Myocarditis following COVID-19 vaccination
Open accessAbstract
The coronavirus disease 2019 (COVID-19) vaccination frequently leads to minor side-effects, that may be more intense after the second dose, but more serious side effects have been reported. We report a case of a 24-year-old man who presented to the hospital with acute substernal chest pain, 4 days after his second COVID-19 Moderna vaccination. Laboratory studies revealed elevated troponins and negative viral serologies. Cardiac magnetic resonance imaging (cMRI) demonstrated edema and delayed gadolinium enhancement of the left ventricle in a midmyocardial and epicardial distribution. The patient was diagnosed with myocarditis following Moderna vaccination. Our case report raises concern that myocarditis is a rare side effect of COVID-19 vaccine. Despite our report, it appears that there is a significantly higher risk of cardiac involvement from COVID-19 infection compared to COVID-19 vaccination.
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Multiple cases of myocarditis after Covid-19 vaccination have recently been reported in the literature.
“multiple cases of myocarditis after Covid-19 vaccination have recently been reported in the literature,21-25”
From Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting (2021) · cites this paper as [24]
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Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper
Friedrich, M. G., Sechtem, U. P., Schulz‐Menger, J., Holmvang, G., Alakija, P., Cooper, L. T., White, J. A., Abdel‐Aty, H., Gutberlet, M., Prasad, S. K., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.02.007 · Cited by 2,495 · see citing works
Vaccination greatly reduces disease, disability, death and inequity worldwide
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COVID-19 pandemic and troponin: indirect myocardial injury, myocardial inflammation or myocarditis?
Imazio, M., Klingel, K., Kindermann, I., Brucato, A. L., Rosa, F. G. D., Adler, Y., & Ferrari, G. M. D. (2020) · Heart · doi:10.1136/heartjnl-2020-317186 · Cited by 222 · see citing works
Thrombosis after covid-19 vaccination
Hunter, P. R. (2021) · BMJ · doi:10.1136/bmj.n958 · Cited by 129 · see citing works
Kim, Y., Bae, J.-I., Ryoo, S. M., & Kim, W. Y. (2018) · Acute and Critical Care · doi:10.4266/acc.2017.00045 · Cited by 34 · see citing works
Myocarditis secondary to smallpox vaccination
Keinath, K., Church, T. L., Kurth, B. J., & Hulten, E. A. (2018) · BMJ Case Reports · doi:10.1136/bcr-2017-223523 · Cited by 31 · see citing works
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Safety of the BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Setting
Barda, N., Dagan, N., Ben-Shlomo, Y., Kepten, E., Waxman, J., Ohana, R., Hernán, M. A., Lipsitch, M., Kohane, I., Netzer, D., et al. (2021) · New England Journal of Medicine · doi:10.1056/nejmoa2110475 · Cited by 1,027 · see citing works
- Authors
- Albert, E., Aurigemma, G., Saucedo, J., & Gerson, D. S.
- Affiliations
- University of Massachusetts Chan Medical School (US)
- UMass Memorial Medical Center (US)
- Corresponding author
- Albert, Elisabeth
- ORCID
- Aurigemma, Gerard
- Venue
- Radiology Case Reports
- Publisher
- Elsevier BV
- Published
- 2021-08
- Volume
- 16
- Issue
- 8
- Pages
- 2142-2145
- ISSN
- 1930-0433 (ISSN-L)
- PMC
- PMC8130498
- OpenAlex
- W3162328249
- Cited by
- 127
- References
- 7
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 10 · 2023: 17 · 2022: 46 · 2021: 48
- FWCI
- 20.28
- Type
- journal article
- Language
- en
- Update notices
- erratum (2023-03-01)
- Open access
- gold
- doi.org
- Licence
- Locations
- Radiology Case Reports (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion, cc-by-nc-nd)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- myocarditis, COVID-19 vaccination, Moderna vaccine, vaccine adverse events, chest pain, troponin elevation, cardiac magnetic resonance imaging, late gadolinium enhancement, myocardial injury
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