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Cited by 459Maternal Mental Health During Pregnancy and PostpartumStress Responses and CortisolNeuroendocrine regulation and behavior

Pathophysiological mechanisms implicated in postpartum depression

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Payne, Jennifer L., Maguire, Jamie·2019·Frontiers in Neuroendocrinology
DOI 10.1016/j.yfrne.2018.12.001PMC PMC6370514
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Abstract

This review aims to summarize the diverse proposed pathophysiological mechanisms contributing to postpartum depression, highlighting both clinical and basic science research findings. The risk factors for developing postpartum depression are discussed, which may provide insight into potential neurobiological underpinnings. The evidence supporting a role for neuroendocrine changes, neuroinflammation, neurotransmitter alterations, circuit dysfunction, and the involvement of genetics and epigenetics in the pathophysiology of postpartum depression are discussed. This review integrates clinical and preclinical findings and highlights the diversity in the patient population, in which numerous pathophysiological changes may contribute to this disorder. Finally, we attempt to integrate these findings to understand how diverse neurobiological changes may contribute to a common pathological phenotype. This review is meant to serve as a comprehensive resource reviewing the proposed pathophysiological mechanisms underlying postpartum depression.

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  • The pathophysiology of postpartum depression is likely multifactorial, with evidence supporting a role for disruption of perinatal GABA signaling.

    “The pathophysiology of PPD is likely multifactorial,26,27 with evidence supporting a role for disruption of perinatal γ-aminobutyric acid (GABA) signaling, the major inhibitory signaling pathway of the central nervous system.28”

    From Effect of Zuranolone vs Placebo in Postpartum Depression (2021) · cites this paper as [26]

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Authors
Payne, J. L., & Maguire, J.
Affiliations
  • Johns Hopkins University (US)
  • Tufts University (US)
Corresponding author
Maguire, Jamie
ORCID
Venue
Frontiers in Neuroendocrinology
Publisher
Elsevier BV
Published
2019-01
Volume
52
Pages
165-180
ISSN
0091-3022 (ISSN-L)
DOI
10.1016/j.yfrne.2018.12.001
PMC
PMC6370514
OpenAlex
W2905455133
Cited by
459
References
22
Citations by year
2026: 59 · 2025: 81 · 2024: 86 · 2023: 72 · 2022: 66 · 2021: 41 · 2020: 41 · 2019: 12 · 2018: 1
FWCI
4.31
Type
journal article
Language
en
Open access
Licence
Locations
  • Frontiers in Neuroendocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute on Alcohol Abuse and Alcoholism (R01AA026256)
  • National Institute of Mental Health (R01MH104262, R01MH112704)
  • National Institute of Neurological Disorders and Stroke (R01NS073574, R01NS102937)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
postpartum depression, pathophysiology, neuroendocrine changes, neuroinflammation, neurotransmitter alterations, neural circuit dysfunction, genetic risk factors, epigenetics, risk factors, neurobiological mechanisms
MeSH terms
Animals, Female, Humans, Hypothalamo-Hypophyseal System, Inflammation, Pituitary-Adrenal System, Depression, Postpartum, Epigenesis, Genetic

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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