Toward fine-grained phenotyping of suicidal behavior: the role of suicidal subtypes
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Despite advances in the assessment and management of suicidal behavior (SB), suicide remains a leading cause of morbidity and mortality in the United States, and suicide rates have increased dramatically over the past 30 years. 1 There is ample evidence that suicidal thoughts and behaviors are transdiagnostic phenomena that can arise even in the absence of other diagnosable mental health disorders. 2 While attempts to elucidate a unified model of SB have identified genetic, neurobiological, and psychological factors that are associated with increased risk, these risk factors, or their combination, have only modest statistical and limited clinical utility. 3 Thus, predicting who will engage in SB remains challenging. We assert that, rather than being a unified construct, SB likely represents a final common pathway of multiple separate pathological processes. Here, we hypothesize that the pattern of suicidal thinking helps distinguish at least two of these suicidal subtypes.
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A stress-related subtype of suicidality may be expected to demonstrate blunted CORT responses, while other subtypes may have different characteristics.
“While a stress-related subtype of suicidality (characterized broadly by episodes of suicidality following stress, trauma histories, and impulsivity [49]) may be expected to demonstrate blunted CORT responses, other subtypes may have different characteristics.”
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Enriching the Assessment of Suicidal Ideation
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- Authors
- Bernanke, J. A., Stanley, B. H., & Oquendo, M. A.
- Affiliations
- New York State Psychiatric Institute (US)
- Columbia University (US)
- University of Pennsylvania (US)
- Corresponding author
- Oquendo, M A
- Venue
- Molecular Psychiatry
- Published
- 2017-06-13
- Volume
- 22
- Issue
- 8
- Pages
- 1080-1081
- ISSN
- 1359-4184 (ISSN-L)
- 1476-5578
- PMC
- PMC5785781
- OpenAlex
- W2625168316
- Cited by
- 122
- References
- 23
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 20 · 2023: 10 · 2022: 12 · 2021: 18 · 2020: 12 · 2019: 13 · 2018: 5 · 2017: 2
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Molecular Psychiatry (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by-nc-sa)
- Funders
- National Institute of Mental Health (P50MH090964, R01MH109326, MH090964, R01MH061017)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Social Sciences › Sociology and Political Science › Homicide, Infanticide, and Child Abuse
- Social Sciences › Psychology › Social Psychology › Mental Health via Writing
- Keywords
- suicidal behavior, suicide risk prediction, suicidal ideation, transdiagnostic mechanisms, suicide prevention, suicide risk factors
- MeSH terms
- Humans, Suicide, Suicide, Attempted, Suicidal Ideation
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