore, L., O’Connor, R., Pinkus, L., et al. (2023) · Nursing Research · doi:10.1097/nnr.0000000000000664 · Cited by 2

Authors: Melhem, N. M., Munroe, S., Marsland, A., Gray, K., Brent, D., Porta, G., Douaihy, A., Laudenslager, M. L., DePietro, F., Diler, R., Driscoll, H., & Gopalan, P.
Affiliations: University of Pittsburgh (US)
University of Pittsburgh Medical Center (US)
University of Colorado Anschutz (US)
Corresponding author: Melhem, Nadine M.
ORCID: Melhem, Nadine M.
Marsland, Anna
Brent, David
Laudenslager, Mark L.
Diler, Rasim
Gopalan, Priya
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2017-03
Volume: 77
Pages: 284-294
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2017.01.001
PMC: PMC5336407
OpenAlex: W2570996757
Cited by: 124
References: 75
Citations by year: 2026: 8 · 2025: 12 · 2024: 11 · 2023: 18 · 2022: 16 · 2021: 15 · 2020: 16 · 2019: 14 · 2018: 10 · 2017: 4
FWCI: 14.08
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R21MH101208)
Topics: Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: suicide attempts, suicidal ideation, HPA axis dysregulation, hair cortisol, glucocorticoid receptor, inflammation, C-reactive protein, TNF-α, interleukin-6, FKBP5, SKA2, youth
MeSH terms: Adolescent, Adult, C-Reactive Protein, Female, Hair, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Inflammation, Inpatients, Male, Pituitary-Adrenal System, Retrospective Studies, Suicide, Attempted, Biomarkers, Interleukin-6, Young Adult, Suicidal Ideation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Blunted HPA axis activity prior to suicide attempt and increased inflammation in attempters

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks