Hormone therapy for intramural myoma-related infertility from ulipristal acetate to GnRH antagonist: a review
Open accessAbstract
Uterine fibroids may cause infertility, depending on their size and location according to the International Federation of Gynecology and Obstetrics classification. In this review, infertility relating to intramural myomas is evaluated. The mechanisms linking uterine fibroids and infertility are numerous: uterine cavity distortion (fibroids types 0, 1, 2, 2-5); impaired endometrial and myometrial blood supply; increased uterine contractility; hormonal, paracrine and molecular changes; impaired endometrial receptivity in gene expression (decrease in homeobox 10 [HOXA-10] expression); and thicker capsule. The negative effect of intramural myoma is related to myoma size and proximity of the uterine cavity. Therefore, a medical approach could be proposed to reduce the size of the myoma and push it back deep into the myometrium. The relevant medical treatments, including selective progesterone receptor modulator and gonadotrophin releasing hormone antagonist are reviewed. Even if the mystery surrounding intramural myomas remains, the development of new algorithms for intramural myoma-related infertility, and evaluation of the place of medical treatment as a primary approach are urgently needed. An algorithm, taking into account the mechanisms linking uterine fibroids and infertility, is proposed.
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SPRMs are not an option for endometriosis because they induce progesterone modulator-associated endometrial changes (PAECs) in ectopic foci and their efficacy is limited.
“among new drugs, selective progesterone receptor modulators (SPRMs) are not an option as they induce progesterone modulator-associated endometrial changes (PAECs) in ectopic foci and their efficacy is limited [89,90,91].”
From Endometriosis and Medical Therapy: From Progestogens to Progesterone Resistance to GnRH Antagonists: A Review (2021) · cites this paper as [90]
Cites
1 retracted
RETRACTED ARTICLE: Effects of the position of fibroids on fertility
Casini, M. L., Rossi, F., Agostini, R., & Unfer, V. (2006) · Gynecological Endocrinology · doi:10.1080/09513590600604673 · Cited by 340 · see citing works
RetractedHigh cumulative incidence of uterine leiomyoma in black and white women: Ultrasound evidence
Baird, D. D., Dunson, D. B., Hill, M. C., Cousins, D. S., & Schectman, J. M. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2003.99 · Cited by 2,437 · see citing works
Fibroids and infertility: an updated systematic review of the evidence
Pritts, E. A., Parker, W. H., & Olive, D. L. (2009) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.01.051 · Cited by 913 · see citing works
Uterine fibroid management: From the present to the future
Donnez, J., & Dolmans, M.-M. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmw023 · Cited by 780 · see citing works
Self-citationBulun, S. E. (2013) · New England Journal of Medicine · doi:10.1056/nejmra1209993 · Cited by 703 · see citing works
Ulipristal Acetate versus Placebo for Fibroid Treatment before Surgery
Donnez, J., Татарчук, Т. Ф., Bouchard, P., Pușcașiu, L., Zakharenko, N. F., Ivanova, T. V., Ugocsai, G., Mára, M., Jilla, M. P., Bestel, E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1103182 · Cited by 679 · see citing works
Self-citationMED12 , the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas
Mäkinen, N., Mehine, M. M., Tolvanen, J., Kaasinen, E., Li, Y., Lehtonen, H. J., Gentile, M., Yan, J., Enge, M., Taipale, M., et al. (2011) · Science · doi:10.1126/science.1208930 · Cited by 659 · see citing works
Ulipristal Acetate versus Leuprolide Acetate for Uterine Fibroids
Donnez, J., Tomaszewski, J., Vázquez, F., Bouchard, P., Lemieszczuk, B., Baró, F., Nouri, K., Selvaggi, L. E., Sodowski, K., Bestel, E., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1103180 · Cited by 604 · see citing works
Self-citationStewart, E. A. (2015) · New England Journal of Medicine · doi:10.1056/nejmcp1411029 · Cited by 404 · see citing works
Vannuccini, S., Clifton, V. L., Fraser, I. S., Taylor, H. S., Critchley, H., Giudice, L. C., & Petraglia, F. (2016) · Human Reproduction Update · doi:10.1093/humupd/dmv044 · Cited by 379 · see citing works
Pre-operative GnRH analogue therapy before hysterectomy or myomectomy for uterine fibroids
Lethaby, A. E., Vollenhoven, B. J., & Sowter, M. C. (2001) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000547 · Cited by 357 · see citing works
What are the implications of myomas on fertility?
Donnez, J., & Jadoul, P. (2002) · Human Reproduction · doi:10.1093/humrep/17.6.1424 · Cited by 351 · see citing works
Self-citationEpidemiology of Uterine Fibroids
Wise, L. A., & Laughlin-Tommaso, S. K. (2016) · Clinical Obstetrics & Gynecology · doi:10.1097/grf.0000000000000164 · Cited by 340 · see citing works
Sunkara, S. K., Khairy, M., El‐Toukhy, T., Khalaf, Y., & Coomarasamy, A. (2009) · Human Reproduction · doi:10.1093/humrep/dep396 · Cited by 332 · see citing works
Long-term treatment of uterine fibroids with ulipristal acetate☆
Donnez, J., Vázquez, F., Tomaszewski, J., Nouri, K., Bouchard, P., Fauser, B. C. J. M., Barlow, D. H., Palacios, S., Donnez, O., Bestel, E., et al. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.02.008 · Cited by 331 · see citing works
Self-citationHysteroscopic myomectomy: a comprehensive review of surgical techniques
Sardo, A. D. S., Mazzon, I., Bramante, S., Bettocchi, S., Bifulco, G., Guida, M., & Nappi, C. (2007) · Human Reproduction Update · doi:10.1093/humupd/dmm041 · Cited by 300 · see citing works
Uterine Fibroids: Diagnosis and Treatment.
de la Cruz, M. S. D., & Buchanan, E. M. (2017) · PubMed · Cited by 279 · see citing works
Antifibrinolytics for heavy menstrual bleeding
Bryant‐Smith, A., Lethaby, A. E., Farquhar, C. M., & Hickey, M. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000249.pub2 · Cited by 273 · see citing works
The Burden of Uterine Fibroids for African-American Women: Results of a National Survey
Stewart, E. A., Nicholson, W. K., Bradley, L., & Borah, B. J. (2013) · Journal of Women s Health · doi:10.1089/jwh.2013.4334 · Cited by 255 · see citing works
Antifibrinolytics for heavy menstrual bleeding
Lethaby, A. E., Farquhar, C. M., & Cooke, I. (2000) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000249 · Cited by 247 · see citing works
Tranexamic Acid Treatment for Heavy Menstrual Bleeding
Lukes, A. S., Moore, K. A., Muse, K. N., Gersten, J. K., Hecht, B. R., Edlund, M., Richter, H. E., Eder, S. E., Attia, G. R., Patrick, D. L., et al. (2010) · Obstetrics and Gynecology · doi:10.1097/aog.0b013e3181f20177 · Cited by 245 · see citing works
Rackow, B. W., & Taylor, H. S. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.03.029 · Cited by 239 · see citing works
The spectrum of endometrial pathology induced by progesterone receptor modulators
Mutter, G. L., Bergeron, C., Deligdisch, L., Ferenczy, A. S., Glant, M., Merino, M. J., Williams, A. R. W., & Blithe, D. (2008) · Modern Pathology · doi:10.1038/modpathol.2008.19 · Cited by 235 · see citing works
Bettocchi, S., Ceci, O. R., Nappi, L., Venere, R. D., Masciopinto, V., Pansini, V., Pinto, L., Santoro, A., & Cormio, G. (2004) · The Journal of the American Association of Gynecologic Laparoscopists · doi:10.1016/s1074-3804(05)60012-6 · Cited by 218 · see citing works
Efficacy and safety of repeated use of ulipristal acetate in uterine fibroids
Donnez, J., Hudecek, R., Donnez, O., Matule, D., Arhendt, H.-J., Zatik, J., Kasilovskiene, Z., Dumitrascu, M. C., Fernandez, H., Barlow, D. H., et al. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.10.038 · Cited by 216 · see citing works
Self-citationComplex networks of multiple factors in the pathogenesis of uterine leiomyoma
Islam, M. S., Protic, O., Stortoni, P., Grechi, G., Lamanna, P., Petraglia, F., Castellucci, M., & Ciarmela, P. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.03.007 · Cited by 213 · see citing works
Elagolix for Heavy Menstrual Bleeding in Women with Uterine Fibroids
Schlaff, W. D., Ackerman, R. T., Al-Hendy, A. A., Archer, D. F., Barnhart, K. T., Bradley, L. D., Carr, B. R., Feinberg, E. C., Hurtado, S. M., Kim, J. H., et al. (2020) · New England Journal of Medicine · doi:10.1056/nejmoa1904351 · Cited by 207 · see citing works
Genomics of uterine leiomyomas: insights from high-throughput sequencing
Mehine, M. M., Mäkinen, N., Heinonen, H.-R., Aaltonen, L. A., & Vahteristo, P. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.06.050 · Cited by 201 · see citing works
Uterine Leiomyoma: Available Medical Treatments and New Possible Therapeutic Options
Islam, M. S., Protic, O., Giannubilo, S. R., Toti, P., Tranquilli, A. L., Petraglia, F., Castellucci, M., & Ciarmela, P. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-3237 · Cited by 198 · see citing works
Why is Parity Protective for Uterine Fibroids?
Baird, D. D., & Dunson, D. B. (2003) · Epidemiology · doi:10.1097/01.ede.0000054360.61254.27 · Cited by 196 · see citing works
The role of progesterone signaling in the pathogenesis of uterine leiomyoma
Kim, J. J., & Sefton, E. C. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.05.044 · Cited by 191 · see citing works
Decreased pregnancy rate is linked to abnormal uterine peristalsis caused by intramural fibroids
Yoshino, O., Hayashi, T., Osuga, Y., Orisaka, M., Asada, H., Okuda, S., Hori, M., Furuya, M., Onuki, H., Sadoshima, Y., et al. (2010) · Human Reproduction · doi:10.1093/humrep/deq222 · Cited by 190 · see citing works
Lethaby, A. E., Vollenhoven, B. J., & Sowter, M. (2002) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/j.1471-0528.2002.01225.x · Cited by 185 · see citing works
Bouchard, P., Chabbert‐Buffet, N., & Fauser, B. C. J. M. (2011) · Fertility and Sterility · doi:10.1016/j.fertnstert.2011.08.021 · Cited by 183 · see citing works
Long-term medical management of uterine fibroids with ulipristal acetate
Donnez, J., Donnez, O., Matule, D., Ahrendt, H.-J., Hudeček, R., Zatik, J., Kasilovskienė, Ž., Dumitrașcu, M. C., Fernandez, H., Barlow, D. H., et al. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.09.032 · Cited by 172 · see citing works
Self-citationLethaby, A. E. (2002) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1016/s1470-0328(02)01925-0 · Cited by 168 · see citing works
Lasmar, R. B., Barrozo, P. R. M., Dias, R., & Oliveira, M. A. P. (2005) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2005.05.014 · Cited by 166 · see citing works
Williams, A. R. W., Bergeron, C., Barlow, D. H., & Ferenczy, A. S. (2012) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e318251035b · Cited by 154 · see citing works
Schild, R. L., Holthaus, S., d'Alquen, J., Fimmers, R., Dorn, C. H. V., van der Ven, H., & Hansmann, M. (2000) · Human Reproduction · doi:10.1093/humrep/15.1.89 · Cited by 149 · see citing works
Wise, L. A. (2004) · Human Reproduction · doi:10.1093/humrep/deh309 · Cited by 134 · see citing works
Review of New Office-Based Hysteroscopic Procedures 2003–2009
Sardo, A. D. S., Bettocchi, S., Spinelli, M., Guida, M., Nappi, L., Angioni, S. L., Fernandez, L. M. S., & Nappi, C. (2010) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2010.03.014 · Cited by 131 · see citing works
Intrauterine device use among women with uterine fibroids: a systematic review
Zapata, L. B., Whiteman, M. K., Tepper, N. K., Jamieson, D. J., Marchbanks, P. A., & Curtis, K. M. (2010) · Contraception · doi:10.1016/j.contraception.2010.02.011 · Cited by 126 · see citing works
Donnez, J., Taylor, H. S., Taylor, R. N., Akin, M. D., Tatarchuk, T. F., Wilk, K., Gotteland, J.-P., Lecomte, V., & Bestel, E. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.02.114 · Cited by 124 · see citing works
Self-citationWilliams, A. R. W., Critchley, H., Osei, J., Ingamells, S., Cameron, I. T., Han, C., & Chwalisż, K. (2007) · Human Reproduction · doi:10.1093/humrep/dem026 · Cited by 122 · see citing works
Tan, Y. H., & Lethaby, A. E. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd010241.pub2 · Cited by 115 · see citing works
What does ‘diagnostic hysteroscopy’ mean today? The role of the new techniques
Bettocchi, S., Nappi, L., Ceci, O. R., & Selvaggi, L. E. (2003) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/01.gco.0000084241.09900.c8 · Cited by 115 · see citing works
Donnez, J., Schrurs, B., Gillerot, S., Sandow, J., & Clerckx, F. (1989) · Fertility and Sterility · doi:10.1016/s0015-0282(16)60723-9 · Cited by 106 · see citing works
Self-citationOsuga, Y., Enya, K., Kudou, K., Tanimoto, M., & Hoshiai, H. (2019) · Obstetrics and Gynecology · doi:10.1097/aog.0000000000003141 · Cited by 97 · see citing works
Yan, L., Ding, L., Li, C., Wang, Y., Tang, R., & Chen, Z. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.11.023 · Cited by 93 · see citing works
Horcajadas, J. A., Goyri, E., Higón, M. A., Martínez-Conejero, J. A., Gambadauro, P., García, G., Meseguer, M., Simón, C., & Pellicer, A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0565 · Cited by 91 · see citing works
First series of 18 pregnancies after ulipristal acetate treatment for uterine fibroids
Luyckx, M., Squifflet, J.-L., Jadoul, P., Votino, R., Dolmans, M., & Donnez, J. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.1253 · Cited by 90 · see citing works
Self-citationMiura, S., Khan, K. N., Kitajima, M., Hiraki, K., Moriyama, S., Masuzaki, H., Samejima, T., Fujishita, A., & Ishimaru, T. (2006) · Human Reproduction · doi:10.1093/humrep/del205 · Cited by 89 · see citing works
In vivo mechanisms of uterine myoma volume reduction with ulipristal acetate treatment
Courtoy, G. E., Donnez, J., Marbaix, É., & Dolmans, M. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.04.025 · Cited by 87 · see citing works
Self-citationIntake of fruit, vegetables, and carotenoids in relation to risk of uterine leiomyomata
Wise, L. A., Radin, R. G., Palmer, J. R., Kumanyika, S., Boggs, D. A., & Rosenberg, L. A. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.016600 · Cited by 86 · see citing works
The FIGO classification of causes of abnormal uterine bleeding
Munro, M. G., Critchley, H., & Fraser, I. S. (2011) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2011.01.001 · Cited by 84 · see citing works
Literature Review on the Role of Uterine Fibroids in Endometrial Function
Ikhena, D. E., & Bulun, S. E. (2017) · Reproductive Sciences · doi:10.1177/1933719117725827 · Cited by 82 · see citing works
Fibroid growth and medical options for treatment
Chabbert‐Buffet, N., Esber, N., & Bouchard, P. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.07.1238 · Cited by 76 · see citing works
Fibroids: diagnosis and management
Lumsden, M. A., Hamoodi, I., Gupta, J. K., & Hickey, M. (2015) · BMJ · doi:10.1136/bmj.h4887 · Cited by 76 · see citing works
Orisaka, M., Kurokawa, T., Shukunami, K., Orisaka, S., Fukuda, M., Shinagawa, A., Fukuda, S., Ihara, N., Yamada, H., Itoh, H., et al. (2007) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2006.07.040 · Cited by 75 · see citing works
Kim, A., Jung, H., Choi, W. J., Hong, S. N., & Kim, H. Y. (2014) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/j.tjog.2013.05.007 · Cited by 72 · see citing works
Yan, L., Yu, Q., Zhang, Y., Guo, Z., Li, Z., Niu, J., & Ma, J. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.01.007 · Cited by 67 · see citing works
Christopoulos, G., Vlismas, A., Salim, R., Islam, R., Trew, G. H., & Lavery, S. A. (2016) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.14362 · Cited by 65 · see citing works
Doherty, L. F., & Taylor, H. S. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.12.099 · Cited by 63 · see citing works
Safety after extended repeated use of ulipristal acetate for uterine fibroids
Fauser, B. C. J. M., Donnez, J., Bouchard, P., Barlow, D. H., Vázquez, F., Arriagada, P., Skouby, S. O., Palacios, S., Tomaszewski, J., Lemieszczuk, B., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173523 · Cited by 63 · see citing works
Self-citationFanchin, R. R. F., Righini, C., Schonäuer, L. M., Olivennes, F. J., Cunha‐Filho, J. S., & Frydman, R. (2001) · Fertility and Sterility · doi:10.1016/s0015-0282(01)02841-2 · Cited by 59 · see citing works
Donnez, J., Arriagada, P., Marciniak, M., & Larrey, D. G. (2018) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2018.1550070 · Cited by 59 · see citing works
Self-citationDistribution of Blood Flow in Myomatous Uteri as Measured by Locally Injected 133XENON
Forssman, L. (1976) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016347609156794 · Cited by 55 · see citing works
The importance of pseudocapsule preservation during hysteroscopic myomectomy
Tinelli, A., Favilli, A., Lasmar, R. B., Mazzon, I., Gerli, S., Xue, X., & Malvası, A. (2019) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2019.09.008 · Cited by 52 · see citing works
Liver injury and ulipristal acetate: an overstated tragedy?
Donnez, J. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.06.044 · Cited by 51 · see citing works
Self-citationNieuwenhuis, L. L., Keizer, A. L., Stoelinga, B., Twisk, J. W. R., Hehenkamp, W. J. K., Brölmann, H., & Huirne, J. A. F. (2017) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.14608 · Cited by 47 · see citing works
Endometrial implantation factors in women with submucous uterine fibroids
Nagi, J. B., MIELL, J. P., Mavrelos, D., Naftalin, J., Lee, C., & Jurkovic, D. (2010) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2010.06.039 · Cited by 46 · see citing works
Rikhraj, K. J. K., Tan, J., Taşkın, Ö., Albert, A., Yong, P. J., & Bedaiwy, M. A. (2019) · Journal of Women s Health · doi:10.1089/jwh.2019.7813 · Cited by 44 · see citing works
Ünlü, C., Çelik, Ö., Çelik, N., & Otlu, B. (2015) · Reproductive Sciences · doi:10.1177/1933719115612929 · Cited by 42 · see citing works
Donnez, J., Courtoy, G. E., Donnez, O., & Dolmans, M. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.04.040 · Cited by 41 · see citing works
Self-citationUterine fibroid management: Today and tomorrow
Dolmans, M., Donnez, J., & Fellah, L. (2019) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.14002 · Cited by 41 · see citing works
Self-citationDonnez, J., Arriagada, P., Donnez, O., & Dolmans, M. (2015) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000229 · Cited by 39 · see citing works
Self-citationUlipristal Acetate Modulates the Expression and Functions of Activin A in Leiomyoma Cells
Ciarmela, P., Carrarelli, P., Islam, M. S., Janjusevic, M., Zupi, E., Tosti, C., Castellucci, M., & Petraglia, F. (2014) · Reproductive Sciences · doi:10.1177/1933719114542019 · Cited by 37 · see citing works
Wang, X., Chen, L., Wang, H., Li, Q., Liu, X., & Qi, H. (2018) · BioMed Research International · doi:10.1155/2018/8924703 · Cited by 37 · see citing works
Lewis, T. D., Malik, M., Britten, J., Parikh, T. P., Cox, J. M., & Catherino, W. H. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.12.026 · Cited by 37 · see citing works
Fibroid management in premenopausal women
Donnez, J., Courtoy, G. E., & Dolmans, M. (2019) · Climacteric · doi:10.1080/13697137.2018.1549216 · Cited by 36 · see citing works
Self-citationChia, C., Huang, S.-C., Chen, S.-S., Kang, J.-Y., Lin, J.-C., Lin, Y.-S., Huang, K.-F., Lee, H.-J., & Zheng, C.-C. (2006) · Taiwanese Journal of Obstetrics and Gynecology · doi:10.1016/s1028-4559(09)60209-6 · Cited by 35 · see citing works
Donnez, J., Donnez, O., & Dolmans, M. (2016) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2016.1248943 · Cited by 33 · see citing works
Self-citationThe current place of medical therapy in uterine fibroid management
Donnez, J., Donnez, O., & Dolmans, M. (2017) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2017.10.008 · Cited by 32 · see citing works
Self-citationCourtoy, G. E., Henriet, P., Marbaix, É., de Codt, M., Luyckx, M., Donnez, J., & Dolmans, M. (2018) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-02295 · Cited by 31 · see citing works
Self-citationEmerging treatment options for uterine fibroids
Donnez, J., Arriagada, P., Donnez, O., & Dolmans, M. (2018) · Expert Opinion on Emerging Drugs · doi:10.1080/14728214.2018.1446943 · Cited by 30 · see citing works
Self-citationSardo, A. D. S., Calagna, G., Carlo, C. D., Guida, M., Perino, A., & Nappi, C. (2015) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.12831 · Cited by 27 · see citing works
Successful Pregnancy after Treatment with Ulipristal Acetate for Uterine Fibroids
Monleón, J., Martínez‐Varea, A., Galliano, D., & Pellicer, A. (2014) · Case Reports in Obstetrics and Gynecology · doi:10.1155/2014/314587 · Cited by 26 · see citing works
Tinelli, A., Kosmas, I. P., Mynbaev, O. A., Favilli, A., Gimbrizis, G., Sparić, R., Pellegrino, M., & Malvası, A. (2018) · BioMed Research International · doi:10.1155/2018/2804830 · Cited by 26 · see citing works
Behbehani, S., Polesello, S., Hasson, J., Silver, J., Son, W., & Dahan, M. H. (2018) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2018.03.005 · Cited by 25 · see citing works
Selective progesterone receptor modulators 2: use in reproductive medicine
Benagiano, G., Bastianelli, C., & Farris, M. (2008) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.9.14.2473 · Cited by 24 · see citing works
Blood Flow in Myomatous Uteri as Measured by Intra‐Arterial 133Xenon
Forssman, L. (1976) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016347609156778 · Cited by 23 · see citing works
The potential of selective progesterone receptor modulators for the treatment of uterine fibroids
Bestel, E., & Donnez, J. (2013) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2014.862495 · Cited by 22 · see citing works
Self-citationFibroids: when should they be removed to improve in vitro fertilization success?
Taylor, H. S. (2018) · Fertility and Sterility · doi:10.1016/j.fertnstert.2018.03.003 · Cited by 22 · see citing works
Chromothripsis in Uterine Leiomyomas
Mehine, M., Kaasinen, E., & Aaltonen, L. A. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1310230 · Cited by 20 · see citing works
Gene expression changes in uterine myomas in response to ulipristal acetate treatment
Courtoy, G. E., Donnez, J., Ambroise, J., Arriagada, P., Luyckx, M., Marbaix, É., & Dolmans, M. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.04.050 · Cited by 20 · see citing works
Self-citationPregnancy Outcomes Following Ulipristal Acetate for Uterine Fibroids: A Systematic Review
Gasperis-Brigante, C. D., Singh, S. S., Vilos, G. A., Kives, S. L., & Murji, A. (2018) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2018.05.020 · Cited by 17 · see citing works
Murad, K. (2016) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2015.11.004 · Cited by 16 · see citing works
Bello, B. D., Marcolongo, P., Ciarmela, P., Sorbi, F., Petraglia, F., Luisi, S. V., & Maellaro, E. (2019) · Fertility and Sterility · doi:10.1016/j.fertnstert.2019.08.007 · Cited by 15 · see citing works
Marqueta, B., Barri, P. N., Coroleu, B., Barri, P. N., & Rodríguez, I. (2015) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000253 · Cited by 13 · see citing works
Luyckx, M., Pirard, C., Fellah, L., Dereume, A., Gzirí, M. M., Debiève, F., & Squifflet, J. P. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.02.049 · Cited by 12 · see citing works
[Uterine contractility and reproduction: new perspectives].
Fanchin, R. R. F., Picone, O., Ayoubi, J. M., Marcadet-Fredet, S., Kadoch, I.-J., & Frydman, R. (2002) · PubMed · Cited by 12 · see citing works
Courtoy, G. E., Donnez, J., Marbaix, É., Barreira, M., Luyckx, M., & Dolmans, M. (2017) · Gynecologic and Obstetric Investigation · doi:10.1159/000480011 · Cited by 10 · see citing works
Self-citationDiamond, M. P., Stewart, E. A., Williams, A. R. W., Carr, B. R., Myers, E. R., Feldman, R., Elger, W. A. G., Mattia‐Goldberg, C., Schwefel, B., & Chwalisż, K. (2019) · Human Reproduction Open · doi:10.1093/hropen/hoz027 · Cited by 10 · see citing works
Stamatellos, I., & Bontis, J. N. (2007) · European Clinics in Obstetrics and Gynaecology · doi:10.1007/s11296-007-0061-1 · Cited by 10 · see citing works
Smulian, J. C., Vintzileos, A. M., Rodis, J. F., & Campbell, W. A. (1996) · Journal of Clinical Ultrasound · doi:10.1002/(sici)1097-0096(199603)24:3 · Cited by 9 · see citing works
Absence of predictable long-term molecular effect of ulipristal acetate (UPA) on the endometrium
Kolańska, K., Varinot, J., Canlorbe, G., Bergeron, C., MEKINIAN, A., Capmas, P., Koskas, M., Daraï, É., Aractingi, S., Bendifallah, S., et al. (2018) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2018.12.013 · Cited by 9 · see citing works
Rewriting the script: time to rethink the indications for myoma surgery
Donnez, J., Donnez, O., & Dolmans, M. (2017) · Fertility and Sterility · doi:10.1016/j.fertnstert.2016.11.027 · Cited by 7 · see citing works
Self-citationSuccessful pregnancy after gigantic uterine fibroids treatment with the help of ulipristal acetate
Тихомиров, А. Л. (2015) · Russian Journal of Human Reproduction · doi:10.17116/repro201521486-88 · Cited by 3 · see citing works
Series of 55 pregnancies following ulipristal acetate treatment of symptomatic uterine fibroids
Costa, A. R., Carvalho, A. P., Rodrigues-Martins, D., Carvalho, M. J., Silva, P. T., Roque, S. C., & da Silva, D. P. (2020) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/2284026520932468 · Cited by 3 · see citing works
Flagged first, then by citations
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Donnez, J., & Dolmans, M.-M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10051085 · Cited by 182 · see citing works
Self-citationConservative management of uterine adenomyosis: medical vs. surgical approach
Stratopoulou, C. A., Donnez, J., & Dolmans, M.-M. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10214878 · Cited by 62 · see citing works
Self-citationInfertility in patients with uterine fibroids: a debate about the hypothetical mechanisms
Don, E. E., Mijatovic, V., & Huirne, J. A. F. (2023) · Human Reproduction · doi:10.1093/humrep/dead194 · Cited by 60 · see citing works
Uterine fibroid–related infertility: mechanisms and management
Donnez, J., Taylor, H. S., Marcellin, L., & Dolmans, M. (2024) · Fertility and Sterility · doi:10.1016/j.fertnstert.2024.02.049 · Cited by 69 · see citing works
Self-citationDonnez, J., & Dolmans, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111342 · Cited by 49 · see citing works
Self-citationEtrusco, A., Laganà, A. S., Chiàntera, V., Vitagliano, A., Cicinelli, E., Mikuš, M., Goldštajn, M. Š., Ferrari, F. G., Uccella, S., Garzon, S., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12154953 · Cited by 45 · see citing works
Favilli, A., Etrusco, A., Chiàntera, V., Laganà, A. S., Cicinelli, E., Gerli, S., & Vitagliano, A. (2023) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.14838 · Cited by 43 · see citing works
The Asian Society of Endometriosis and Adenomyosis guidelines for managing adenomyosis
Harada, T., Taniguchi, F., Guo, S., Choi, Y. M., Biberoglu, K. O., Tsai, S. S., Alborzi, S., Al‐Jefout, M., Chalermchockcharoenkit, A., Sison-Aguilar, A. G., et al. (2023) · Reproductive Medicine and Biology · doi:10.1002/rmb2.12535 · Cited by 44 · see citing works
Dolmans, M., Cacciottola, L., & Donnez, J. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10194389 · Cited by 43 · see citing works
Self-citationDolmans, M., Isaacson, K., Zhang, W., Gordts, S., Munro, M. G., Stewart, E. A., Bourdon, M., Santulli, P., & Donnez, J. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.08.016 · Cited by 39 · see citing works
Self-citationUterine Fibroids and Progestogen Treatment: Lack of Evidence of Its Efficacy: A Review
Donnez, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9123948 · Cited by 38 · see citing works
Self-citationPathogenesis of uterine fibroids: current understanding and future directions
Dolmans, M., Petraglia, F., Catherino, W. H., & Donnez, J. (2024) · Fertility and Sterility · doi:10.1016/j.fertnstert.2024.02.048 · Cited by 37 · see citing works
Self-citationAli, M. K., Raslan, M. A., Ciebiera, M., Zaręba, K. T., & Al-Hendy, A. A. (2021) · Expert Opinion on Drug Safety · doi:10.1080/14740338.2022.1989409 · Cited by 38 · see citing works
Favilli, A., Mazzon, I., Etrusco, A., Dellino, M., Laganà, A. S., Tinelli, A., Chiàntera, V., Cicinelli, E., Gerli, S., & Vitagliano, A. (2023) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.15260 · Cited by 31 · see citing works
Leyland, N. A., Leonardi, M., Murji, A., Singh, S. S., Al-Hendy, A. A., & Bradley, L. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00877-3 · Cited by 28 · see citing works
Han, Y., Yao, R., Zhang, Y., Yang, Z., Luo, H., Wang, X., Du, A., Zhang, Y., & Zhu, Y. (2022) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-022-04828-3 · Cited by 21 · see citing works
Donnez, J., & Dolmans, M.-M. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.07.028 · Cited by 20 · see citing works
Self-citationFactors contributing to persistent disparate outcomes of in vitro fertilization treatment
Aly, J. M., Plowden, T. C., & Christy, A. Y. (2021) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000726 · Cited by 14 · see citing works
Egorova, A., Shtykalova, S., Maretina, M. A., Selutin, A. V., Shved, N. Y., Deviatkin, D., Selkov, S. А., Баранов, В. С., & Kiselev, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031164 · Cited by 14 · see citing works
Large-scale uterine myoma MRI dataset covering all FIGO types with pixel-level annotations
Pan, H., Chen, M., Bai, W., Li, B., Zhao, X., Zhang, M., Zhang, D., Li, Y., Wang, H., Geng, H., et al. (2024) · Scientific Data · doi:10.1038/s41597-024-03170-x · Cited by 14 · see citing works
Myomectomy in infertile women: More harm than good?
Mercorio, A., Corte, L. D., Boccia, D., Palumbo, M., Reppuccia, S., Buonfantino, C., Cuomo, L., Borgo, M., Zitiello, A., Angelis, M. C. D., et al. (2023) · Frontiers in Surgery · doi:10.3389/fsurg.2023.1151901 · Cited by 13 · see citing works
Intramural myomas–related infertility: should the myomas be removed? Not easy to reach a consensus
Donnez, J. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.08.015 · Cited by 13 · see citing works
Self-citationUterine fibroids: the role of signaling pathways in the pathogenesis. A literature review
Yarmolinskaya, M. I., Polenov, N. I., & Kunitsa, V. V. (2020) · Journal of obstetrics and women s diseases · doi:10.17816/jowd695113-124 · Cited by 8 · see citing works
Nonsurgical management of adenomyosis: an overview of current evidence
Lazaridis, A., Grammatis, A. L., Spencer, S., & Hirsch, M. (2022) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0000000000000810 · Cited by 7 · see citing works
Stewart, J. K., Myers, E. R., Petrozza, J. C., Kaufman, C. S., Golzarian, J., Kohi, M. P., Chiang, A., Carlos, R. C., Spies, J. B., Abi‐Jaoudeh, N., et al. (2024) · Journal of Vascular and Interventional Radiology · doi:10.1016/j.jvir.2024.05.014 · Cited by 6 · see citing works
Sun, P., Dong, Y., Yu, Y. F., Xu, H. M., Zhu, L., Zhang, P., & Yan, L. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041401 · Cited by 6 · see citing works
Editorial: Minimally invasive surgery as a mean of improving fertility: What do we know so far?
Naem, A., & Laganà, A. S. (2023) · Frontiers in Surgery · doi:10.3389/fsurg.2023.1203816 · Cited by 6 · see citing works
Possibilities of rehabilitation of patients of reproductive age after myomectomy
Babunashvili, E. L., Shchukina, N. A., Buyanova, S. N., Сергеевна, Б. Т., Владиславовна, Т. Е., Glebov, T. A., Son, D. Y., & Kotsuba, D. R. (2022) · Russian Bulletin of Obstetrician-Gynecologist · doi:10.17116/rosakush20222203193 · Cited by 5 · see citing works
Conservative Treatment of Uterine Myomas: A Network Meta-Analysis of Randomized Controlled Studies
Dominoni, M., Gardella, B., Gritti, A., Pasquali, M. F., & Spinillo, A. (2024) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2024.12.012 · Cited by 4 · see citing works
Ateba, S. B., Mbella, L. F. C. E., Nyobe, J. C. N., Awounfack, C. F., Voutsop, C. J. N., Atsama, P. M., Nana, B. C., Loe, G. E., Dongmo, A. B., & Njamen, D. (2025) · Reproduction and Fertility · doi:10.1530/raf-25-0037 · Cited by 3 · see citing works
Uterine fibroids and infertility: a controverse but concrete link
Sparić, R., Andjić, M., Nejković, L., Stulic, J., Dmitrović, A., Aničić, R., Milovanović, Z., Tomašević, Đ., & Tinelli, A. (2022) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/j.ceog4901018 · Cited by 3 · see citing works
Slotman, D. J., Frijlingh, M., Juffermans, L. J. M., Bartels, L. W., MOONEN, C. T. W., den Bosch, T. V., Boomsma, M. F., & Huirne, J. A. F. (2025) · Insights into Imaging · doi:10.1186/s13244-025-02033-2 · Cited by 2 · see citing works
Application of Balneoclimatology and Physiotherapy in Endometriosis
Wójcik, M., Placek, K. M., Drejza, M. A., Goździewicz, T., Pisarska-Krawczyk, M., Luwański, D., Plagens-Rotman, K., Kędzia, W., & Jarząbek‐Bielecka, G. (2023) · Acta Balneologica · doi:10.36740/abal202306112 · Cited by 2 · see citing works
Moreno, J. L. G., & López, S. S. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.98402 · Cited by 2 · see citing works
5 Infertility and assisted reproduction
Maclean, A. (2004) · Routledge eBooks · doi:10.4324/9781843148913-19 · Cited by 1 · see citing works
Intramural Fibroids Greater than 4 cm in Diameter Should Be Removed to Aid Fertility
Donnez, J., & Dolmans, M. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108986373.045
Self-citationElias, R. T. (2023) · Contemporary Endocrinology · doi:10.1007/978-3-031-19443-6_16
Tratamiento médico de los miomas uterinos. Del presente al futuro
Goitia, M., Andres, M., Aquesolo, L., Azkuenaga, A., Cearsolo, A., Bueis, J. D. L., Diaz, T., Diez, S., Zilloniz, N. M., Millán, L. E. S., et al. (2023) · Clínica e Investigación en Ginecología y Obstetricia · doi:10.1016/j.gine.2023.100845
Terapias emergentes en el tratamiento médico de los miomas uterinos
Goitia, M., & Estadella, J. (2023) · Medicina Clínica · doi:10.1016/j.medcli.2023.06.034
Don, E. E. (2023) · doi:10.5463/thesis.409
Myomectomy for Infertility: Does it Do More Damage Than Good?
Solanki, S. B. (2023) · Journal of Gynecology and Womens Health · doi:10.19080/jgwh.2023.26.556177
Huseynova, Z. S. (2025) · Yakut Medical Journal · doi:10.25789/ymj.2025.89.05
МЕТОДЫ ЛЕЧЕНИЯ МИОМ МАТКИ НА СТАДИИ ПЛАНИРОВАНИЯ И ВО ВРЕМЯ БЕРЕМЕННОСТИ
Абрамян, С. О. (2025) · MEDICINE SCIENCE AND EDUCATION · doi:10.56936/18291775-2025.39-17
He, L., Li, W., & Lv, Y. (2025) · Clinical Pharmacology in Drug Development · doi:10.1002/cpdd.1567
Impact of leiomyoma on fertility
Зиганшин, А. М., Erushenkova, S. V., Ринатовна, Я. А., & Дикке, Г. Б. (2025) · Journal of obstetrics and women s diseases · doi:10.17816/jowd675765
Shin, I., Park, J. Y., Chung, Y., Song, J., Lee, S., & Kim, M. K. (2025) · Clinical and Experimental Obstetrics & Gynecology · doi:10.31083/ceog39094
Uterine fibroids and infertility
Vannuccini, S., Manzi, V., & Petraglia, F. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00312-5
Оточина, Н., Тюрина, Н., & Shubin, D. Y. (2026) · Cifra LLC Journals · doi:10.60797/irj.2026.166.82
Daniilidis, A., Grigoriadis, G., Nisolle, M., Castelo‐Branco, C., Angioni, S. L., Kalkan, Ü., Cela, V., Mikulášek, L., & Pados, G. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15134986
- Authors
- Donnez, J., & Dolmans, M.-M.
- Affiliations
- UCLouvain (BE)
- Cliniques Universitaires Saint-Luc (BE)
- Corresponding author
- Donnez, Jacques
- Venue
- Reproductive BioMedicine Online
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 41
- Issue
- 3
- Pages
- 431-442
- ISSN
- 1472-6483 (ISSN-L)
- OpenAlex
- W3034352648
- Cited by
- 50
- References
- 109
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 15 · 2022: 6 · 2021: 10 · 2020: 3
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Reproductive BioMedicine Online (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion, other-oa)
- Funders
- Fondation contre le Cancer
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Uterine Myomas and Treatments
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- intramural uterine fibroids, ulipristal acetate, GnRH antagonist, selective progesterone receptor modulators, endometrial receptivity, HOXA10, uterine contractility, treatment algorithm
- MeSH terms
- Female, Hormone Antagonists, Humans, Infertility, Female, Leiomyoma, Norpregnadienes, Uterine Neoplasms
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