Cited by 177Maternal Mental Health During Pregnancy and PostpartumPregnancy-related medical researchStress Responses and Cortisol

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Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study

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Osborne, Lauren M., Gispen, Fiona, Sanyal, Abanti, Yenokyan, Gayane, Meilman, Samantha, Payne, Jennifer L.·2017·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2017.02.012PMC PMC5420429

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Abstract

Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant women with a prior diagnosis of a mood disorder. Methods included multivariate and logistic regression with general linear mixed effect models. We found that, after adjustment, every additional ng/mL of T2 ALLO resulted in a 63% (95% CI 13% to 84%, p=0.022) reduction in the risk of developing PPD. Our findings extend previous work connecting ALLO and depression within pregnancy, and indicate that the relationship between pregnancy ALLO and PPD is worth further exploration in a larger sample.

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Authors: Osborne, L. M., Gispen, F., Sanyal, A., Yenokyan, G., Meilman, S., & Payne, J. L.
Affiliations: Johns Hopkins University (US)
Corresponding author: Osborne, Lauren M.
ORCID: Osborne, Lauren M.
Gispen, Fiona
Sanyal, Abanti
Yenokyan, Gayane
Payne, Jennifer L.
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2017-05
Volume: 79
Pages: 116-121
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2017.02.012
PMC: PMC5420429
OpenAlex: W2588649755
Cited by: 175
References: 55
Citations by year: 2026: 14 · 2025: 16 · 2024: 24 · 2023: 17 · 2022: 21 · 2021: 26 · 2020: 20 · 2019: 26 · 2018: 10 · 2017: 1
FWCI: 14.64
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01MH104262, K23MH074799, R01MH112704)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy-related medical research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: allopregnanolone, progesterone, postpartum depression, pregnancy, perinatal mood disorders, progesterone metabolites, second trimester, third trimester, risk prediction
MeSH terms: Adolescent, Adult, Female, Humans, Middle Aged, Predictive Value of Tests, Pregnancy, Pregnancy Trimester, Third, Pregnanolone, Progesterone, Depression, Postpartum, Young Adult

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Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study

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