ZnR/GPR39 regulates hepatic insulin signaling, tunes liver bioenergetics and ROS production, and mitigates liver fibrosis and injury
Open accessAbstract
Adequate supply of zinc is essential for hepatic function and its deficiency is associated with acute liver injury (ALI) and chronic nonalcoholic fatty liver disease (NAFLD). However, how zinc controls hepatic function is unknown. We found that the zinc sensitive ZnR/GPR39, a mediator of zinc signaling, enhances hepatic phosphorylation of ERK1/2, which is reduced in ZnR/GPR39 deficient livers. Surprisingly, livers from ZnR/GPR39 knockout (KO) mice exhibited elevated insulin receptor expression and downstream AKT activation. Moreover, ZnR/GPR39 KO mice had higher blood fasting glucose level, pronounced hepatic lipid accumulation, increased hepatocyte oxygen consumption rate (OCR) and reactive oxygen species (ROS) levels. These data suggest that ZnR/GPR39 modulates insulin receptor signaling, a major pathway in hepatic metabolism. Associated with the impaired signaling, ZnR/GPR39 KO livers exhibited increased tissue fibrosis, manifested by marked elevation of collagen expression, compared to wildtype (WT). Additionally, we found alteration of hepatocyte junctional proteins that was accompanied by increased macrophage infiltration and higher liver inflammation in ZnR/GPR39 KO mice. To determine the role of ZnR/GPR39 in ALI, we applied a mild LPS challenge that induced profound decrease in hepatic OCR, also leading to higher ROS generation in ZnR/GPR39 KO hepatocytes, but not in WT. We further found increased serum IL-2 and AST/ALT ratio only in ZnR/GPR39 KO mice. Our findings reveal a role of ZnR/GPR39 in controlling hepatic insulin receptor signaling and mitigating liver fibrosis and inflammation, thus underscoring the important role of ZnR/GPR39 in liver signaling and function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Metal ion-based loading of proteases effectively addressed the challenge of insufficient enzyme activity in the lesion area due to depletion of metal ions such as zinc ions.
“Simultaneously, the metal ion–based loading of proteases effectively addressed the challenge of insufficient enzyme activity in the lesion area due to the depletion of metal ions (such as zinc ions) (45, 46).”
From Matrix mechanical remodeled carrier-free nanosystem for programmable closed-loop reversal of liver fibrosis via STING alkylation (2025) · cites this paper as [46]
The Introduction (page unavailable) discusses zinc deficiency and impaired liver function, but not protease loading or enzyme activity at a lesion. Searches for metal-ion-based protease loading and zinc-depletion-related protease activity found no passage addressing the claimed intervention. (LLM, conf=0.76)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nolfi-Donegan, D., Braganza, A., & Shiva, S. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101674 · Cited by 1,488 · see citing works
Mitochondrial electron transport chain, ROS generation and uncoupling (Review)
Zhao, R., Jiang, S., Zhang, L., & Yu, Z. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4188 · Cited by 1,415 · see citing works
β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis
Monga, S. P. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.02.056 · Cited by 485 · see citing works
Advances in measuring cellular bioenergetics using extracellular flux
Ferrick, D. A., Neilson, A., & Beeson, C. C. (2008) · Drug Discovery Today · doi:10.1016/j.drudis.2007.12.008 · Cited by 455 · see citing works
Tight junction proteins in gastrointestinal and liver disease
Zeisel, M. B., Dhawan, P., & Baumert, T. F. (2018) · Gut · doi:10.1136/gutjnl-2018-316906 · Cited by 373 · see citing works
Zinc and immunity: An essential interrelation
Maares, M., & Haase, H. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.03.022 · Cited by 359 · see citing works
Bo, T., Gao, L., Yao, Z., Shao, S., Wang, X., Proud, C. G., & Zhao, J. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.04.006 · Cited by 293 · see citing works
Tang, X.-H., & Shay, N. F. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.5.1414 · Cited by 288 · see citing works
Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases
van der Heide, D., Weiskirchen, R., & Bansal, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02852 · Cited by 234 · see citing works
Ambade, A., Lowe, P., Kodys, K., Catalano, D. E., Gyöngyösi, B., Cho, Y., Iracheta‐Vellve, A., Adejumo, A., Saha, B., Calenda, C. D., et al. (2018) · Hepatology · doi:10.1002/hep.30249 · Cited by 213 · see citing works
The role of zinc in liver cirrhosis
Grüngreiff, K., Reinhold, D., & Wedemeyer, H. H. (2015) · Annals of Hepatology · doi:10.5604/16652681.1184191 · Cited by 211 · see citing works
Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl‐CoA
Ngo, J., Choi, D. W., Stanley, I. A., Stiles, L., Molina, A. J. A., Chen, P., Lako, A., Sung, I. C. H., Goswami, R., Kim, M., et al. (2023) · The EMBO Journal · doi:10.15252/embj.2022111901 · Cited by 178 · see citing works
Himoto, T., & Masaki, T. (2018) · Nutrients · doi:10.3390/nu10010088 · Cited by 175 · see citing works
Haase, H., & Maret, W. (2005) · BioMetals · doi:10.1007/s10534-005-3707-9 · Cited by 173 · see citing works
Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse.
Moechars, D., Depoortere, I., Moreaux, B., de Smet, B., Goris, I., Hoskens, L., Daneels, G., Kass, S. U., Donck, L. V., Peeters, T., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.07.009 · Cited by 168 · see citing works
Wei, C., Luo, Z., Högstrand, C., Xu, Y., Wu, L., Chen, G., Pan, Y., & Song, Y. (2018) · The FASEB Journal · doi:10.1096/fj.201800463 · Cited by 167 · see citing works
Zinc and the Liver: An Active Interaction
Stamoulis, I., Kouraklis, G., & Theocharis, S. E. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9462-0 · Cited by 162 · see citing works
Kučera, O., Endlicher, R., Roušar, T., Lotková, H., Garnol, T., Drahota, Z., & Červinková, Z. (2014) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2014/752506 · Cited by 138 · see citing works
Loss of liver E-cadherin induces sclerosing cholangitis and promotes carcinogenesis
Nakagawa, H., Hikiba, Y., Hirata, Y., Font-Burgada, J., Sakamoto, K., Hayakawa, Y., Taniguchi, K., Umemura, A., Kinoshita, H., Sakitani, K., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322731111 · Cited by 132 · see citing works
Haase, H., & Maret, W. (2005) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2005.02.004 · Cited by 125 · see citing works
Popovics, P., & Stewart, A. J. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0517-1 · Cited by 120 · see citing works
Sharir, H., Zinger, A., Nevo, A., Sekler, I., & Hershfinkel, M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.107490 · Cited by 114 · see citing works
Self-citationAzriel-Tamir, H., Sharir, H., Schwartz, B., & Hershfinkel, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406581200 · Cited by 111 · see citing works
Self-citationHow cellular Zn2+ signaling drives physiological functions
Levaot, N., & Hershfinkel, M. (2018) · Cell Calcium · doi:10.1016/j.ceca.2018.08.004 · Cited by 110 · see citing works
Self-citationPreventing and Controlling Zinc Deficiency Across the Life Course: A Call to Action
Lowe, N. M., Hall, A. G., Broadley, M. R., Foley, J. K., Boy, E., & Bhutta, Z. A. (2024) · Advances in Nutrition · doi:10.1016/j.advnut.2024.100181 · Cited by 110 · see citing works
Mir, H., Meena, A. S., Chaudhry, K. K., Shukla, P. K., Gangwar, R., Manda, B., Padala, M. K., Shen, L., Turner, J. R., Dietrich, P., et al. (2015) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2015.12.013 · Cited by 109 · see citing works
Zinc metabolism and homeostasis: The application of tracer techniques to human zinc physiology
Krebs, N. F., & Hambidge, K. M. (2001) · BioMetals · doi:10.1023/a:1012942409274 · Cited by 107 · see citing works
Ferriero, R., Nusco, E., Cegli, R. D., Carissimo, A., Manco, G., & Brunetti‐Pierri, N. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2018.03.016 · Cited by 103 · see citing works
Hu, Y., Xuefeng, Y., Shandong, W., & Jianhua, X. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.03.024 · Cited by 97 · see citing works
Norouzi, S., Adulcikas, J., Sohal, S. S., & Myers, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191727 · Cited by 95 · see citing works
Matsumoto, K., Imasato, M., Yamazaki, Y., Tanaka, H., 渡辺, 光., Eguchi, H., Nagano, H., Hikita, H., Tatsumi, T., Takehara, T., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.07.033 · Cited by 94 · see citing works
The Zinc Sensing Receptor, ZnR/GPR39, in Health and Disease
Hershfinkel, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19020439 · Cited by 94 · see citing works
Self-citationMicronutrients in Nonalcoholic Fatty Liver Disease Pathogenesis
Pickett‐Blakely, O., Young, K. A., & Carr, R. M. (2018) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2018.07.004 · Cited by 91 · see citing works
Cohen, L., Sekler, I., & Hershfinkel, M. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.262 · Cited by 90 · see citing works
Self-citationHepatic ZIP14-mediated zinc transport is required for adaptation to endoplasmic reticulum stress
Kim, M., Aydemir, T. B., Kim, J.-H., & Cousins, R. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1704012114 · Cited by 87 · see citing works
The Many Roles of Cell Adhesion Molecules in Hepatic Fibrosis
Hintermann, E., & Christen, U. (2019) · Cells · doi:10.3390/cells8121503 · Cited by 87 · see citing works
Frades, I., Andréasson, E., Mato, J. M., Alexandersson, E., Matthiesen, R., & Martínez‐Chantar, M. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124544 · Cited by 86 · see citing works
Aydemir, T. B., Sitren, H. S., & Cousins, R. J. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.02.046 · Cited by 79 · see citing works
Carchman, E. H., Whelan, S., Loughran, P., Mollen, K. P., Stratamirovic, S., Shiva, S., Rosengart, M. R., & Zuckerbraun, B. S. (2013) · The FASEB Journal · doi:10.1096/fj.13-229476 · Cited by 77 · see citing works
Catalán, V., Gómez‐Ambrosi, J., Rotellar, F., Silva, C., Gil, M. J. C., Rodrı́guez, A., Cienfuegos, J. A., Salvador, J., & Frühbeck, G. (2007) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2007.02777.x · Cited by 74 · see citing works
Hepatic insulin receptor: new views on the mechanisms of liver disease
Lee, W., Najjar, S. M., Kahn, C. R., & Hinds, T. D. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155607 · Cited by 69 · see citing works
Tight Junction Proteins and the Biology of Hepatobiliary Disease
Roehlen, N., Suarez, A. A. R., Saghire, H. E., Saviano, A., Schuster, C., Lupberger, J., & Baumert, T. F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030825 · Cited by 69 · see citing works
Disruption of G Protein-Coupled Receptor 39 Impairs Insulin Secretion in Vivo
Tremblay, F., Richard, A.-M. T., Will, S., Syed, J., Stedman, N., Perreault, M., & Gimeno, R. E. (2009) · Endocrinology · doi:10.1210/en.2008-1251 · Cited by 67 · see citing works
Dysregulated Bile Transporters and Impaired Tight Junctions During Chronic Liver Injury in Mice
Pradhan‐Sundd, T., Vats, R., Russell, J. O., Singh, S., Michael, A. A., Molina, L. M., Kakar, S., Cornuet, P. K., Poddar, M., Watkins, S. C., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.06.048 · Cited by 66 · see citing works
Vanasco, V., Cimolai, M. C., Evelson, P., & Álvarez, S. (2008) · Free Radical Research · doi:10.1080/10715760802438709 · Cited by 64 · see citing works
Aydemir, T. B., Troche, C., Kim, M., & Cousins, R. J. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.748632 · Cited by 63 · see citing works
The Role of Macrophages in Liver Fibrosis: New Therapeutic Opportunities
Binatti, E., Gerussi, A., Barisani, D., & Invernizzi, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126649 · Cited by 62 · see citing works
The zinc sensing receptor ZnR GPR39 in health and disease
Hershfinkel, M. (2017) · Frontiers in bioscience · doi:10.2741/4554 · Cited by 61 · see citing works
Self-citationDeficiency of the GPR39 receptor is associated with obesity and altered adipocyte metabolism
Petersen, P. S., Jin, C., Madsen, A. N., Rasmussen, M., Kuhre, R. E., Egerod, K. L., Nielsen, L. B., Schwartz, T. W., & Holst, B. (2011) · The FASEB Journal · doi:10.1096/fj.11-184531 · Cited by 55 · see citing works
Biological Role of Zinc in Liver Cirrhosis: An Updated Review
Ullah, M. I., Alameen, A. A. M., Al‐Oanzi, Z. H., Eltayeb, L. B., Atif, M., Munir, M. U., & Ejaz, H. (2023) · Biomedicines · doi:10.3390/biomedicines11041094 · Cited by 52 · see citing works
Sunuwar, L., Medini, M., Cohen, L., Sekler, I., & Hershfinkel, M. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0420 · Cited by 52 · see citing works
Self-citationInsulin Regulation of Hepatic Lipid Homeostasis
Uehara, K., Santoleri, D., Whitlock, A. E. G., & Titchenell, P. M. (2023) · Comprehensive Physiology · doi:10.1002/cphy.c220015 · Cited by 49 · see citing works
Low Levels of Lipopolysaccharide Modulate Mitochondrial Oxygen Consumption in Skeletal Muscle
Frisard, M. I., Wu, Y., McMillan, R. P., Voelker, K. A., Wahlberg, K. A., Anderson, A. S., Boutagy, N. E., Resendes, K., Ravussin, É., & Hulver, M. W. (2014) · Metabolism · doi:10.1016/j.metabol.2014.11.007 · Cited by 49 · see citing works
Einhorn, V., Haase, H., & Maares, M. (2024) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2024.127459 · Cited by 47 · see citing works
Shao, Y., Lei, Z., Wolf, P. G., Gao, Y. Q., Guo, Y., & Zhang, B. (2017) · Journal of Nutrition · doi:10.3945/jn.116.243238 · Cited by 45 · see citing works
Decreased expression of ZO‑1 is associated with tumor metastases in liver cancer
Zhang, X., Wang, L., Zhang, H., Tu, F., Qiang, Y., & Nie, C. (2018) · Oncology Letters · doi:10.3892/ol.2018.9765 · Cited by 42 · see citing works
Aquaporin-9 facilitates liver regeneration following hepatectomy
Zhang, B., Lv, D., Chen, Y., Nie, W., Jiao, Y., Zhang, J., Zhou, X., Wu, X. M., Chen, S., & Ma, T. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102246 · Cited by 40 · see citing works
Bloom, A., Bloom, S., Silva, H., Nicoll, A., & Sawhney, R. (2021) · Annals of Hepatology · doi:10.1016/j.aohep.2021.100549 · Cited by 35 · see citing works
Ito, T., Ishigami, M., Ishizu, Y., Kuzuya, T., Honda, T., Ishikawa, T., Toyoda, H., Kumada, T., & Fujishiro, M. (2019) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000001587 · Cited by 34 · see citing works
Xiao, C., Comer, L., Pan, X., Everaert, N., Schroyen, M., & Song, Z. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116111 · Cited by 32 · see citing works
Sunuwar, L., Asraf, H., Donowitz, M., Sekler, I., & Hershfinkel, M. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.01.009 · Cited by 31 · see citing works
Self-citationThe multifaceted role of macrophages during acute liver injury
Hassan, G. S., Molina, M. F., & Shoukry, N. H. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1237042 · Cited by 29 · see citing works
Zi, Z., & Rao, Y. (2024) · Science Advances · doi:10.1126/sciadv.adj0146 · Cited by 27 · see citing works
HSF2BP protects against acute liver injury by regulating HSF2/HSP70/MAPK signaling in mice
Bi, J., Zhang, J., Ke, M., Wang, T., Wang, M., Liu, W., Du, Z., Ren, Y., Zhang, S., Wu, Z., et al. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-05282-x · Cited by 25 · see citing works
The zonula occludens protein family regulates the hepatic barrier system in the murine liver
Itoh, M., Terada, M., & Sugimoto, H. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165994 · Cited by 24 · see citing works
Selective suppression of M1 macrophages is involved in zinc inhibition of liver fibrosis in mice
Xie, C., Wan, L., Li, C., Feng, Y., & Kang, Y. J. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108802 · Cited by 22 · see citing works
Interleukins in liver disease treatment
Yang, M. J., & Zhang, C. (2024) · World Journal of Hepatology · doi:10.4254/wjh.v16.i2.140 · Cited by 20 · see citing works
Gatiatulina, E. R., Sheina, E. A., Немерешина, О. Н., Popova, E. V., Polyakova, V. S., Agletdinov, E. F., Синицкий, А. И., Skalny, A. V., Nikonorov, A. А., & Tinkov, A. A. (2019) · Biological Trace Element Research · doi:10.1007/s12011-019-01985-z · Cited by 20 · see citing works
Liver cirrhosis and “liver” diabetes mellitus are linked by zinc deficiency
Grüngreiff, K., & Reinhold, D. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.04.030 · Cited by 19 · see citing works
Kim, M., Aydemir, T. B., & Cousins, R. J. (2016) · Journal of Nutrition · doi:10.3945/jn.116.237495 · Cited by 19 · see citing works
Cross‐talk between zinc and calcium regulates ion transport: A role for the zinc receptor, ZnR/GPR39
Hershfinkel, M. (2023) · The Journal of Physiology · doi:10.1113/jp283834 · Cited by 19 · see citing works
Self-citationAbdallah, A. A. M., Abdelrahman, M. M., Al-Amir, H., Hafez, A., Rashed, S. A., Amin, Y. A., & Hemdan, S. B. (2022) · Nutrition and Health · doi:10.1177/02601060221103032 · Cited by 18 · see citing works
Xu, Y.-C., Zheng, H., Högstrand, C., Tan, X.-Y., Zhao, T., Song, Y., Wei, X., Wu, L., & Luo, Z. (2023) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2023.109429 · Cited by 16 · see citing works
E-cadherin, guardian of liver physiology
Gonzalez‐Sanchez, E., Vaquero, J., Fouassier, L., & Chignard, N. (2014) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2014.09.008 · Cited by 16 · see citing works
Sato, H., Tanaka, T., & Tanaka, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030124 · Cited by 15 · see citing works
Aksoy, Z. B., Bitirim, C. V., Turan, B., & Akçalı, K. C. (2024) · Biological Trace Element Research · doi:10.1007/s12011-023-04057-5 · Cited by 13 · see citing works
Tyczyńska, M., Hunek, G., Szczasny, M., Brachet, A., Januszewski, J., Forma, A., Portincasa, P., Flieger, J., & Baj, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094916 · Cited by 13 · see citing works
Mapping Novel Biomarkers of Liver Injury by Tissue Proteomic Analysis
Yang, B. H., Zhang, J., Sun, L., Huang, T., Kong, Y., Li, L., Sun, Z., Yin, M., & Li, X. (2021) · ACS Omega · doi:10.1021/acsomega.1c00152 · Cited by 12 · see citing works
Ye, M., He, Y., Xia, Y. Y., Zhong, Z., Kong, X., Zhou, Y., Xia, W., Wang, W., Fan, H., Chen, L., et al. (2024) · Biological Trace Element Research · doi:10.1007/s12011-024-04261-x · Cited by 10 · see citing works
Ostadmohammadi, V., Namazi, M. J., Rezasoltani, M., Kheirkhah, D., Rajabi, M., Sharif, A., Ardakani, A. T., Raygan, F., Assareh, A. A., & Sharif, M. R. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03954-z · Cited by 10 · see citing works
Rezaei, S. M. A., Mohammadi, F., Eftekhari, M. H., Ejtehadi, F., Ghaem, H., & Mohammadipoor, N. (2023) · BMC Nutrition · doi:10.1186/s40795-023-00776-z · Cited by 9 · see citing works
Tight Junction Proteins as Therapeutic Targets to Treat Liver Fibrosis and Hepatocellular Carcinoma
Saviano, A., Roehlen, N., & Baumert, T. F. (2024) · Seminars in Liver Disease · doi:10.1055/s-0044-1785646 · Cited by 9 · see citing works
Flagged first, then by citations
7 of the 89 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371 · see citing works
Han, H., Yu, D., Liu, Y., Jia, H., & Liu, W. (2025) · Science Advances · doi:10.1126/sciadv.adz4126 · Cited by 7 · see citing works
“Simultaneously, the metal ion–based loading of proteases effectively addressed the challenge of insufficient enzyme activity in the lesion area due to the depletion of metal ions (such as zinc ions) ( 45 , 46 ).”
Xie, S., Liu, M., Chen, L., Xie, Y., Liu, L., Chen, W., & Huang, H. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1690067 · Cited by 4 · see citing works
Zhang, Q., Dai, H., Bu, C., Gao, Z., Hou, C., & Chen, S. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.120442 · Cited by 3 · see citing works
Mitochondrial dysfunction and aging
Goel, F., & Tripathi, P. N. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-36295-8.00017-1 · Cited by 3 · see citing works
Roles of zinc in the gut-liver axis
Grüngreiff, K., Reinhold, D., & Maret, W. (2026) · Annals of Hepatology · doi:10.1016/j.aohep.2026.102188 · Cited by 3 · see citing works
Xue, W., Qu, Y., Ma, S., Li, Z., Lyu, S., Diao, X., Sun, K., Wang, Z., & Sun, R. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108589 · Cited by 3 · see citing works
Fujisawa, T., Takenaka, S., Maekawa, L., Ogawa, M., Kowada, T., Matsui, T., Mizukami, S., Kato, Y., Suzuki, M., Noma, H., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69476-z · Cited by 2 · see citing works
Lin, Y., & Wang, Y. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117906 · Cited by 1 · see citing works
Lipid metabolism in liver transplantation: from challenge to chance
Zhang, Y., Rui, W., Liu, X., Ya, Y., Pu, S., Zong, K., Yang, E., Li, S., Huang, Z., & Wu, Z. (2025) · Metabolism and Target Organ Damage · doi:10.20517/mtod.2025.03 · Cited by 1 · see citing works
GPR39-mediated molecular signaling by bile acids
Huang, Y., Zi, Z., Xia, C., & Rao, Y. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111241
Renal-Targeted Inulin-Based Gd/Zn Hybrids for Safe MRI Contrast and Early Fibrosis Mitigation
Wang, D., Zhang, W., Chen, L., Mai, Y., Wang, H., Miao, Z., & Zhao, Y. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s564432
High-Altitude Condition Induces Hepatic Magnetic Susceptibility Changes and Liver Injury
Zhou, X., Feng, C., Fu, J., Zhang, L., Song, C., Wang, J., Chen, L., & Zhang, X. (2026) · Biomolecules · doi:10.3390/biom16030353
Zinc, type 2 diabetes, diabetic kidney disease: focus on hypoxia
Лебедева, С. А., Михайлова, Е. М., Materenchuk, M. Y., Kurkin, D. V., Samsonov, M. Y., Tarasov, V. V., & Mutig, K. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1825409
Xu, Y., Jin, S., Hou, J., Guo, Y., Zhang, P., Xie, H., Peng, D., Zhao, Q., Lv, W., & Han, L. (2026) · International Journal of Pharmacology · doi:10.31083/ijp49475
Huang, R.-C., Zhu, G.-X., Tian, L.-G., Liu, X.-H., Cui, Y.-L., Zhang, Z.-Q., Xiang, M., Chen, Y., Yang, H., Gu, C., et al. (2026) · Environmental Pollution · doi:10.1016/j.envpol.2026.129248
- Authors
- Shendge, A. K., Sekler, I., & Hershfinkel, M.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Corresponding author
- Shendge, Anil Khushalrao
- Hershfinkel, Michal
- Venue
- Redox Biology
- Publisher
- Elsevier BV
- Published
- 2024-12
- Volume
- 78
- Pages
- 103403
- ISSN
- 2213-2317 (ISSN-L)
- PMC
- PMC11584770
- OpenAlex
- W4403522674
- Cited by
- 16
- References
- 89
- Citations by year
- 2026: 8 · 2025: 8
- FWCI
- 4.28
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Redox Biology (publishedVersion, cc-by-nc-nd)
- SSRN Electronic Journal (acceptedVersion)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Israel Science Foundation
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Keywords
- zinc signaling, hepatic insulin signaling, insulin receptor, ERK1/2 phosphorylation, Akt activation, liver fibrosis, liver injury, reactive oxygen species, oxygen consumption rate, hepatic lipid accumulation, liver inflammation, macrophage infiltration, lipopolysaccharide-induced liver injury, non-alcoholic fatty liver disease, zinc deficiency
- MeSH terms
- Animals, Energy Metabolism, Insulin, Liver, Liver Cirrhosis, Male, Signal Transduction, Reactive Oxygen Species, Mice, Knockout, Hepatocytes, Receptors, G-Protein-Coupled, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
