CoChat
Sign Up
Cited by 771Frailty in Older AdultsNutrition and Health in AgingPhysical Activity and Health

The DOI matches its Crossref record; 321 of the 321 references it cites were found in a registry or an index.

Physical activity and exercise: Strategies to manage frailty

Open access
Angulo, Javier, El Assar, Mariam, Álvarez-Bustos, Alejandro, Rodríguez-Mañas, Leocadio·2020·Redox Biology
DOI 10.1016/j.redox.2020.101513PMC PMC7284931
Open this paper in CoChat — free accountOpen PDF

Abstract

Frailty, a consequence of the interaction of the aging process and certain chronic diseases, compromises functional outcomes in the elderly and substantially increases their risk for developing disabilities and other adverse outcomes. Frailty follows from the combination of several impaired physiological mechanisms affecting multiple organs and systems. And, though frailty and sarcopenia are related, they are two different conditions. Thus, strategies to preserve or improve functional status should consider systemic function in addition to muscle conditioning. Physical activity/exercise is considered one of the main strategies to counteract frailty-related physical impairment in the elderly. Exercise reduces age-related oxidative damage and chronic inflammation, increases autophagy, and improves mitochondrial function, myokine profile, insulin-like growth factor-1 (IGF-1) signaling pathway, and insulin sensitivity. Exercise interventions target resistance (strength and power), aerobic, balance, and flexibility work. Each type improves different aspects of physical functioning, though they could be combined according to need and prescribed as a multicomponent intervention. Therefore, exercise intervention programs should be prescribed based on an individual's physical functioning and adapted to the ensuing response.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.redox.2020.101513

Cites

321 of 321 references verified0 citation errors · 0 not checkable

Statistics

Figures

Fig. 1 Three different trajectories of intrinsic capacity along the lifetime: Accelerated aging, usual aging, and successful/healthy aging. Trajectories are suitable for intervention, acting on the rate of decrease in intrinsic capacity.
Fig. 1 Three different trajectories of intrinsic capacity along the lifetime: Accelerated aging, usual aging, and successful/healthy aging. Trajectories are suitable for intervention, acting on the rate of decrease in intrinsic capacity.CC BY-NC-ND · PubMed Central
Fig. 2 Shortening of intrinsic capacity and functional reserve leading to frailty and, if no intervention, to disability and death. As these shortages progress, the likelihood of reversing functional impairment decreases. When the threshold for disability is crossed, the possibility of restoring robustness is uncertain.
Fig. 2 Shortening of intrinsic capacity and functional reserve leading to frailty and, if no intervention, to disability and death. As these shortages progress, the likelihood of reversing functional impairment decreases. When the threshold for disability is crossed, the possibility of restoring robustness is uncertain.CC BY-NC-ND · PubMed Central
Fig. 3 The spectrum of intrinsic capacity from the perspectives of organ and systemic level, and their clinical manifestations. In the first stages, there are changes in isolated organs that can still be reversed and do not impact function due to a high functional reserve. As the condition progresses, other organs start to deteriorate, due to the aging processes or to the accumulation of chronic diseases sharing similar mechanisms of damage. At this stage frailty status appears: there is still enough functional reserve to maintain functional autonomy, although some deterioration in performance-based tasks can be observed if carefully assessed. If the condition continues progressing, functional reserve is depleted and disability takes hold, with few chances for recovery.
Fig. 3 The spectrum of intrinsic capacity from the perspectives of organ and systemic level, and their clinical manifestations. In the first stages, there are changes in isolated organs that can still be reversed and do not impact function due to a high functional reserve. As the condition progresses, other organs start to deteriorate, due to the aging processes or to the accumulation of chronic diseases sharing similar mechanisms of damage. At this stage frailty status appears: there is still enough functional reserve to maintain functional autonomy, although some deterioration in performance-based tasks can be observed if carefully assessed. If the condition continues progressing, functional reserve is depleted and disability takes hold, with few chances for recovery.CC BY-NC-ND · PubMed Central
Fig. 4 Aging together with increase in oxidative damage and chronic inflammation represent three interrelated age-dependent processes that provide a background prone to organic systems dysfunction and age-related chronic diseases. The interaction between age-related chronic diseases, aging process, oxidative stress, and inflammation may lead to multisystem dysfunction and frailty phenotype in the elderly.
Fig. 4 Aging together with increase in oxidative damage and chronic inflammation represent three interrelated age-dependent processes that provide a background prone to organic systems dysfunction and age-related chronic diseases. The interaction between age-related chronic diseases, aging process, oxidative stress, and inflammation may lead to multisystem dysfunction and frailty phenotype in the elderly.CC BY-NC-ND · PubMed Central
Fig. 5 Aging process is associated with increased reactive oxygen species (ROS) and inflammation resulting in muscle dysfunction. Decreased levels of insulin-like growth factor (IGF-1) are related to aging with the subsequent diminished protein synthesis and muscle growth via phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Exercise may exert potent anti-inflammatory and anti-oxidative stress (i.e., through nuclear erythroid-2 like factor-2 (Nrf-2) activation) effects and consequently improve muscle function. In addition, exercise increases protein synthesis via activation of IGF-1 pathway and target myokines reducing protein degradation. An increased signaling of the transcription factor peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is also induced by exercise, improving mitochondrial function and reducing inflammation mediated by nuclear factor κB (NF-κB).
Fig. 5 Aging process is associated with increased reactive oxygen species (ROS) and inflammation resulting in muscle dysfunction. Decreased levels of insulin-like growth factor (IGF-1) are related to aging with the subsequent diminished protein synthesis and muscle growth via phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway. Exercise may exert potent anti-inflammatory and anti-oxidative stress (i.e., through nuclear erythroid-2 like factor-2 (Nrf-2) activation) effects and consequently improve muscle function. In addition, exercise increases protein synthesis via activation of IGF-1 pathway and target myokines reducing protein degradation. An increased signaling of the transcription factor peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is also induced by exercise, improving mitochondrial function and reducing inflammation mediated by nuclear factor κB (NF-κB).CC BY-NC-ND · PubMed Central
Fig. 6 Physical activity/exercise training may influence the outcome of the aging process by modulating key signaling pathways. Exercising results in reduced age-related oxidative damage, reduced chronic inflammation, increased autophagy, improved mitochondrial function, improved myokine profile, augmented insulin-like growth factor-1 (IGF-1) signaling, and insulin sensitivity. These actions promote beneficial effects on skeletal muscle (muscle mass, strength, and function) but also at systemic level, inducing improvements in function of cardiovascular, respiratory and metabolic systems. Exercise-induced improvements in muscle function as well as systemic benefits and age-related chronic diseases alleviation are all related to the improvements in physical function and frailty improvement by exercise/physical activity.
Fig. 6 Physical activity/exercise training may influence the outcome of the aging process by modulating key signaling pathways. Exercising results in reduced age-related oxidative damage, reduced chronic inflammation, increased autophagy, improved mitochondrial function, improved myokine profile, augmented insulin-like growth factor-1 (IGF-1) signaling, and insulin sensitivity. These actions promote beneficial effects on skeletal muscle (muscle mass, strength, and function) but also at systemic level, inducing improvements in function of cardiovascular, respiratory and metabolic systems. Exercise-induced improvements in muscle function as well as systemic benefits and age-related chronic diseases alleviation are all related to the improvements in physical function and frailty improvement by exercise/physical activity.CC BY-NC-ND · PubMed Central
Fig. 7 Distribution of the type of exercises in a standard training session according to patient frailty status. Intensity should generally increase as the frailty status improves, although High Interval Intensity Training-HIIT can be used also in frail patients.
Fig. 7 Distribution of the type of exercises in a standard training session according to patient frailty status. Intensity should generally increase as the frailty status improves, although High Interval Intensity Training-HIIT can be used also in frail patients.CC BY-NC-ND · PubMed Central

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 321 references

Research works printed but not linked: 2

  1. Marengoni, 2018, The relationship between COPD and frailty: a systematic review and meta-analysis of observational studies, Chest, 154, 21, 10.1016/j.chest.2018.02.014 · DOI
  2. Wohlgemuth, 2011, An exploratory analysis of the effects of a weight loss plus exercise program on cellular quality control mechanisms in older overweight women, Rejuvenation Res., 14, 315, 10.1089/rej.2010.1132 · DOI · Paper page

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Angulo, J., El Assar, M., Álvarez-Bustos, A., & Rodríguez-Mañas, L.
Affiliations
Universidad Francisco de Vitoria (ES)
ORCID
Angulo, Javier
Venue
Redox Biology
Publisher
Elsevier BV
Published
2020-08
Volume
35
Pages
101513
ISSN
2213-2317 (ISSN-L)
DOI
10.1016/j.redox.2020.101513
PMC
PMC7284931
OpenAlex
W3011192505
Cited by
771
References
321
Citations by year
2026: 124 · 2025: 200 · 2024: 198 · 2023: 122 · 2022: 76 · 2021: 35 · 2020: 15
FWCI
7.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Redox Biology (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Deposito Digital UFV (Francisco de Vitoria University) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CB16/10/00464)
  • Instituto de Salud Carlos III (PI15/00674, PI15/01160)
  • European Regional Development Fund
  • Seventh Framework Programme
  • Ministerio de Economía y Competitividad
  • Innovative Medicines Initiative
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
Keywords
frailty, physical activity, exercise intervention, older adults, sarcopenia, functional status, resistance training, aerobic exercise, balance training, flexibility training, oxidative stress, chronic inflammation, autophagy, mitochondrial function, myokines, IGF-1 signaling, insulin sensitivity, multicomponent exercise
MeSH terms
Frailty, Adaptation, Physiological, Aged, Exercise Therapy, Humans, Exercise, Frail Elderly, Sarcopenia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review