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Nitrosopersulfide (SSNO−) accounts for sustained NO bioactivity of S-nitrosothiols following reaction with sulfide
Open accessAbstract
Sulfide salts are known to promote the release of nitric oxide (NO) from S-nitrosothiols and potentiate their vasorelaxant activity, but much of the cross-talk between hydrogen sulfide and NO is believed to occur via functional interactions of cell regulatory elements such as phosphodiesterases. Using RFL-6 cells as an NO reporter system we sought to investigate whether sulfide can also modulate nitrosothiol-mediated soluble guanylyl cyclase (sGC) activation following direct chemical interaction. We find a U-shaped dose response relationship where low sulfide concentrations attenuate sGC stimulation by S-nitrosopenicillamine (SNAP) and cyclic GMP levels are restored at equimolar ratios. Similar results are observed when intracellular sulfide levels are raised by pre-incubation with the sulfide donor, GYY4137. The outcome of direct sulfide/nitrosothiol interactions also critically depends on molar reactant ratios and is accompanied by oxygen consumption. With sulfide in excess, a 'yellow compound' accumulates that is indistinguishable from the product of solid-phase transnitrosation of either hydrosulfide or hydrodisulfide and assigned to be nitrosopersulfide (perthionitrite, SSNO(-); λ max 412 nm in aqueous buffers, pH 7.4; 448 nm in DMF). Time-resolved chemiluminescence and UV-visible spectroscopy analyses suggest that its generation is preceded by formation of the short-lived NO-donor, thionitrite (SNO(-)). In contrast to the latter, SSNO(-) is rather stable at physiological pH and generates both NO and polysulfides on decomposition, resulting in sustained potentiation of SNAP-induced sGC stimulation. Thus, sulfide reacts with nitrosothiols to form multiple bioactive products; SSNO(-) rather than SNO(-) may account for some of the longer-lived effects of nitrosothiols and contribute to sulfide and NO signaling.
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In the citing paper
“The resulting nitroso compound, nitrosopersulfide (perthionitrite; SSNO -) appears, from our recent work [19] and that of Seel et al. [58,59], to be considerably more stable than HSNO -even in the presence of high concentrations of thiols -and, therefore, a potentially better signaling molecule.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“The resulting nitroso compound, nitrosopersulfide (perthionitrite; SSNO -) appears, from our recent work [19] and that of Seel et al. [58,59], to be considerably more stable than HSNO -even in the presence of high concentrations of thiols -and, therefore, a potentially better signaling molecule.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“Indeed, we found that SSNO -was able to release NO and induce sGC-dependent cGMP production in cells [19], but its detection in cells/tissues necessitates development of specific and sufficiently sensitive analytical methods, a task that has not yet been accomplished.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“Based on Seel's earlier findings [58,68,69] we assign this product to be nitrosopersulfide, SSNO - [19].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“Taken together, nitrite reacts with S8 and, seemingly less efficiently, with polysulfides in non-aqueous polar solvents leading to the formation of similar products as observed previously in the reaction of NO with sulfide [69], and nitrosothiols with thiols [70], and with sulfide [19,71] including SSNO -.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“the latter have been shown to rapidly react with sulfide in vitro, leading to formation of S/N-hybrid species including thionitrite (SNO -) and nitrosopersulfide (SSNO -).”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“Evidence of pharmacological activity of SSNO -leading to sGC activation with concomitant cGMP formation in cells was presented by us recently [19].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“Contrary to nitrosothiols, SSNO -like polysulfides is unstable under strong acidic conditions, leading to rapid decomposition and excision of S8 [19].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“SSNO -is a colored species containing a sulfane sulfur and a nitrosonium (NO + ) moiety attached to opposite ends of a sulfur atom.”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“It formally belongs to the group of polysulfides (Sx 2-);”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“however, contrary to polysulfides and other nitrosothiols, it is stable in the presence of millimolar concentrations of reduced thiols, including cysteine and glutathione (even dithiotheritol, DTT) [19].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“If sulfide is in excess over the nitrosothiol (which are found in tissues typically at nM concentrations), SSNO -is likely to accumulate and may more easily transport and release NO than GSNO or S-nitrosoalbumin [19].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
In the citing paper
“SSNO -should be sufficiently stable in the reducing environment of the cell; at the same time, it is a better NO releaser than the parent nitrosothiol [19].”
From On the chemical biology of the nitrite/sulfide interaction (2015) · cites this paper as [19]
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Metadata
- Authors
- Cortese-Krott, M. M., Fernandez, B. O., Santos, J. L. T., Mergia, E., Grman, M., Nagy, P., Kelm, M., Butler, A., & Feelisch, M.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Southampton General Hospital (GB)
- Ruhr University Bochum (DE)
- Slovak Academy of Sciences (SK)
- National Institute of Oncology (HU)
- University of St Andrews (GB)
- Corresponding author
- Feelisch, Martin
- ORCID
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2014
- Volume
- 2
- Pages
- 234-244
- ISSN
- 2213-2317 (ISSN-L)
- PMC
- PMC3909780
- OpenAlex
- W2037151440
- Cited by
- 153
- References
- 64
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 5 · 2020: 17 · 2019: 11 · 2018: 12 · 2017: 22 · 2016: 20 · 2015: 14 · 2014: 14
- FWCI
- 10.37
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Redox Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (acceptedVersion)
- University of Debrecen Electronic Archive (University of Debrecen) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- St Andrews Research Repository (St Andrews Research Repository) (submittedVersion, cc-by)
- Funders
- European Network on Gasotransmitters
- FP7 Marie Curie International Reintegration program (PIRG08-GA-2010-277006, to PN)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- S-nitrosothiols, sulfide, nitric oxide, hydrogen sulfide signaling, transnitrosation, thionitrites, GYY4137, cyclic GMP, polysulfides, oxygen consumption
- MeSH terms
- Soluble Guanylyl Cyclase, Animals, Cell Line, Cyclic GMP, Guanylate Cyclase, Morpholines, Nitric Oxide, Nitroso Compounds, Organothiophosphorus Compounds, Oxygen Consumption, Sulfides, Receptors, Cytoplasmic and Nuclear, Nitric Oxide Donors, S-Nitrosothiols, Rats
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