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Cited by 256

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers

Open access
Guerrero-Bosagna, Carlos, Covert, Trevor R., Haque, Md. M., Settles, Matthew, Nilsson, Eric E., Anway, Matthew D., Skinner, Michael K.·2012·Reproductive Toxicology
DOI 10.1016/j.reprotox.2012.09.005
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Abstract

The endocrine disruptor vinclozolin has previously been shown to promote epigenetic transgenerational inheritance of adult onset disease in the rat. The current study was designed to investigate the transgenerational actions of vinclozolin on the mouse. Transient exposure of the F0 generation gestating female during gonadal sex determination promoted transgenerational adult onset disease in F3 generation male and female mice, including spermatogenic cell defects, testicular abnormalities, prostate abnormalities, kidney abnormalities and polycystic ovarian disease. Pathology analysis demonstrated 75% of the vinclozolin lineage animals developed disease with 34% having two or more different disease states. Interestingly, the vinclozolin induced transgenerational disease was observed in the outbred CD-1 strain, but not the inbred 129 mouse strain. Analysis of the F3 generation sperm epigenome identified differential DNA methylation regions that can potentially be utilized as epigenetic biomarkers for transgenerational exposure and disease.

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Metadata

Authors
Guerrero-Bosagna, C., Covert, T. R., Haque, M. M., Settles, M., Nilsson, E. E., Anway, M. D., & Skinner, M. K.
Venue
Reproductive Toxicology
Publisher
Elsevier BV
Published
2012-12
Volume
34
Issue
4
Pages
694-707
ISSN
0890-6238 (ISSN-L)
DOI
10.1016/j.reprotox.2012.09.005
OpenAlex
W2034871574
Cited by
256
References
6
FWCI
15.94
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers. https://app.cochat.ai/papers/10.1016/j.reprotox.2012.09.005
The paper
Guerrero-Bosagna, C., Covert, T. R., Haque, M. M., Settles, M., Nilsson, E. E., Anway, M. D., & Skinner, M. K. (2012). Epigenetic transgenerational inheritance of vinclozolin induced mouse adult onset disease and associated sperm epigenome biomarkers. Reproductive Toxicology. https://doi.org/10.1016/j.reprotox.2012.09.005

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.