Myocarditis
Abstract
Viral myocarditis remains a prominent infectious-inflammatory disease for patients throughout the lifespan. The condition presents several challenges including varied modes of clinical presentation, a range of timepoints when patients come to attention, a diversity of approaches to diagnosis, a spectrum of clinical courses, and unsettled perspectives on therapeutics in different patient settings and in the face of different viral pathogens. In this review, we examine current knowledge about viral heart disease and especially provide information on evolving understanding of mechanisms of disease and efforts by investigators to identify and evaluate potential therapeutic avenues for intervention.
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The pathological progression of myocarditis consists of 3 phases: acute inflammatory, subacute inflammatory, and chronic myopathy.
“The pathological progression of myocarditis consists of 3 phases: acute inflammatory, subacute inflammatory, and chronic myopathy. 1”
From Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. (2020) · cites this paper as [1]
The EAM pathway is not fully equivalent to that of virus-induced myocarditis.
“The EAM pathway is not fully equivalent to that of virus-induced myocarditis, 1”
From Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis. (2020) · cites this paper as [1]
Cites
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Progress in antisense technology
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Learning from myocarditis: mimicry, chaos and black holes
Rose, N. R. (2014) · F1000Prime Reports · doi:10.12703/p6-25 · Cited by 44 · see citing works
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Ammirati, E., Frigerio, M., Adler, E. D., Basso, C., Birnie, D. H., Brambatti, M., Friedrich, M. G., Klingel, K., Lehtonen, J., Moslehi, J. J., et al. (2020) · Circulation: Heart Failure · doi:10.1161/circheartfailure.120.007405 · Cited by 811 · see citing works
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Systematic Review of COVID-19 Related Myocarditis: Insights on Management and Outcome
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Single-Cell RNA Sequencing to Dissect the Immunological Network of Autoimmune Myocarditis.
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Sex and gender differences in myocarditis and dilated cardiomyopathy: An update
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Myocarditis following COVID-19 vaccination
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The Cardiac Microenvironment Instructs Divergent Monocyte Fates and Functions in Myocarditis
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Basavalingappa, R. H., Arumugam, R., Lasrado, N., Yalaka, B., Massilamany, C., Gangaplara, A., Riethoven, J.-J., Xiang, S.-H., Steffen, D., & Reddy, J. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.06.017 · Cited by 29 · see citing works
- Authors
- Fung, G., Luo, H., Qiu, Y., Yang, D., & McManus, B.
- Affiliations
- University of British Columbia (CA)
- Venue
- Circulation Research
- Published
- 2016-02-05
- Volume
- 118
- Issue
- 3
- Pages
- 496-514
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W4211186615
- Cited by
- 444
- References
- 7
- Citations by year
- 2026: 15 · 2025: 28 · 2024: 44 · 2023: 59 · 2022: 63 · 2021: 66 · 2020: 84 · 2019: 36 · 2018: 29 · 2017: 14 · 2016: 5
- FWCI
- 4.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Health Sciences › Medicine › Surgery › Kawasaki Disease and Coronary Complications
- Keywords
- viral myocarditis, viral heart disease, pathogenesis, clinical features, diagnosis, therapeutics, inflammatory cardiomyopathy
- MeSH terms
- Animals, Biopsy, Diagnostic Imaging, Electrocardiography, Heart, Humans, Myocarditis, Predictive Value of Tests, Prognosis, Risk Factors, Viruses, Host-Pathogen Interactions
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