The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis
Open accessAbstract
The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear, and this lack of clarity is detrimental to efforts to identify therapeutic targets. Here we show that chondrocytes under inflammatory conditions undergo a metabolic shift that is regulated by NF-κB activation, leading to reprogramming of cell metabolism towards glycolysis and lactate dehydrogenase A (LDHA). Inflammation and metabolism can reciprocally modulate each other to regulate cartilage degradation. LDHA binds to NADH and promotes reactive oxygen species (ROS) to induce catabolic changes through stabilization of IκB-ζ, a critical pro-inflammatory mediator in chondrocytes. IκB-ζ is regulated bi-modally at the stages of transcription and protein degradation. Overall, this work highlights the function of NF-κB activity in the OA joint as well as a ROS promoting function for LDHA and identifies LDHA as a potential therapeutic target for OA treatment.
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Cites
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Crosstalk between bone and brain in Alzheimer's disease: Mechanisms, applications, and perspectives
Liu, Z., Liu, M., Xiong, Y., Wang, Y., & Bu, X. (2024) · Alzheimer's & Dementia · doi:10.1002/alz.13864 · Cited by 39
Bi, J., Zhang, L., Zhang, P., Xu, S., Liu, Y., Zhang, X., Qiu, X., Bi, Y., Yan, F., Wei, H., et al. (2024) · Biomaterials Research · doi:10.34133/bmr.0075 · Cited by 12
Metadata
- Authors
- Arra, M., Swarnkar, G., Ke, K., Otero, J. E., Ying, J., Duan, X., Maruyama, T., Rai, M. F., O’Keefe, R. J., Mbalaviele, G., Shen, J., & Abu-Amer, Y.
- Venue
- Nature Communications
- Published
- 2020-07-09
- Volume
- 11
- Issue
- 1
- Pages
- 3427-3427
- ISSN
- 2041-1723 (ISSN-L)
- OpenAlex
- W3041516084
- Cited by
- 412
- References
- 69
- FWCI
- 24.15
- Type
- journal article
- Language
- en
- Open access
- gold
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- Arra, M., Swarnkar, G., Ke, K., Otero, J. E., Ying, J., Duan, X., Maruyama, T., Rai, M. F., O’Keefe, R. J., Mbalaviele, G., Shen, J., & Abu-Amer, Y. (2020). LDHA-mediated ROS generation in chondrocytes is a potential therapeutic target for osteoarthritis. Nature Communications. https://doi.org/10.1038/s41467-020-17242-0
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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