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Accelerating research on biological aging and mental health: Current challenges and future directions.
Open accessAbstract
Aging is associated with complex biological changes that can be accelerated, slowed, or even temporarily reversed by biological and non-biological factors. This article focuses on the link between biological aging, psychological stressors, and mental illness. Rather than comprehensively reviewing this rapidly expanding field, we highlight challenges in this area of research and propose potential strategies to accelerate progress in this field. This effort requires the interaction of scientists across disciplines - including biology, psychiatry, psychology, and epidemiology; and across levels of analysis that emphasize different outcome measures - functional capacity, physiological, cellular, and molecular. Dialogues across disciplines and levels of analysis naturally lead to new opportunities for discovery but also to stimulating challenges. Some important challenges consist of 1) establishing the best objective and predictive biological age indicators or combinations of indicators, 2) identifying the basis for inter-individual differences in the rate of biological aging, and 3) examining to what extent interventions can delay, halt or temporarily reverse aging trajectories. Discovering how psychological states influence biological aging, and vice versa, has the potential to create novel and exciting opportunities for healthcare and possibly yield insights into the fundamental mechanisms that drive human aging.
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“biological measures, such as telomere length are related to aging and differences in such biological marker has been coupled with differences in the prevalence of psychiatric, cognitive, and somatic conditions”
From Evaluation of a Novel Psychological Intervention Tailored for Patients With Early Cognitive Impairment (PIPCI): Study Protocol of a Randomized Controlled Trial (2020) · cites this paper as Han et al., 2019
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Work-related stress and burnout: Is epigenetic aging the missing link?
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“Despite increasing interest in the relationship between work-related stress, epigenetic signatures, and burnout [112, 113], longitudinal investigations remain scarce .”
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Editorial: Childhood Stress and Psychopathology: It’s Not Too Early to Look at Biological Aging
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Mental Disorders Are Associated With Leukocytes Telomere Shortening Among People Who Inject Drugs
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The accelerated organ senescence and proteotoxicity in thyrotoxicosis mice
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Advances in Geriatrics and Gerontology - Challenges of the New Millennium
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The Complex Relationship Between Early-Life Stress and Cellular Aging
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“bolic dysregulation, and mitochondrial allostatic load [as further reviewed in (1,2)].”
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“ageing also represents a success of human progress, provided that it is accompanied by actions 10 promoting healthy and active ageing that promotes functional capacity, social contribution and 11 quality of life in old age [5, 8].”
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Epigenetics in neurobehavioral disease
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“Interestingly, it was reported that the analysis of variations in telomere length and mitochondrial function can provide a reliable indication of the systemic effects associated with mental well-being [14,15].”
BackgroundA Psychoneuroimmunological Reading of Jane Austen’s Persuasion in the Context of Bodily Aging
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“Han et al. (2019, 294–95) claim that bio‑ logical age indicators “are indeed…sensitive to psychological states, namely stress and psychopathology,” which can directly impact organic tissues like the skin.”
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Einfluss biopsychosozialer Faktoren als Moderatoren des Trainingseffekts
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“It is understood that, along with the biological changes inherent to aging, social isolation, depression, and low self-esteem can occur, which directly impact the mental health of older adults (Han et al., 2019).”
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“LE8, although comprehensive in physiological domains, does not account for mental health, which is increasingly recognized as a core component of aging and cognitive function [24, 25].”
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Epigenetic aging and cancer incidence in a German cohort of older adults
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Metadata
- Authors
- Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon, S. H., & Picard, M.
- Affiliations
- Amsterdam Neuroscience (NL)
- Amsterdam Public Health (NL)
- Brown University (US)
- University of California, San Francisco (US)
- Uppsala University (SE)
- University Medical Center Utrecht (NL)
- Tilburg University (NL)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Picard, Martin
- ORCID
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 106
- Pages
- 293-311
- ISSN
- 0306-4530 (ISSN-L)
- PMC
- PMC6589133
- OpenAlex
- W2929049496
- Cited by
- 104
- References
- 275
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 17 · 2023: 17 · 2022: 22 · 2021: 11 · 2020: 6 · 2019: 4
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- Locations
- Psychoneuroendocrinology (publishedVersion)
- Research portal (Tilburg University) (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- eScholarship (California Digital Library) (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion)
- Funders
- Nathaniel Wharton Fund
- National Institutes of Health (GM119793, MH113011, MH083784, MH101107, HD086487)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Social Sciences › Psychology › Developmental and Educational Psychology › Aging and Gerontology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Keywords
- biological aging, mental health, psychological stress, mental illness, aging interventions, accelerated aging, multidisciplinary research, levels of analysis
- MeSH terms
- Aging, Mental Disorders, Humans, Mental Health, Stress, Psychological
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