Mellon, Synthia H.

Neurosteroids: biosynthesis and function of these novel neuromodulators

Compagnone, N. A., & Mellon, S. H. (2000) · Frontiers in Neuroendocrinology

Neuroscience and Neuropharmacology ResearchPharmacological Receptor Mechanisms and Effects

Cited by 820

Neurobiological and neuropsychiatric effects of dehydroepiandrosterone (DHEA) and DHEA sulfate (DHEAS)

Maninger, N., Wolkowitz, O. M., Reus, V. I., Epel, E. S., & Mellon, S. H. (2009) · Frontiers in Neuroendocrinology

Stress Responses and CortisolHormonal and reproductive studies

Cited by 769

Neurosteroids: biochemistry and clinical significance

Mellon, S. H., & Griffin, L. D. (2002) · Trends in Endocrinology & Metabolism

Neuroscience and Neuropharmacology ResearchEstrogen and related hormone effects

Cited by 538

Oxidative stress, inflammation and treatment response in major depression

Lindqvist, D., Dhabhar, F. S., James, S. J., Hough, C. M., Jain, F. A., Bersani, F. S., Reus, V. I., Verhoeven, J. E., Epel, E. S., Mahan, L., et al. (2017) · Psychoneuroendocrinology

Tryptophan and brain disordersTreatment of Major Depression

Cited by 473

Analyses and comparisons of telomerase activity and telomere length in human T and B cells: Insights for epidemiology of telomere maintenance

Lin, J., Epel, E., Cheon, J., Kroenke, C., Sinclair, E., Bigos, M., Wolkowitz, O., Mellon, S., & Blackburn, E. (2010) · Journal of Immunological Methods

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 426

Leukocyte Telomere Length in Major Depression: Correlations with Chronicity, Inflammation and Oxidative Stress - Preliminary Findings

Wolkowitz, O. M., Mellon, S. H., Epel, E. S., Lin, J., Dhabhar, F. S., Su, Y., Reus, V. I., Rosser, R., Burke, H. M., Kupferman, E., et al. (2011) · PLoS ONE

Telomeres, Telomerase, and SenescenceStress Responses and Cortisol

Cited by 421

Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain

Mellon, S. H., & Deschepper, C. F. (1993) · Brain Research

Estrogen and related hormone effectsNeuroscience and Neuropharmacology Research

Cited by 398

Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone

Griffin, L. D., Gong, W., Verot, L., & Mellon, S. H. (2004) · Nature Medicine

Lysosomal Storage Disorders ResearchGlycogen Storage Diseases and Myoclonus

Cited by 395

Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes

Griffin, L. D., & Mellon, S. H. (1999) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchStress Responses and Cortisol

Cited by 387

Dehydroepiandrosterone: a potential signalling molecule for neocortical organization during development

Compagnone, N. A., & Mellon, S. H. (1998) · Proceedings of the National Academy of Sciences

Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 327

Depression gets old fast: do stress and depression accelerate cell aging?

Wolkowitz, O. M., Epel, E. S., Reus, V. I., & Mellon, S. H. (2010) · Depression and Anxiety

Stress Responses and CortisolTryptophan and brain disorders

Cited by 298

Psychiatric disorders and leukocyte telomere length: Underlying mechanisms linking mental illness with cellular aging

Lindqvist, D., Epel, E. S., Mellon, S. H., Penninx, B. W., Révész, D., Verhoeven, J. E., Reus, V. I., Lin, J., Mahan, L., Hough, C. M., et al. (2015) · Neuroscience & Biobehavioral Reviews

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 285

Dysregulated relationship of inflammation and oxidative stress in major depression

Rawdin, B. J., Mellon, S. H., Dhabhar, F. S., Epel, E. S., Puterman, E., Su, Y., Burke, H. M., Reus, V. I., Rosser, R., Hamilton, S. P., et al. (2013) · Brain, Behavior, and Immunity

Tryptophan and brain disordersTreatment of Major Depression

Cited by 255

Low serum IL-10 concentrations and loss of regulatory association between IL-6 and IL-10 in adults with major depression

Dhabhar, F. S., Burke, H. M., Epel, E. S., Mellon, S. H., Rosser, R., Reus, V. I., & Wolkowitz, O. M. (2009) · Journal of Psychiatric Research

Tryptophan and brain disordersStress Responses and Cortisol

Cited by 225

Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress

Lindqvist, D., Wolkowitz, O. M., Mellon, S., Yehuda, R., Flory, J. D., Henn-Haase, C., Bierer, L. M., Abu-Amara, D., Coy, M., Neylan, T. C., et al. (2014) · Brain, Behavior, and Immunity

Posttraumatic Stress Disorder ResearchStress Responses and Cortisol

Cited by 213

Neurosteroid regulation of central nervous system development

Mellon, S. H. (2007) · Pharmacology & Therapeutics

Neuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Cited by 209

Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system

Compagnone, N. A., Bulfone, A., Rubenstein, J. L., & Mellon, S. H. (1995) · Endocrinology

Neuroscience and Neuropharmacology ResearchEstrogen and related hormone effects

Cited by 201

Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder

Lindqvist, D., Wolkowitz, O. M., Picard, M., Ohlsson, L., Bersani, F. S., Fernström, J., Westrin, Å., Hough, C. M., Lin, J., Reus, V. I., et al. (2018) · Neuropsychopharmacology

Mitochondrial Function and PathologyTreatment of Major Depression

Cited by 188

Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder

Mellon, S. H., Gautam, A., Hammamieh, R., Jett, M., & Wolkowitz, O. M. (2018) · Biological Psychiatry

Posttraumatic Stress Disorder ResearchStress Responses and Cortisol

Cited by 184

Expression of the steroidogenic enzyme P450scc in the central and peripheral nervous systems during rodent embryogenesis

Compagnone, N. A., Bulfone, A., Rubenstein, J. L., & Mellon, S. H. (1995) · Endocrinology

Sexual Differentiation and DisordersNeurogenesis and neuroplasticity mechanisms

Cited by 156

Protein phosphatase 2A and phosphoprotein SET regulate androgen production by P450c17

Pandey, A. V., Mellon, S. H., & Miller, W. L. (2003) · Journal of Biological Chemistry

Adrenal Hormones and DisordersHormonal Regulation and Hypertension

Cited by 137

Mitogenic action, regulation, and localization of insulin-like growth factors in the human fetal adrenal gland.

Mesiano, S., Mellon, S. H., & Jaffe, R. B. (1993) · The Journal of Clinical Endocrinology & Metabolism

Growth Hormone and Insulin-like Growth FactorsAdrenal Hormones and Disorders

Cited by 135

Extraadrenal steroid 21-hydroxylation is not mediated by P450c21.

Mellon, S. H., & Miller, W. L. (1989) · Journal of Clinical Investigation

Adrenal Hormones and DisordersHormonal Regulation and Hypertension

Cited by 121

Increased pro-inflammatory milieu in combat related PTSD – A new cohort replication study

Lindqvist, D., Dhabhar, F. S., Mellon, S. H., Yehuda, R., Grenon, S. M., Flory, J. D., Bierer, L. M., Abu-Amara, D., Coy, M., Makotkine, I., et al. (2017) · Brain, Behavior, and Immunity

Posttraumatic Stress Disorder ResearchStress Responses and Cortisol

Cited by 114