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Lower allopregnanolone during pregnancy predicts postpartum depression: An exploratory study
Open accessAbstract
Current evidence is mixed on the role of progesterone and its metabolites in perinatal mood and anxiety disorders. We measured second and third trimester (T2 and T3) progesterone (PROG) and allopregnanolone (ALLO) levels by ELISA and postpartum depression (PPD) by clinician interview (DSM-IV criteria) in 60 pregnant women with a prior diagnosis of a mood disorder. Methods included multivariate and logistic regression with general linear mixed effect models. We found that, after adjustment, every additional ng/mL of T2 ALLO resulted in a 63% (95% CI 13% to 84%, p=0.022) reduction in the risk of developing PPD. Our findings extend previous work connecting ALLO and depression within pregnancy, and indicate that the relationship between pregnancy ALLO and PPD is worth further exploration in a larger sample.
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“One potential factor affecting GABAergic signaling and PPD development are dramatic perinatal changes in circulating levels of allopregnanolone, a neuroactive steroid (NAS) GABAA receptor (GABAAR)–positive allosteric modulator (PAM).29,30,31,32”
From Effect of Zuranolone vs Placebo in Postpartum Depression (2021) · cites this paper as [29]
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Meltzer-Brody, S., Colquhoun, H., Riesenberg, R., Epperson, C. N., Deligiannidis, K. M., Rubinow, D. R., Li, H., Sankoh, A. J., Clemson, C., Schacterle, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31551-4 · Cited by 795
Pathophysiological mechanisms implicated in postpartum depression
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Self-citationPredictors of Postpartum Depression: A Comprehensive Review of the Last Decade of Evidence
Guintivano, J., Manuck, T. A., & Meltzer-Brody, S. E. (2018) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000368 · Cited by 338
Effect of Zuranolone vs Placebo in Postpartum Depression
Deligiannidis, K. M., Meltzer-Brody, S., Gunduz-Bruce, H., Doherty, J., Jonas, J., Li, S., Sankoh, A. J., Silber, C., Campbell, A. D., Werneburg, B., et al. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.1559 · Cited by 277
Brexanolone for postpartum depression: A meta-analysis of randomized controlled studies
Zheng, W., Cai, D.-B., Zheng, W., Sim, K., Ungvari, G. S., Peng, X.-J., Ning, Y., Wang, G., & Xiang, Y. (2019) · Psychiatry Research · doi:10.1016/j.psychres.2019.07.006 · Cited by 223
Metadata
- Authors
- Osborne, L. M., Gispen, F., Sanyal, A., Yenokyan, G., Meilman, S., & Payne, J. L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Osborne, Lauren M.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 79
- Pages
- 116-121
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC5420429
- OpenAlex
- W2588649755
- Cited by
- 175
- References
- 55
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 24 · 2023: 17 · 2022: 21 · 2021: 26 · 2020: 20 · 2019: 26 · 2018: 10 · 2017: 1
- FWCI
- 14.64
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH104262, K23MH074799, R01MH112704)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy-related medical research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- allopregnanolone, progesterone, postpartum depression, pregnancy, perinatal mood disorders, progesterone metabolites, second trimester, third trimester, risk prediction
- MeSH terms
- Adolescent, Adult, Female, Humans, Middle Aged, Predictive Value of Tests, Pregnancy, Pregnancy Trimester, Third, Pregnanolone, Progesterone, Depression, Postpartum, Young Adult
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