Complement activation: a critical mediator of adverse fetal outcomes in placental malaria?
Abstract
Malaria infection is a significant risk factor for low birth weight outcomes in pregnancy. Despite efforts to define the molecular mechanisms that cause low birth weight as a result of intrauterine growth restriction, the roles of inflammation and mononuclear cells in the process are incompletely understood. Data from adverse pregnancy outcomes in humans and from murine models of pathological pregnancies suggest that C5a could be an important upstream regulator of placental angiogenesis, and excessive C5a could lead to functional placental insufficiency by impairing adequate vascularization of the placenta. Based on recent evidence, we hypothesize that complement factor C5a is a central initiator of poor birth outcomes associated with placental malaria by promoting mononuclear cell migration, activation and dysregulated angiogenesis.
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Although the exact mechanism has not been elucidated, low birth weight due to IUGR appears to be due to chronic infections that cause reduced foetal circulation and placental insufficiency.
“Although the exact mechanism has not been elucidated, it appears to be due to chronic infections that cause reduced foetal circulation and placental insufficiency.86”
From Malaria in pregnancy. (2013) · cites this paper as [86]
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- Authors
- Conroy, A. L., McDonald, C. R., Silver, K. L., Liles, W. C., & Kain, K. C.
- Affiliations
- University Health Network (CA)
- Venue
- Trends in Parasitology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 27
- Issue
- 7
- Pages
- 294-299
- ISSN
- 1471-4922 (ISSN-L)
- OpenAlex
- W1977981454
- Cited by
- 26
- References
- 6
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 7
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Parasitology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Malaria Research and Control
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Keywords
- complement activation, placental malaria, C5a, low birth weight, fetal growth restriction, placental insufficiency, placental angiogenesis, mononuclear cell migration, inflammation, adverse pregnancy outcomes, malaria in pregnancy
- MeSH terms
- Complement Activation, Female, Gene Expression Regulation, Humans, Placenta, Pregnancy, Pregnancy Outcome, Pregnancy Complications, Parasitic, Complement C5a
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