The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Discovery of the cancer stem cell related determinants of radioresistance
Open accessAbstract
Tumors are known to be heterogeneous containing a dynamic mixture of phenotypically and functionally different tumor cells. The two concepts attempting to explain the origin of intratumor heterogeneity are the cancer stem cell hypothesis and the clonal evolution model. The stochastic model argues that tumors are biologically homogenous and all cancer cells within the tumor have equal ability to propagate the tumor growth depending on continuing mutations and selective pressure. By contrast, the stem cells model suggests that cancer heterogeneity is due to the hierarchy that originates from a small population of cancer stem cells (CSCs) which are biologically distinct from the bulk tumor and possesses self-renewal, tumorigenic and multilineage potential. Although these two hypotheses have been discussed for a long time as mutually exclusive explanations of tumor heterogeneity, they are easily reconciled serving as a driving force of cancer evolution and diversity. Recent discovery of the cancer cell plasticity and heterogeneity makes the CSC population a moving target that could be hard to track and eradicate. Understanding the signaling mechanisms regulating CSCs during the course of cancer treatment can be indispensable for the optimization of current treatment strategies.
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Cites
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The Intricate Role of CXCR4 in Cancer
(2014) · Advances in Cancer Research · doi:10.1016/b978-0-12-411638-2.00002-1 · Cited by 672
ZEB1: At the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance
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Cancer stem cells: advances in knowledge and implications for cancer therapy
Chu, X., Tian, W., Ning, J., Xiao, G., Zhou, Y., Wang, Z., Zhai, Z., Tanzhu, G., Yang, J., & Zhou, R. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01851-y · Cited by 553
Molecular mechanisms of tumor resistance to radiotherapy
Wu, Y., Song, Y., Wang, R., & Wang, T. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01801-2 · Cited by 527
A role for cancer stem cells in therapy resistance: Cellular and molecular mechanisms
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Self-citation
Metadata
- Authors
- Peitzsch, C., Kurth, I., Kunz-Schughart, L., Baumann, M., & Dubrovska, A.
- Venue
- Radiotherapy and Oncology
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 108
- Issue
- 3
- Pages
- 378-387
- ISSN
- 0167-8140 (ISSN-L)
- OpenAlex
- W2022168604
- Cited by
- 189
- References
- 9
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Peitzsch, C., Kurth, I., Kunz-Schughart, L., Baumann, M., & Dubrovska, A. (2013). Discovery of the cancer stem cell related determinants of radioresistance. Radiotherapy and Oncology. https://doi.org/10.1016/j.radonc.2013.06.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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