Cited by 120Alzheimer's disease research and treatmentsBiochemical Acid Research StudiesAntioxidant Activity and Oxidative Stress

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Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

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Hardas, Sarita S., Sultana, Rukhsana, Clark, Amy M., Beckett, Tina L., Szweda, Luke I., Murphy, M. Paul, Butterfield, D. Allan·2013·Redox Biology

DOI 10.1016/j.redox.2013.01.002PMC PMC3757677

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Abstract

Alzheimer disease (AD) is an age-related neurodegenerative disease characterized by the presence of three pathological hallmarks: synapse loss, extracellular senile plaques (SP) and intracellular neurofibrillary tangles (NFTs). The major component of SP is amyloid β-peptide (Aβ), which has been shown to induce oxidative stress. The AD brain shows increased levels of lipid peroxidation products, including 4-hydroxy-2-nonenal (HNE). HNE can react covalently with Cys, His, or Lys residues on proteins, altering structure and function of the latter. In the present study we measured the levels of the HNE-modified lipoic acid in brain of subjects with AD and age-matched controls. Lipoic acid is a key co-factor for a number of proteins including pyruvate dehydrogenase and α-ketoglutarate dehydrogenase, key complexes for cellular energetics. We observed a significant decrease in the levels of HNE-lipoic acid in the AD brain compared to that of age-matched controls. To investigate this phenomenon further, the levels and activity of lipoamide dehydrogenase (LADH) were measured in AD and control brains. Additionally, LADH activities were measured after in-vitro HNE-treatment to mice brains. Both LADH levels and activities were found to be significantly reduced in AD brain compared to age-matched control. HNE-treatment also reduced the LADH activity in mice brain. These data are consistent with a two-hit hypothesis of AD: oxidative stress leads to lipid peroxidation that, in turn, causes oxidative dysfunction of key energy-related complexes in mitochondria, triggering neurodegeneration. This study is consonant with the notion that lipoic acid supplementation could be a potential treatment for the observed loss of cellular energetics in AD and potentiate the antioxidant defense system to prevent or delay the oxidative stress in and progression of this devastating dementing disorder.

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Authors: Hardas, S. S., Sultana, R., Clark, A. M., Beckett, T. L., Szweda, L. I., Murphy, M. P., & Butterfield, D. A.
Affiliations: University of Kentucky (US)
Case Western Reserve University (US)
Corresponding author: Butterfield, D. Allan
ORCID: Szweda, Luke I.
Butterfield, D. Allan
Venue: Redox Biology
Publisher: Elsevier BV
Published: 2013
Volume: 1
Issue: 1
Pages: 80-85
ISSN: 2213-2317 (ISSN-L)
DOI: 10.1016/j.redox.2013.01.002
PMC: PMC3757677
OpenAlex: W2039562082
Cited by: 120
References: 74
Citations by year: 2026: 1 · 2025: 2 · 2024: 9 · 2023: 6 · 2022: 5 · 2021: 16 · 2020: 13 · 2019: 9 · 2018: 7 · 2017: 10 · 2016: 12 · 2015: 11 · 2014: 18 · 2013: 1
FWCI: 9.75
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/3.0/ (vor, 196 d)
Locations: Redox Biology (publishedVersion, cc-by-nc-nd)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
UKnowledge (University of Kentucky) (submittedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders: NIH (AG-05119)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords: Alzheimer's disease, alpha-lipoic acid, 4-hydroxynonenal, lipid peroxidation, oxidative stress, lipoamide dehydrogenase, protein modification, mitochondrial bioenergetics, pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, two-hit hypothesis, neurodegeneration
MeSH terms: Aldehydes, Alzheimer Disease, Animals, Brain, Humans, Dihydrolipoamide Dehydrogenase, Thioctic Acid, Male, Mice, Inbred C57BL, Case-Control Studies, Oxidative Stress, Mice

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Oxidative modification of lipoic acid by HNE in Alzheimer disease brain

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