The DOI matches its Crossref record; 267 of the 267 references it cites were found in a registry or an index.
Interplay between oxidant species and energy metabolism
Open accessAbstract
It has long been recognized that energy metabolism is linked to the production of reactive oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by redox reactions. This interplay between energy metabolism and ROS becomes most apparent during the aging process and in the onset and progression of many age-related diseases (i.e. diabetes, metabolic syndrome, atherosclerosis, neurodegenerative diseases). As such, the capacity to identify metabolic pathways involved in ROS formation, as well as specific targets and oxidative modifications is crucial to our understanding of the molecular basis of age-related diseases and for the design of novel therapeutic strategies. Herein we review oxidant formation associated with the cell's energetic metabolism, key antioxidants involved in ROS detoxification, and the principal targets of oxidant species in metabolic routes and discuss their relevance in cell signaling and age-related diseases.
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Cites
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Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
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“As such, the capacity to identify metabolic pathways involved in ROS formation, as well as specific targets and oxidative modifications is crucial to our understanding of the molecular basis of age-related diseases and for the design of novel therapeutic strategies.”
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ROS: Basic Concepts, Sources, Cellular Signaling, and its Implications in Aging Pathways
de Almeida, A. J. P. O., de Oliveira, J. C. P. L., da Silva Pontes, L. V., de Souza Júnior, J. F., Gonçalves, T. A. F., Dantas, S. H., de Almeida Feitosa, M. S., Silva, A. O., & de Medeiros, I. A. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/1225578 · Cited by 474
Diverse Roles of Mitochondria in Immune Responses: Novel Insights Into Immuno-Metabolism
Angajala, A., Lim, S., Phillips, J. B., Kim, J.-H., Yates, C., You, Z., & Tan, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01605 · Cited by 455
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
Arra, M., Swarnkar, G., Ke, K., Otero, J. E., Ying, J., Duan, X., Maruyama, T., Rai, M. F., O’Keefe, R. J., Mbalaviele, G., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-17242-0 · Cited by 412
Role of Oxidative Stress in Liver Disorders
Conde de la Rosa, L., Goicoechea, L., Torres, S., Garcia-Ruiz, C., & Fernandez-Checa, J. C. (2022) · Livers · doi:10.3390/livers2040023 · Cited by 107
Cui, J., Li, Z., Zhuang, S., Qi, S., Li, L., Zhou, J., Zhang, W., & Zhao, Y. (2018) · Cell Stress and Chaperones · doi:10.1007/s12192-017-0841-6 · Cited by 65
Metadata
- Authors
- Quijano, C., Trujillo, M., Castro, L., & Trostchansky, A.
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2016-08
- Volume
- 8
- Pages
- 28-42
- ISSN
- 2213-2317 (ISSN-L)
- OpenAlex
- W2183107372
- Cited by
- 304
- References
- 267
- FWCI
- 4.63
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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