The DOI matches its Crossref record; 277 of the 277 references it cites were found in a registry or an index.
Accelerating research on biological aging and mental health: Current challenges and future directions.
Open accessAbstract
Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential strategies to accelerate progress in this field. This effort requires the interaction of scientists across disciplines - including biology, psychiatry, psychology, and epidemiology; and across levels of analysis that emphasize different outcome measures - functional capacity, physiological, cellular, and molecular. Dialogues across disciplines and levels of analysis naturally lead to new opportunities for discovery but also to stimulating challenges. Some important challenges consist of 1) establishing the best objective and predictive biological age indicators or combinations of indicators, 2) identifying the basis for inter-individual differences in the rate of biological aging, and 3) examining to what extent interventions can delay, halt or temporarily reverse aging trajectories. Discovering how psychological states influence biological aging, and vice versa, has the potential to create novel and exciting opportunities for healthcare and possibly yield insights into the fundamental mechanisms that drive human aging.
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“biological measures, such as telomere length are related to aging and differences in such biological marker has been coupled with differences in the prevalence of psychiatric, cognitive, and somatic conditions”
From Evaluation of a Novel Psychological Intervention Tailored for Patients With Early Cognitive Impairment (PIPCI): Study Protocol of a Randomized Controlled Trial (2020) · cites this paper as Han et al., 2019
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Metadata
- Authors
- Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon, S. H., & Picard, M.
- Affiliations
- Amsterdam Neuroscience (NL)
- Amsterdam Public Health (NL)
- Brown University (US)
- University of California, San Francisco (US)
- Uppsala University (SE)
- University Medical Center Utrecht (NL)
- Tilburg University (NL)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Picard, Martin
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 106
- Pages
- 293-311
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC6589133
- OpenAlex
- W2929049496
- Cited by
- 104
- References
- 275
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 17 · 2023: 17 · 2022: 22 · 2021: 11 · 2020: 6 · 2019: 4
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Psychoneuroendocrinology (publishedVersion)
- Research portal (Tilburg University) (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- Nathaniel Wharton Fund
- National Institutes of Health (GM119793, MH113011, MH083784, MH101107, HD086487)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- biological aging, mental health, psychological stress, mental illness, aging interventions, accelerated aging, multidisciplinary research, levels of analysis
- MeSH terms
- Aging, Mental Disorders, Humans, Mental Health, Stress, Psychological
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