Impact of maltreatment on depressive symptoms in young male adults: The mediating and moderating role of cortisol stress response and coping strategies
Abstract
Background Converging evidence suggests that maltreated children suffer from depression at an early age and experience recurrent episodes of depression that persist over longer periods of time. However, the stress-related mechanisms hypothesized to be implicated in these associations remain to be specified. The present study tested the mediating and moderating roles of acute cortisol response to stress and coping strategies in the association between child maltreatment and depressive symptoms in early adulthood. Methods Data from 156 men aged 18 to 35 years (n = 56 maltreated) were collected using self-reported questionnaires assessing child maltreatment, depressive symptomatology and coping strategies. Cortisol was measured in response to the "Trier Social Stress Test" (TSST). Results Although acute cortisol response to stress did not mediate the maltreatment-depressive symptoms association, a moderation effect was found. Child maltreatment was associated with higher risk of depressive symptoms among participants with a higher cortisol response to stress, but not for those with moderate-to-lower cortisol responses. Additionally, maltreated participants reported more depressive symptoms, an association that was partly explained by their higher use of emotion-oriented coping (mediation). Finally, maltreated individuals who reported using less task-oriented coping had greater depressive symptomatology than those who adopted this coping strategy more frequently (moderation). Con…
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A cohort study found positive association between greater depressive symptoms, childhood maltreatment and higher cortisol levels following a TSST.
“In contrast, a cohort study found positive association between greater depressive symptoms, childhood maltreatment and higher cortisol levels following a TSST (166).”
From Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis (2022) · cites this paper as [166]
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Childhood Trauma, the HPA Axis and Psychiatric Illnesses: A Targeted Literature Synthesis
Murphy, F., Nasa, A., Cullinane, D., Raajakesary, K., Gazzaz, A., Sooknarine, V., Haines, M., Roman, E., Kelly, L., O'Neill, A., et al. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.748372 · Cited by 181 · see citing works
“Lower cortisol and ACTH responses were shown following the TSST in children with comorbid MDD and PTSD; however, adults with PTSD commencing in adulthood and those with social anxiety disorder (SAD) showed no differences.”
ResultInfluential
- Authors
- Cantave, C. Y., Langevin, S., Marin, M.-F., Brendgen, M., Lupien, S., & Ouellet-Morin, I.
- Affiliations
- Université de Montréal (CA)
- Université du Québec à Montréal (CA)
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 103
- Pages
- 41-48
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2906011511
- Cited by
- 28
- References
- 7
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 2 · 2019: 2
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Harry Frank Guggenheim Foundation
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- child abuse, depressive symptoms, cortisol stress response, coping strategies, emotion-focused coping, task-oriented coping, hypothalamic-pituitary-adrenal axis, young men, early adulthood, Trier Social Stress Test, mediation, moderation
- MeSH terms
- Adverse Childhood Experiences, Adaptation, Psychological, Adolescent, Adult, Child Abuse, Depression, Depressive Disorder, Emotions, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Pituitary-Adrenal System, Surveys and Questionnaires, Risk Factors, Saliva, Stress, Psychological, Young Adult, Self Report
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