Homocysteine causes dysfunction of chondrocytes and oxidative stress through repression of SIRT1/AMPK pathway: A possible link between hyperhomocysteinemia and osteoarthritis
Open accessAbstract
Emerging evidence has indicated that the perturbed expression of homocysteine (Hcy) may induce mitochondrial dysfunction and disturb bone metabolism. Sirtuin 1 (SIRT1) and AMP-activated protein kinase (AMPK) are two critical sensors that regulate mitochondrial biogenesis and have been recognized as therapeutic targets in osteoarthritis (OA). This study was designed to test whether Hcy caused pro-osteoarthritic changes through modulation of SIRT1 and AMPK. Our results showed that administration of Hcy reduced the SIRT1/AMPK/PGC-1α signaling in chondrocytes, leading to mitochondrial dysfunction as a result of increased oxidative stress and apoptosis. Moreover, we demonstrated that the expression of NF-κB, COX-2, IL-8, and MMP-13 were elevated subsequent to inhibition of SIRT1/AMPK/PGC-1α/PPAR-γ pathway by homocysteine, thereby causing detrimental effects on chondrocytes. In the animal model of diet-induced hyperhomocysteinemia (HHcy), we observed the similar findings that SIRT1/PGC-1α/PPAR-γ cascades were downregulated with elevated MMP-13 and COX-2. Taken together, data from the current study revealed that the reduced SIRT1 by Hcy may contribute to degradative cartilage process, which provided insight into the etiology of OA.
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SIRT1 activation is an effective approach to manage hyperhomocysteinemia-induced oxidative stress.
“Previous reports have suggested that SIRT1 activation is an effective approach to manage HHcy‐induced oxidative stress,33, 34”
From Picroside <scp>II</scp> attenuates hyperhomocysteinemia‐induced endothelial injury by reducing inflammation, oxidative stress and cell apoptosis (2019) · cites this paper as [33]
The Results section, “Homocysteine-induced oxidative stress is reversed by activation of SIRT1/AMPK/PGC-1α signaling,” reports that SIRT1 overexpression reduced the oxidative-stress effects of homocysteine in human chondrocytes. This supports SIRT1 activation as a potential approach, but the cell experiments do not establish that it effectively manages hyperhomocysteinemia-induced oxidative stress in patients. (LLM, conf=0.84)
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Cites
The Role of Mitochondria in Apoptosis
Wang, C., & Youle, R. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134850 · Cited by 1,987 · see citing works
PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
Cantó, C., & Auwerx, J. (2009) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e328328d0a4 · Cited by 1,624 · see citing works
Sirt1 protects against high-fat diet-induced metabolic damage
Pfluger, P. T., Herranz, D., Velasco-Miguel, S., Serrano, M., & Tschöp, M. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802917105 · Cited by 928 · see citing works
Monitoring of relative mitochondrial membrane potential in living cells by fluorescence microscopy.
Johnson, L. V., Walsh, M. L., Bockus, B. J., & Chen, L. B. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.88.3.526 · Cited by 914 · see citing works
Homocysteine Levels and the Risk of Osteoporotic Fracture
van Meurs, J. B. J., Dhonukshe-Rutten, R. A. M., Pluijm, S. M. F., van der Klift, M., de Jonge, R., Lindemans, J. W., de Groot, C. P. G. M., Albert Hofman, D., Witteman, J. C. M., van Leeuwen, J. P. T. M., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032546 · Cited by 740 · see citing works
The role of mitochondria in osteoarthritis
Blanco, F. J., Rego‐Pérez, I., & Ruíz‐Romero, C. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.213 · Cited by 549 · see citing works
Yudoh, K., van Trieu, N., Nakamura, H., Masuko, K., Kato, T., & Nishioka, K. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1499 · Cited by 397 · see citing works
Tanno, M., Kuno, A., Yano, T., Miura, T., Hisahara, S., Ishikawa, S., Shimamoto, K., & Horio, Y. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.090266 · Cited by 358 · see citing works
Wang, Y., Zhao, X., Lotz, M., Terkeltaub, R. A., & Liu‐Bryan, R. (2015) · Arthritis & Rheumatology · doi:10.1002/art.39182 · Cited by 303 · see citing works
Apoptosis in normal and osteoarthritic human articular cartilage
Héraud, F., Héraud, A., & Harmand, M. F. (2000) · Annals of the Rheumatic Diseases · doi:10.1136/ard.59.12.959 · Cited by 278 · see citing works
Mitochondrial respiratory activity is altered in osteoarthritic human articular chondrocytes
Maneiro, E., Martín, M. A., de Andrés, M. C., López-Armada, M. J., FERNÁNDEZ-SUEIRO, J. L., del Hoyo, P., Galdo, F., Arenas, J., & Blanco, F. J. (2003) · Arthritis & Rheumatism · doi:10.1002/art.10837 · Cited by 263 · see citing works
Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease
Scott, J. L., Gabrielides, C., Davidson, R. K., Swingler, T. E., Clark, I. M., Wallis, G. A., Boot-Handford, R., Kirkwood, T. B. L., Talyor, R. W., & Young, D. A. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.119966 · Cited by 258 · see citing works
Carlo, M. D., & Loeser, R. F. (2003) · Arthritis & Rheumatism · doi:10.1002/art.11338 · Cited by 254 · see citing works
Chondrocyte death by apoptosis is associated with cartilage matrix degradation
Thomas, C. M., Fuller, C. J., Whittles, C. E., & Sharif, M. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2006.06.012 · Cited by 248 · see citing works
SIRT1 regulation of apoptosis of human chondrocytes
Takayama, K., Ishida, K., Matsushita, T., Fujita, N., Hayashi, S., Sasaki, K., Tei, K., Kubo, S., Matsumoto, T., Fujioka, H., et al. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24864 · Cited by 206 · see citing works
Koh, J., Lee, Y., Kim, Y. S., Kim, D. J., Kim, H., Park, J., Lee, K., & Kim, G. S. (2006) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.060406 · Cited by 202 · see citing works
Mitochondrial dysfunction in osteoarthritis.
Blanco, F., López-Armada, M. J., & Maneiro, E. (2004) · Mitochondrion (Amsterdam. Print) · doi:10.1016/j.mito.2004.07.022 · Cited by 190 · see citing works
Sharif, M., Whitehouse, A., Sharman, P., Perry, M., & Adams, M. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20020 · Cited by 173 · see citing works
Gavriilidis, C., Miwa, S., von Zglinicki, T., Taylor, R. W., & Young, D. A. (2012) · Arthritis & Rheumatism · doi:10.1002/art.37782 · Cited by 160 · see citing works
Homocysteine Imbalance: a Pathological Metabolic Marker
Schalinske, K. L., & Smazal, A. L. (2012) · Advances in Nutrition · doi:10.3945/an.112.002758 · Cited by 157 · see citing works
Fujita, N., Matsushita, T., Ishida, K., Kubo, S., Matsumoto, T., Takayama, K., Kurosaka, M., & Kuroda, R. (2010) · Journal of Orthopaedic Research® · doi:10.1002/jor.21284 · Cited by 145 · see citing works
Gagarina, V., Gabay, O., Dvir‐Ginzberg, M., Lee, E. J., Brady, J. K., Quon, M. J., & Hall, D. J. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27369 · Cited by 137 · see citing works
SIRT1, a class III histone deacetylase, regulates TNF-α-induced inflammation in human chondrocytes
Moon, M.-H., Jeong, J., Lee, Y.-J., Seol, J., Jackson, C., & Park, S.-Y. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.11.017 · Cited by 128 · see citing works
Matsushita, T., Sasaki, H., Takayama, K., Ishida, K., Matsumoto, T., Kubo, S., Matsuzaki, T., Nishida, K., Kurosaka, M., & Kuroda, R. (2012) · Journal of Orthopaedic Research® · doi:10.1002/jor.22268 · Cited by 128 · see citing works
The role of homocysteine in bone remodeling
Vacek, T. P., Kalani, A., Voor, M. J., Tyagi, S. C., & Tyagi, N. (2013) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2012-0605 · Cited by 118 · see citing works
Inflammation and intracellular metabolism: new targets in OA
Liu‐Bryan, R. (2015) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.12.016 · Cited by 113 · see citing works
Homocysteine level and risk of fracture: A meta-analysis and systematic review
Yang, J., Hu, X., Qiang, Z., Cao, H., Wang, J., & Liu, B. (2012) · Bone · doi:10.1016/j.bone.2012.05.024 · Cited by 112 · see citing works
Herrmann, M., Tami, A., Wildemann, B., Wolny, M., Wagner, A., Schorr, H., Taban‐Shomal, O., Umanskaya, N., Ross, S., Garcia, P., et al. (2008) · Bone · doi:10.1016/j.bone.2008.10.051 · Cited by 98 · see citing works
Bhattacharjee, N., & Borah, A. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.10.001 · Cited by 81 · see citing works
Chen, S., Dong, Z., Zhao, Y., Sai, N., Wang, X., Liu, H., Huang, G., & Zhang, X. (2017) · Scientific Reports · doi:10.1038/s41598-017-07112-z · Cited by 71 · see citing works
Khan, M. B., Yamauchi, M., Srisawasdi, S., Stiner, D., Doty, S. B., Paschalis, E. P., & Boskey, A. L. (2001) · Bone · doi:10.1016/s8756-3282(01)00409-4 · Cited by 61 · see citing works
PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes
Ma, C.-H., Wu, C.-H., Jou, I., Tu, Y.-K., Hung, C., Hsieh, P., & Tsai, K. (2017) · Redox Biology · doi:10.1016/j.redox.2017.08.011 · Cited by 57 · see citing works
Self-citationRole of mtDNA Haplogroups in the Prevalence of Knee Osteoarthritis in a Southern Chinese Population
Fang, H., Liu, X., Shen, L., Li, F., Liu, Y., Chi, H., Miao, H., Lü, J., & Bai, Y. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15022646 · Cited by 52 · see citing works
LEF1‐mediated MMP13 gene expression is repressed by SIRT1 in human chondrocytes
Elayyan, J., Lee, E. J., Gabay, O., Smith, C. A., Qiq, O., Reich, E., Mobasheri, A., Henrotin, Y. E., Kimber, S. J., & Dvir‐Ginzberg, M. (2017) · The FASEB Journal · doi:10.1096/fj.201601253r · Cited by 52 · see citing works
Mitochondrial epigenetics in bone remodeling during hyperhomocysteinemia
Kalani, A., Kamat, P. K., Voor, M. J., Tyagi, S. C., & Tyagi, N. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2114-3 · Cited by 26 · see citing works
Yui, N., Yoshioka, H., Fujiya, H., Musha, H., Beppu, M., Karasawa, R., & Yudoh, K. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150914921 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The sirtuin family in health and disease
Wu, Q., Zhang, T., Chen, H., Yu, X., Lv, J.-L., Liu, Y., Liu, Y., Zheng, G., Zhao, J.-Q., Wei, Y., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01257-8 · Cited by 891 · see citing works
He, Y., Li, Z. A., Alexander, P. G., Ocasio-Nieves, B. D., Yocum, L., Lin, H., & Tuan, R. S. (2020) · Biology · doi:10.3390/biology9080194 · Cited by 400 · see citing works
Zhang, X., Huang, Z., Xie, Z., Chen, Y., Zheng, Z., Wei, X., Huang, B. H., Shan, Z., Liu, J., Fan, S., et al. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.08.029 · Cited by 188 · see citing works
Homocysteine and age-associated disorders
Ostrakhovitch, E. A., & TABIBZADEH, S. S. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.10.010 · Cited by 182 · see citing works
Mitochondria: Potential Targets for Osteoarthritis
Mao, X.-J., Fu, P., Wang, L.-L., & Xiang, C. (2020) · Frontiers in Medicine · doi:10.3389/fmed.2020.581402 · Cited by 89 · see citing works
Wang, J., Wang, K., Huang, C., Lin, D., Zhou, Y., Wu, Y., Tian, N., Fan, P., Pan, X., Xu, D., et al. (2018) · International Journal of Biological Sciences · doi:10.7150/ijbs.27746 · Cited by 83 · see citing works
Chen, Y., Wu, Y., Si, H., Lu, Y., & Shen, B. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105497 · Cited by 77 · see citing works
AMPK Signaling in Energy Control, Cartilage Biology, and Osteoarthritis
Yi, D., Yu, H., Lu, K., Ruan, C., Ding, C., Tong, L., Zhao, X., & Chen, D. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.696602 · Cited by 75 · see citing works
The role and intervention of mitochondrial metabolism in osteoarthritis
Qi, Z., Zhu, J., Cai, W., Lou, C., & Li, Z. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-023-04818-9 · Cited by 72 · see citing works
Grabež, M., Škrbić, R., Stojiljković, M. P., Vučić, V., Grujić, V. R., Jakovljevic, V. L., Djuric, D. M., Suručić, R. V., Šavikin, K., Bigović, D., et al. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2302057 · Cited by 71 · see citing works
Xu, M., Feng, M., Peng, H., Qian, Z., Zhao, L., & Wu, S. (2020) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2020.04.097 · Cited by 63 · see citing works
The Metabolic Landscape in Osteoarthritis
Wu, X., Fan, X., Crawford, R., Xiao, Y., & Prasadam, I. (2022) · Aging and Disease · doi:10.14336/ad.2021.1228 · Cited by 60 · see citing works
Henry, Ó. C., & O'Neill, L. A. J. (2025) · European Journal of Immunology · doi:10.1002/eji.202451381 · Cited by 56 · see citing works
Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?
Ledda, C., Cannizzaro, E., Lovreglio, P., Vitale, E., Stufano, A., Montana, A., Volti, G. L., & Rapisarda, V. (2019) · Antioxidants · doi:10.3390/antiox9010030 · Cited by 50 · see citing works
Feng, Z., Huang, Q., Zhang, X., Xu, P., Li, S., Ma, D., & Meng, Q. (2023) · PPAR Research · doi:10.1155/2023/2523536 · Cited by 43 · see citing works
Autophagy and apoptosis: regulatory factors of chondrocyte phenotype transition in osteoarthritis
Liu, Z., Wang, T., Sun, X., & Nie, M. (2023) · Human Cell · doi:10.1007/s13577-023-00926-2 · Cited by 39 · see citing works
Latest Advances in Chondrocyte-Based Cartilage Repair
Li, Y., Lim, R., & Owens, B. D. (2024) · Biomedicines · doi:10.3390/biomedicines12061367 · Cited by 39 · see citing works
Jafarzadeh, S., Nemati, M., Zandvakili, R., & Jafarzadeh, A. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114345 · Cited by 39 · see citing works
Xu, K., liu, X., Ren, G., Yin, D., Guo, S., & Zhao, Y. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.116874 · Cited by 38 · see citing works
SIRT1 in Secretory Organ Cancer
Frazzi, R. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00569 · Cited by 38 · see citing works
Targeting PPARs for therapy of atherosclerosis: A review
Miao, M., Wang, X., Liu, T., Li, Y., Yu, W., Yang, T.-M., & Guo, S. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.125008 · Cited by 40 · see citing works
Hong, H., Chen, L., Zhong, Y., Yang, Z., Li, W., Song, C., & Leng, H. (2023) · Nutrients · doi:10.3390/nu15071636 · Cited by 37 · see citing works
Zhu, J., Zhang, Y., Sun, Y., Yu, F., Lu, Y., Hu, Q., Guo, J., Zhang, H., Chen, T., Lian, F., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02937-z · Cited by 37 · see citing works
Wang, K., Chen, X.-B., Chen, Y., Sheng, S., & Huang, Z.-S. (2020) · Food & Function · doi:10.1039/d0fo01377c · Cited by 35 · see citing works
Saikosaponin D: A potential therapeutic drug for osteoarthritis
Jiang, J., Meng, Y., Hu, S., Botchway, B. O. A., Zhang, Y., & Liu, X. (2020) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.3090 · Cited by 33 · see citing works
Chen, L., Wang, Q., Xu, Y., Zhu, D., Sun, Y., Niu, N., Yao, J., Dong, B.-H., Jiang, S., Tang, L., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.672335 · Cited by 31 · see citing works
Yuan, H., Yu, S., Kim, M., Lee, J., Kang, H., Jang, D., Ramasamy, M. S., & Kim, D. H. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.132453 · Cited by 30 · see citing works
Wang, Y., Hong, Y., Zhang, C., Shen, Y., Pan, Y. S., Chen, R. Z., Zhang, Q., & Chen, Y. H. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13949 · Cited by 25 · see citing works
The dysfunctional lipids in prostate cancer.
Dang, Q., Chen, Y., & Hsieh, J. (2019) · PubMed Central · Cited by 25 · see citing works
Wang, C., Wang, C.-T., Chou, W.-C., Kao, C.-L., & Tsai, K. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.10.154 · Cited by 25 · see citing works
Self-citationLi, Q., Zuo, Z., Pan, Y., Zhang, Q., Li, X., & Jiang, B. (2022) · Cardiovascular Toxicology · doi:10.1007/s12012-022-09760-8 · Cited by 25 · see citing works
PGC-1α in osteoarthritic chondrocytes: From mechanism to target of action
Wang, H., Su, J., Yu, M., Xia, Y., & Wei, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1169019 · Cited by 24 · see citing works
Zhang, M., Mou, L., Liu, S., Sun, F., & Gong, M. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108718 · Cited by 24 · see citing works
Fu, L., Wang, Y., & Hu, Y. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1048122 · Cited by 24 · see citing works
Dual Role of SIRT1 in Autophagy and Lipid Metabolism Regulation in Osteoarthritic Chondrocytes
Papageorgiou, A.-A., Goutas, A., Trachana, V., & Tsezou, A. (2021) · Medicina · doi:10.3390/medicina57111203 · Cited by 22 · see citing works
Burton, L. H., Afzali, M. F., Radakovich, L. B., Campbell, M. A., Culver, L. A., Olver, C. S., & Santangelo, K. S. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.12.257 · Cited by 21 · see citing works
The role of cystatin C as a proteasome inhibitor in multiple myeloma
Jiang, Y., Zhang, J., Zhang, C., Hong, L., Jiang, Y., Lu, L., Huang, H., & Guo, D. (2020) · Hematology · doi:10.1080/16078454.2020.1850973 · Cited by 19 · see citing works
Zhou, Z., Luo, G., Li, C., Zhang, P., Chen, W., Li, X., Tang, J., & Qing, L. (2023) · PubMed Central · Cited by 17 · see citing works
Therapeutic potential of hydrogen sulfide in osteoarthritis development
Song, Y., Wu, S., Zhang, R., Zhong, Q., Zhang, X., & Sun, X. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1336693 · Cited by 17 · see citing works
Huang, H., Wang, Z., Zhang, H., Liang, J., Cao, W.-D., Wu, Q., He, C., & Chen, C. (2019) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b19-00036 · Cited by 17 · see citing works
Chen, K., Qin, C., Ji, C.-Y., Yu, Y., Wu, Y., Xu, L., Jiang, Y., & Zou, G. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.143285 · Cited by 16 · see citing works
CCAL1 enhances osteoarthritis through the NF‐κB/AMPK signaling pathway
Zhu, H., Yan, H., Ma, J., Zhang, H., Zhang, J., Hu, Z., & Guo, Y. (2020) · FEBS Open Bio · doi:10.1002/2211-5463.12989 · Cited by 14 · see citing works
The Gasotransmitter Hydrogen Sulfide (H2S) Prevents Pathologic Calcification (PC) in Cartilage
Nasi, S., Ehirchiou, D., Bertrand, J., Castelblanco, M., Mitchell, J. R., Ishii, I., So, A. K.-L., & Busso, N. (2021) · Antioxidants · doi:10.3390/antiox10091433 · Cited by 14 · see citing works
Pereira, C., Guede, D., Durães, C., Brandão, I., Silva, N., Passos, E., Bernardes, M., Monteiro, R., & Martins, M. J. (2019) · Nutrients · doi:10.3390/nu11102316 · Cited by 13 · see citing works
AMPK, a hub for the microenvironmental regulation of bone homeostasis and diseases
Liu, J., Liu, J.-X., Li, R., Zhang, Z., Zhang, X., Xing, S., Sui, B., Jin, F., Ma, B., & Zheng, C. (2024) · Journal of Cellular Physiology · doi:10.1002/jcp.31393 · Cited by 12 · see citing works
Lee, H., Nam, J., Jang, H., Park, Y., Son, M., Lee, I., Eyun, S., Jeon, J., & Yang, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115426 · Cited by 11 · see citing works
Pu, S., Usuda, K., Nagaoka, K., & Watanabe, G. (2018) · Journal of Veterinary Medical Science · doi:10.1292/jvms.18-0615 · Cited by 11 · see citing works
Zhu, X., Wei, J., Li, J., Zuo, S., Wang, J., & Liu, N. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-00933-0 · Cited by 10 · see citing works
Liu, L., Su, X., Zhao, L., Li, J., Xu, W., Yang, L., Yang, Y.-N., Gao, Y., Chen, K., Gao, Y., et al. (2022) · The journal of nutrition health & aging · doi:10.1007/s12603-022-1840-6 · Cited by 10 · see citing works
Pomegranate Peel Extract Attenuates Isoprenaline-Induced Takotsubo-like Myocardial Injury in Rats
Marinković, S. T., Đukanović, Đ., Duran, M., Bajić, Z., Šobot, T., Uletilović, S., Mandić-Kovačević, N., Cvjetković, T., Maksimović, Ž., Maličević, U., et al. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061697 · Cited by 10 · see citing works
Feng, W.-G., Zhang, Z., Zhao, Z., Liu, H., Hou, J., Wu, J., & Li, S. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202501570 · Cited by 9 · see citing works
Hsieh, P., Tsai, K., Chou, W.-C., Wu, C., Jou, I., Tu, Y., & Ma, C. (2023) · Environmental Toxicology · doi:10.1002/tox.23885 · Cited by 9 · see citing works
Self-citationGut microbiota metabolic pathways: Key players in knee osteoarthritis development
Di, J., Xi, Y., Wu, Y., Di, Y., Xing, X., Zhang, Z., & Xiang, C. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112566 · Cited by 8 · see citing works
Wu, J., Xu, J., Zhang, M., Zhong, J., Gao, W., & Wu, M. (2025) · Advances in Wound Care · doi:10.1089/wound.2024.0270 · Cited by 8 · see citing works
Huang, J., Li, Y., Ye, Q., Li, R., Wang, Y. Z., Wang, Q., & Wang, J. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103829 · Cited by 8 · see citing works
AMPK signaling in osteoarthritis: from mechanisms to targeted therapeutics
Chen, L., Hu, X., Wu, X., Zhang, X., Han, Y., Liu, Y., Chen, G., & Tao, Q. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1681610 · Cited by 9 · see citing works
Cholic acid mitigates osteoarthritis by inhibiting the NF-κB/PERK/SIRT1 signaling pathway
SHENG, J., YI, Z., HE, S., WU, Q., HUANG, X., YAN, G., DAI, Y., & SU, L. (2024) · Biocell · doi:10.32604/biocell.2024.028421 · Cited by 8 · see citing works
Nakano, M., Nakamura, Y., Urano, T., Miyazaki, A., Suzuki, T., Watanabe, K., Takahashi, J. A., & Shiraki, M. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab591 · Cited by 8 · see citing works
Shi, Q.-F., Xu, L., & Zeng, X. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11193 · Cited by 8 · see citing works
Exosomes derived from diabetic serum accelerate the progression of osteoarthritis
Jin, T., Wu, L., Wang, J., Wang, X., He, Z., Di, W., Yang, Q., & Wei, X. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.109960 · Cited by 5 · see citing works
Li, Z., He, M., Dai, D., Gao, X.-F., Liang, H., & Xiong, L. (2023) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.23-0065 · Cited by 4 · see citing works
Quarterman, J. C., Naguib, Y. W., Chakka, L. R. J., Seol, D., Martin, J. A., & Salem, A. K. (2021) · Journal of Pharmaceutical Sciences · doi:10.1016/j.xphs.2021.09.025 · Cited by 4 · see citing works
Adhish, M., & Manjubala, I. (2024) · Biology Direct · doi:10.1186/s13062-024-00581-z · Cited by 4 · see citing works
Co‐culture with Sirt1-overexpressed chondrocytes delays the nucleus pulposus cells degeneration
Lei, B., Wang, K., Yang, D., Liao, L., Dong, X., & Huang, Z. (2021) · Cell and Tissue Banking · doi:10.1007/s10561-021-09912-0 · Cited by 3 · see citing works
Gut microbiota and blood biomarkers in IBD-Related arthritis: insights from mendelian randomization
Yang, W. Q., Cui, M., Yang, P., Liu, C., Xiu-zhen, H., Yao, W., & Li, Z. (2025) · Scientific Reports · doi:10.1038/s41598-024-84116-6 · Cited by 3 · see citing works
Jelodar, G., Azimzadeh, M., Radmard, F., & Darvishhoo, N. (2021) · Toxicology and Industrial Health · doi:10.1177/07482337211022634 · Cited by 3 · see citing works
da Fonseca, L. F., Santos, G. S., Azzini, G. O. M., Mosaner, T., Jorge, D. D. M. F., de Macedo, A. P., Huber, S. C., Sobreiro, P., Dallo, I., Jeyaraman, M., et al. (2024) · International Wound Journal · doi:10.1111/iwj.70056 · Cited by 3 · see citing works
EVALUATION OF HOMOCYSTEINE AND VITAMIN D LEVELS IN OSTEOARTHRITIS PATIENTS
Çıkım, G., & Veranyurt, Ü. (2021) · NWSA Academic Journals · doi:10.12739/nwsa.2021.16.2.1b0109 · Cited by 2 · see citing works
Naik, A. A., & Sivaramakrishnan, V. (2022) · Medical Hypotheses · doi:10.1016/j.mehy.2022.110808 · Cited by 2 · see citing works
Luo, G., Zhou, Z., Li, C., Zhang, P., Chen, W., Li, X., Tang, J., & Qing, L. (2023) · Research Square · doi:10.21203/rs.3.rs-2700955/v1 · Cited by 2 · see citing works
Shi, Y., Lu, M., He, F., Chen, J., Zheng, C., & Lu, L. (2024) · Hormone and Metabolic Research · doi:10.1055/a-2460-7718 · Cited by 1 · see citing works
Mariano, A., d’Abusco, A. S., & Ammendola, S. (2026) · Nutrients · doi:10.3390/nu18061003 · Cited by 1 · see citing works
石云锋, & Xia, S. (2026) · Current Issues in Molecular Biology · doi:10.3390/cimb48060642 · Cited by 1 · see citing works
Liu, B., Yang, S., Yang, L., Zhang, B., & Guo, R. (2022) · Cardiology Plus · doi:10.1097/cp9.0000000000000016
Zhao, T., Xie, F., Zhao, T., & Ding, Y. (2022) · Journal of Biomedical Nanotechnology · doi:10.1166/jbn.2022.3379
Role and Application of Biomolecules for Regeneration of Cartilage Tissue
Nakamichi, R., Fujii, Y., & Asahara, H. (2023) · Springer eBooks · doi:10.1007/978-981-99-2452-3_7
Folate deficiency and total shoulder arthroplasty outcomes
Saha, P., Mousavi, S. Z., Astavans, A., Agarwal, S., Fox, H., Schmucker, A., & Srikumaran, U. (2025) · Shoulder & Elbow · doi:10.1177/17585732251362442
Deng, C., He, Z., & Zhu, X. (2026) · SAGE Open Medicine · doi:10.1177/20503121251410051
Meng, Z., Hu, Y., Wu, Z., Chen, X., Li, Y., Balogun, M., Yang, H., Liu, W., & Wei, Q. (2026) · Microchemical Journal · doi:10.1016/j.microc.2026.118005
Msigwa, S. S., Mkwambe, M. C., Yu, Q., Zhu, S.-G., Zhu, J., Zhang, X., & Wang, J. (2026) · Annals of Medicine · doi:10.1080/07853890.2026.2654251
Xu, Y., Xia, K., Mao, X., Yao, J., Hou, B., Wang, W., & Hao, Z. (2026) · Journal of Molecular Medicine · doi:10.1007/s00109-026-02687-5
Xiong, F., Xu, Y., Wang, X., Peng, Y., Tang, T., Jiang, K., Wang, R., Wu, Y. J., Wang, H., Li, C., et al. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158456
Energy crisis and cartilage collapse: metabolic reprogramming of chondrocytes in osteoarthritis
Yang, F., Wang, Q. L., Zhu, X., Yizhi, Y., Yu, T., & Xiao, X. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1834080
Zhan, D., Chen, P., Li, J., Yang, Y., Sun, W., Chen, Q., Zhang, X., & Zhao, H. (2026) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/s13034-026-01144-y
Homocysteine and mitophagy in diabetic retinopathy: unraveling the underlying molecular crosstalk
Tan, N., Chen, Y., Li, M., Liu, W., Li, X., Li, P., & 雷迅文 (2026) · Endocrine · doi:10.1007/s12020-026-04787-1
SIRT1/PGC-1α-regulated mitochondrial biogenesis is involved in T-2 toxin-induced chondrocyte injury
Wang, C., Junfeng, Z., Zhang, W., Zhao, Y., Li, J., Li, J., Yu, J., & 崔丝露 (2026) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2026.120822
- Authors
- Ma, C.-H., Chiua, Wu, C.-H., Jou, I.-M., Tu, Y.-K., Hung, C.-H., Hsieh, P.-L., & Tsai, K.-L.
- Affiliations
- E-Da Hospital (TW)
- National Cheng Kung University (TW)
- Chung Shan Medical University (TW)
- Corresponding author
- Hsieh, Pei-Ling
- Tsai, Kun-Ling
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2018-05
- Volume
- 15
- Pages
- 504-512
- ISSN
- 2213-2317 (ISSN-L)
- PMC
- PMC5881416
- OpenAlex
- W2790970464
- Cited by
- 86
- References
- 36
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 9 · 2023: 13 · 2022: 11 · 2021: 12 · 2020: 9 · 2019: 5 · 2018: 5
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Redox Biology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Ministry of Science and Technology, Taiwan (105-2311-B-006-008, 106-2314-B-006-023)
- National Cheng Kung University
- Ministerio de Ciencia y Tecnología
- E-Da Hospital (NCKUEDA10613)
- Topics
- Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Keywords
- homocysteine, hyperhomocysteinemia, osteoarthritis, chondrocytes, SIRT1, AMPK, PGC-1α, PPARγ, mitochondrial dysfunction, oxidative stress, apoptosis, MMP-13, cyclooxygenase-2, NF-κB, cartilage degeneration
- MeSH terms
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, AMP-Activated Protein Kinase Kinases, Animals, Gene Expression Regulation, Homocysteine, Humans, Mitochondria, Osteoarthritis, Protein Kinases, Signal Transduction, Oxidative Stress, Chondrocytes, Hyperhomocysteinemia, PPAR gamma, Mice, Cyclooxygenase 2, Matrix Metalloproteinase 13, Sirtuin 1
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