The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
The Impact of Nutrition and Environmental Epigenetics on Human Health and Disease
Open accessAbstract
Environmental epigenetics describes how environmental factors affect cellular epigenetics and, hence, human health. Epigenetic marks alter the spatial conformation of chromatin to regulate gene expression. Environmental factors with epigenetic effects include behaviors, nutrition, and chemicals and industrial pollutants. Epigenetic mechanisms are also implicated during development in utero and at the cellular level, so environmental exposures may harm the fetus by impairing the epigenome of the developing organism to modify disease risk later in life. By contrast, bioactive food components may trigger protective epigenetic modifications throughout life, with early life nutrition being particularly important. Beyond their genetics, the overall health status of an individual may be regarded as an integration of many environmental signals starting at gestation and acting through epigenetic modifications. This review explores how the environment affects the epigenome in health and disease, with a particular focus on cancer. Understanding the molecular effects of behavior, nutrients, and pollutants might be relevant for developing preventative strategies and personalized heath programs. Furthermore, by restoring cellular differentiation, epigenetic drugs could represent a potential strategy for the treatment of many diseases including cancer.
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Cited by
Griñán-Ferré, C., Bellver-Sanchis, A., Izquierdo, V., Corpas, R., Roig-Soriano, J., Chillón, M., Andres-Lacueva, C., Somogyvári, M., Sőti, C., Sanfeliu, C., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101271 · Cited by 208
Praegnatio Perturbatio—Impact of Endocrine-Disrupting Chemicals
Padmanabhan, V., Song, W., & Puttabyatappa, M. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa035 · Cited by 103
ASMBS position statement on preoperative patient optimization before metabolic and bariatric surgery
Carter, J., Chang, J., Birriel, T. J., Moustarah, F., Sogg, S., Goodpaster, K., Benson-Davies, S., Chapmon, K., & Eisenberg, D. (2021) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2021.08.024 · Cited by 86
Li, Y., Guo, L.-L., He, K., Huang, C., & Tang, S. (2021) · Journal of Cancer · doi:10.7150/jca.51322 · Cited by 70
Understanding asthma and allergies by the lens of biodiversity and epigenetic changes
Fiuza, B. S. D., Fonseca, H. F., Meirelles, P. M., Marques, C. R., da Silva, T. M., & Figueiredo, C. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.623737 · Cited by 38
Metadata
- Authors
- Tiffon, C.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2018-11-01
- Volume
- 19
- Issue
- 11
- Pages
- 3425
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W2899197098
- Cited by
- 499
- References
- 95
- FWCI
- 10.59
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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