Asymptomatic adenomyosis and embryo implantation in IVF cycles
Abstract
Research on the effect of adenomyosis on the rate of success of IVF is controversial. Differences in study design, study power, criteria and instrument used to diagnose adenomyosis and choice of controls may explain these discrepancies. To establish whether embryo implantation is impaired in women with adenomyosis, women scheduled for IVF were prospectively evaluated for the presence of adenomyosis and whether this condition affected embryo implantation. Forty-nine women with adenomyosis diagnosed at transvaginal ultrasound with no abnormal uterine bleeding were recruited. They were matched for study period, age, day of embryo transfer and number of transferred embryos to 49 controls without the disease. In women with adenomyosis, 24 out of 76 embryos transferred implanted (32%); this occurred in 16 out of 76 (21%) in unaffected controls. The crude odds ratio of implantation in affected women was 1.73 (95% CI 0.83 to 3.60). The odds ratio adjusted for body mass index (the unique variable found to differ at univariate analysis) was 1.78 (95% CI 0.85 to 3.77). In conclusion, implantation rate is not impaired in asymptomatic women who are diagnosed with adenomyosis at transvaginal sonography. Affected women can be reassured about the effect of this condition on their chances of success.
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ART data accumulated in recent years do not confirm that endometrial receptivity is altered in adenomyosis or endometriosis.
“Indeed, as discussed further in this article, ART data accumulated in the last years fail to confirm that endometrial receptivity is altered in adenomyosis (27) and endometriosis (28).”
From Endometrial receptivity in adenomyosis and/or endometriosis (2023) · cites this paper as [27]
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- Authors
- Benaglia, L., Cardellicchio, L., Leonardi, M., Faulisi, S., Vercellini, P., Paffoni, A., Somigliana, E., & Fedele, L.
- Affiliations
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- University of Milan (IT)
- Corresponding author
- Benaglia, Laura
- Venue
- Reproductive BioMedicine Online
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 29
- Issue
- 5
- Pages
- 606-611
- ISSN
- 1472-6483 (ISSN-L)
- OpenAlex
- W2092630215
- Cited by
- 90
- References
- 23
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 9 · 2023: 13 · 2022: 11 · 2021: 10 · 2020: 10 · 2019: 6 · 2018: 6 · 2017: 7 · 2016: 9 · 2015: 2
- FWCI
- 7.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Reproductive BioMedicine Online (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- adenomyosis, embryo implantation, in vitro fertilization, transvaginal ultrasound diagnosis, body mass index, IVF outcomes, endometrial receptivity
- MeSH terms
- Adult, Embryo Transfer, Female, Fertilization in Vitro, Humans, Infertility, Female, Embryo Implantation, Pregnancy, Pregnancy Outcome, Prospective Studies, Ultrasonography, Odds Ratio, Case-Control Studies, Treatment Outcome, Pregnancy Rate, Sperm Injections, Intracytoplasmic, Adenomyosis
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