PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

Purpose of review Peroxisome proliferator-activated receptor gamma coactivator-1-α (PGC-1α) has been extensively described as a master regulator of mitochondrial biogenesis. However, PGC-1α activity is not constant and can be finely tuned in response to different metabolic situations. From this p…