Airway smooth muscle as an immunomodulatory cell

Damera, Gautam; Tliba, Omar; Panettieri, Reynold A.

doi:10.1016/j.pupt.2008.12.006

Cited by 98Asthma and respiratory diseasesChronic Obstructive Pulmonary Disease (COPD) ResearchOccupational exposure and asthma

Airway smooth muscle as an immunomodulatory cell

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Damera, Gautam, Tliba, Omar, Panettieri, Reynold A.·2009·Pulmonary Pharmacology & Therapeutics

DOI 10.1016/j.pupt.2008.12.006PMC PMC2736352

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Abstract

Although pivotal in regulating bronchomotor tone in asthma, airway smooth muscle (ASM) also modulates airway inflammation in asthma. ASM myocytes secrete or express a wide array of immunomodulatory mediators in response to extracellular stimuli, and in chronic severe asthma, increases in ASM mass may also render the airway irreversibly obstructed. Although the mechanisms by which ASM secretes cytokines and chemokines are shared with those regulating immune cells, there exist unique ASM signaling pathways that may provide novel therapeutic targets. This review provides an overview of our current understanding of the proliferative as well as synthetic properties of ASM.

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Structural changes, such as subepithelial collagen deposition, goblet cell and mucous gland hyperplasia, as well as ASM hypertrophy and hyperplasia, illustrate that remodeling of airways occurs in asthma patients.
“Structural changes, such as subepithelial collagen deposition, goblet cell and mucous gland hyperplasia, as well as ASM hypertrophy and hyperplasia, illustrate that remodeling of airways occurs in asthma patients (98, 99).”
From Aging and Lung Disease (2020) · cites this paper as [99]

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Authors: Damera, G., Tliba, O., & Panettieri, R. A.
Affiliations: University of Pennsylvania (US)
Thomas Jefferson University (US)
Corresponding author: Panettieri, Reynold A.
ORCID: Damera, Gautam
Panettieri, Reynold A.
Venue: Pulmonary Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2009-10
Volume: 22
Issue: 5
Pages: 353-359
ISSN: 1094-5539 (ISSN-L)
DOI: 10.1016/j.pupt.2008.12.006
PMC: PMC2736352
OpenAlex: W2132031140
Cited by: 98
References: 88
Citations by year: 2024: 6 · 2023: 4 · 2022: 1 · 2021: 3 · 2020: 12 · 2019: 8 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 4 · 2013: 7 · 2012: 9
FWCI: 5.21
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pulmonary Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
The Medicine Forum (submittedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL064063, R01HL077735, R01HL080676, R01HL081824, R00HL089409)
National Institute of Environmental Health Sciences (P30ES013508)
Topics: Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
Keywords: airway smooth muscle, asthma, airway inflammation, immunomodulation, cytokine production, chemokines, smooth muscle cell proliferation, smooth muscle contraction, airway remodeling, signaling pathways, therapeutic target
MeSH terms: Asthma, Bronchi, Glucocorticoids, Humans, Immunologic Factors, Muscle, Smooth, Respiratory System, Cell Adhesion Molecules, Cytokines, Models, Immunological, Chemokines, Myocytes, Smooth Muscle, Toll-Like Receptors

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Airway smooth muscle as an immunomodulatory cell

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