The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Nitrite: A physiological store of nitric oxide and modulator of mitochondrial function
Open accessAbstract
Nitrite, long considered a biologically inert metabolite of nitric oxide (NO) oxidation, is now accepted as a physiological storage pool of NO that can be reduced to bioactive NO in hypoxic conditions to mediate a spectrum of physiological responses in blood and tissue. This graphical review will provide a broad overview of the role of nitrite in physiology, focusing on its formation and reduction to NO as well as its regulation of the mitochondrion- an emerging subcellular target for its biological actions in tissues.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Emerging evidence suggests that NO deficiency is associated with impaired mitochondrial function”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [167]
In the citing paper
“and that restoration of NO bioavailability induces mitochondrial biogenesis (127, 135, 167, 168)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [167]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739 · cited 2×
“Nitrite reduction by these enzymes with differing oxygen affinities, tissue distribution and rates of reduction, ensures NO generation and nitrosative modification of target proteins over a wide range of physiological hypoxia in the cell [1].”
BackgroundNitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation
Cosby, K., Partovi, K. S., Crawford, J. H., Patel, R. P., Reiter, C. D., Martyr, S., Yang, B. K., Waclawiw, M. A., Zalos, G., Xu, X., et al. (2003) · Nature Medicine · doi:10.1038/nm954 · Cited by 1,807
Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury
Murphy, E., & Steenbergen, C. (2008) · Physiological Reviews · doi:10.1152/physrev.00024.2007 · Cited by 1,504 · cited 1×
“respiratory chain results in excessive reactive oxygen species generation at complexes I and III and oxidation of critical proteins leading to opening of the mitochondrial permeability transition pore (PTP) as well as release of cytochrome c to initiate apoptosis [30,31].”
BackgroundCleeter, M. W. J., Cooper, J. M., Darley-Usmar, V. M., Moncada, S., & Schapira, A. H. V. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)00424-2 · Cited by 1,241
Dietary Inorganic Nitrate Improves Mitochondrial Efficiency in Humans
Larsen, F. J., Schiffer, T. A., Borniquel, S., Sahlin, K., Ekblom, B., Lundberg, J. O., & Weitzberg, E. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.01.004 · Cited by 689 · cited 3×
“Further, the authors reported a NO3 -induced decrease in the expression of uncoupling protein 3 (UCP-3) and the adenine nucleotide translocase (ANT), two proteins which facilitate proton leak [25].”
BackgroundCytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver
Duranski, M. R., Greer, J. J. M., Dejam, A., Jaganmohan, S., Hogg, N., Langston, W., Patel, R. P., Yet, S.-F., Wang, X., Kevil, C. G., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22493 · Cited by 674
Oxidation of nitrogen-oxides by bound dioxygen in hemoproteins
Doyle, M. P., & Hoekstra, J. W. (1981) · Journal of Inorganic Biochemistry · doi:10.1016/s0162-0134(00)80291-3 · Cited by 643
Effects of dietary nitrate on oxygen cost during exercise
Larsen, F. J., Weitzberg, E., Lundberg, J. O., & Ekblom, B. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01713.x · Cited by 637 · cited 2×
“This leads to downstream signaling to induce a wide spectrum of biological responses including hypoxic vasodilation [8], stimulation of angiogenesis [23], modulation of glucose metabolism [24], augmentation of exercise efficiency [20], regulation of mitochondrial function [9,25,26] and tolerance to I/R [22,27–29] (Fig.”
BackgroundWebb, A., Bond, R., McLean, P., Uppal, R., Benjamin, N., & Ahluwalia, A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402927101 · Cited by 608
Shiva, S., Huang, Z., Grubina, R., Sun, J., Ringwood, L. A., MacArthur, P. H., Xu, X., Murphy, E., Darley-Usmar, V. M., & Gladwin, M. T. (2007) · Circulation Research · doi:10.1161/01.res.0000260171.52224.6b · Cited by 599
Self-citation
Cited by
Sorted by citations
The role of the nitric oxide pathway in brain injury and its treatment — From bench to bedside
Garry, P. S., Ezra, M., Rowland, M. J., Westbrook, J., & Pattinson, K. T. S. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2014.10.017 · Cited by 380
“NOdonorsmay be neuroprotective by preventingNOdepletion, helping to normalize capillary blood flow and improve oxygen delivery to the tissue (Shiva, 2013).”
BackgroundLiquid Chromatography Analysis of Common Nutritional Components, in Feed and Food
Cortés-Herrera, C., Artavia, G., Leiva, A., & Granados-Chinchilla, F. (2018) · Foods · doi:10.3390/foods8010001 · Cited by 275
Kumar, M., Sahu, S. K., Kumar, R., Subuddhi, A., Maji, R. K., Jana, K., Gupta, P., Raffetseder, J., Lerm, M., Ghosh, Z., et al. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2015.01.007 · Cited by 259
“Nitrite also serves as a physiological storage pool of NO that can be reduced to bioactive NO under hypoxic conditions (Shiva, 2013).”
BackgroundRemote ischaemic conditioning—a new paradigm of self-protection in the brain
Hess, D. C., Blauenfeldt, R. A., Andersen, G., Hougaard, K. D., Hoda, M. N., Ding, Y., & Ji, X. (2015) · Nature Reviews Neurology · doi:10.1038/nrneurol.2015.223 · Cited by 234
Antioxidative nanomaterials and biomedical applications
Liu, Y., & Shi, J. (2019) · Nano Today · doi:10.1016/j.nantod.2019.05.008 · Cited by 174
Metadata
- Authors
- Shiva, S.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Shiva, Sruti
- ORCID
- Shiva, Sruti
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2013
- Volume
- 1
- Issue
- 1
- Pages
- 40-44
- ISSN
- 2213-2317 (ISSN-L)
- PMC
- PMC3661298
- OpenAlex
- W2059688150
- Cited by
- 207
- References
- 38
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 18 · 2023: 7 · 2022: 20 · 2021: 18 · 2020: 16 · 2019: 14 · 2018: 18 · 2017: 17 · 2016: 21 · 2015: 20 · 2014: 8 · 2013: 3
- FWCI
- 12.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Redox Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- NIH (1R01HL096973)
- AHA (09SDG2150066)
- Institution of Transfusion Medicine
- Hemophilia Center of Western Pennsylvania
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- nitrite, nitric oxide, nitric oxide storage, hypoxia, mitochondrial function, nitrite reduction, nitric oxide signaling, redox regulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
