Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans
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Chromatin modifiers regulate lifespan in several organisms, raising the question of whether changes in chromatin states in the parental generation could be incompletely reprogrammed in the next generation and thereby affect the lifespan of descendants. The histone H3 lysine 4 trimethylation (H3K4me3) complex, composed of ASH-2, WDR-5 and the histone methyltransferase SET-2, regulates Caenorhabditis elegans lifespan. Here we show that deficiencies in the H3K4me3 chromatin modifiers ASH-2, WDR-5 or SET-2 in the parental generation extend the lifespan of descendants up until the third generation. The transgenerational inheritance of lifespan extension by members of the ASH-2 complex is dependent on the H3K4me3 demethylase RBR-2, and requires the presence of a functioning germline in the descendants. Transgenerational inheritance of lifespan is specific for the H3K4me3 methylation complex and is associated with epigenetic changes in gene expression. Thus, manipulation of specific chromatin modifiers only in parents can induce an epigenetic memory of longevity in descendants.
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Wild-type offspring of ASH-2 mutants can inherit a longevity memory for as many as four generations.
“Interestingly, a ‘longevity memory’ of ASH-2 mutant parents is observed in homozygous wild-type offspring for up four generations174.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [174]
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- Authors
- Greer, E. L., Maures, T. J., Ucar, D., Hauswirth, A. G., Mancini, E., Lim, J. P., Benayoun, B. A., Shi, Y., & Brunet, A.
- Affiliations
- Stanford University (US)
- Harvard University (US)
- Corresponding author
- Brunet, Anne
- ORCID
- Venue
- Nature
- Published
- 2011-10-19
- Volume
- 479
- Issue
- 7373
- Pages
- 365-371
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC3368121
- OpenAlex
- W2095102047
- Cited by
- 660
- References
- 57
- Citations by year
- 2026: 16 · 2025: 31 · 2024: 20 · 2023: 61 · 2022: 29 · 2021: 40 · 2020: 33 · 2019: 53 · 2018: 47 · 2017: 38 · 2016: 52 · 2015: 44 · 2014: 57 · 2013: 69 · 2012: 63
- FWCI
- 22.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- National Science Foundation
- Glenn Foundation for Medical Research
- National Institutes of Health
- National Institute on Aging (R56AG031198, ARRA-AG31198, F32AG037254, R01-AG31198, R01AG031198)
- National Institute of Mental Health (T32MH020016)
- National Cancer Institute (T32CA009361, T32CA009302)
- National Institute of General Medical Sciences (R01GM058012)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- transgenerational epigenetic inheritance, longevity, lifespan extension, H3K4me3, histone demethylation, chromatin modifiers, germline, Caenorhabditis elegans, epigenetic memory
- MeSH terms
- Animals, Chromatin, Female, Gene Expression Regulation, Histones, Longevity, Male, Methylation, Mutation, Nuclear Proteins, Pedigree, Histone-Lysine N-Methyltransferase, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Inheritance Patterns, Epigenesis, Genetic, Gene Knockdown Techniques, Histone Demethylases, Retinoblastoma-Binding Protein 2
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