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Cited by 1,546Redox biology and oxidative stressCalcium signaling and nucleotide metabolismIon Channels and Receptors

The DOI matches its Crossref record; 175 of the 180 references it cites were found in a registry or an index.

Calcium and ROS: A mutual interplay

Open access
Görlach, Agnes, Bertram, Katharina, Hudecova, Sona, Krizanova, Olga·2015·Redox Biology
DOI 10.1016/j.redox.2015.08.010PMC PMC4556774
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Abstract

Calcium is an important second messenger involved in intra- and extracellular signaling cascades and plays an essential role in cell life and death decisions. The Ca(2+) signaling network works in many different ways to regulate cellular processes that function over a wide dynamic range due to the action of buffers, pumps and exchangers on the plasma membrane as well as in internal stores. Calcium signaling pathways interact with other cellular signaling systems such as reactive oxygen species (ROS). Although initially considered to be potentially detrimental byproducts of aerobic metabolism, it is now clear that ROS generated in sub-toxic levels by different intracellular systems act as signaling molecules involved in various cellular processes including growth and cell death. Increasing evidence suggests a mutual interplay between calcium and ROS signaling systems which seems to have important implications for fine tuning cellular signaling networks. However, dysfunction in either of the systems might affect the other system thus potentiating harmful effects which might contribute to the pathogenesis of various disorders.

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Metadata

Authors
Görlach, A., Bertram, K., Hudecova, S., & Krizanova, O.
Affiliations
  • German Centre for Cardiovascular Research (DE)
  • Deutsches Herzzentrum München (DE)
Corresponding author
Görlach, Agnes
ORCID
Görlach, Agnes
Venue
Redox Biology
Publisher
Elsevier BV
Published
2015-12
Volume
6
Pages
260-271
ISSN
2213-2317 (ISSN-L)
DOI
10.1016/j.redox.2015.08.010
PMC
PMC4556774
OpenAlex
W1165140024
Cited by
1,546
References
180
Citations by year
2026: 128 · 2025: 188 · 2024: 195 · 2023: 184 · 2022: 177 · 2021: 179 · 2020: 141 · 2019: 133 · 2018: 115 · 2017: 72 · 2016: 30 · 2015: 3
FWCI
7.11
Type
journal article
Language
en
Open access
Licence
Locations
  • Redox Biology (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • mediaTUM (Technical University of Munich) (submittedVersion)
Funders
  • Bundesministerium für Bildung und Forschung (SAV 2/0074)
  • Deutsches Zentrum für Herz-Kreislaufforschung
  • Deutsche Forschungsgemeinschaft (DFG-GO709/4-5)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
  • Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
Keywords
calcium signaling, reactive oxygen species, second messengers, cell death, cell signaling networks, redox signaling, intracellular calcium stores
MeSH terms
Animals, Calcium, Cell Membrane, Endoplasmic Reticulum, Eukaryotic Cells, Gene Expression Regulation, Humans, Mitochondria, Calcium Channels, Cell Death, Reactive Oxygen Species, Oxidative Stress, NADPH Oxidases, Calcium Signaling, Plasma Membrane Calcium-Transporting ATPases

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