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Cited by 96Origins and Evolution of LifeLipid Membrane Structure and BehaviorRNA and protein synthesis mechanisms

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Self-assembly and function of primitive cell membranes

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Pohorille, Andrew, Deamer, David·2009·Research in Microbiology
DOI 10.1016/j.resmic.2009.06.004
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Abstract

We describe possible pathways for separating amphiphilic molecules from organic material on the early earth to form membrane-bound structures required for the start of cellular life. We review properties of the first membranes and their function as permeability barriers. Finally, we discuss the emergence of protein-mediated ion transport across membranes, which facilitated many other cellular functions.

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  • Lipids in solution form vesicles spontaneously because of their amphiphilic nature; they have one hydrophobic end and one hydrophilic end.

    “Lipids in solution form vesicles spontaneously because of their amphiphilic nature; that is, they have one hydrophobic end and one hydrophilic end (Pohorille and Deamer, 2009).”

    From The Astrobiology Primer v2.0 (2016) · cites this paper as Pohorille and Deamer, 2009

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Research works printed but not linked: 52

  1. Bangham, 1964, Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope, J. Mol. Biol., 8, 660, 10.1016/S0022-2836(64)80115-7 · DOI
  2. Bar, 1966, Surface area of human erythrocyte lipids: reinvestigation of experiments on plasma membrane, Science, 153, 1010, 10.1126/science.153.3739.1010 · DOI
  3. Blondelle, 1995, Induced conformational states of amphipathic peptides in aqueous/lipid environments, Biophys. J., 68, 351, 10.1016/S0006-3495(95)80194-3 · DOI
  4. Chakrabarti, 1992, Permeability of lipid bilayers to amino acids and phosphate, Biochim. Biophys. Acta, 1992, 171, 10.1016/0005-2736(92)90308-9 · DOI · Paper page
  5. Chizhmakov, 1996, Selective proton permeability and pH regulation of the influenza virus M2 channel expressed in mouse erythroleukaemia cells, J. Physiol., 494, 329, 10.1113/jphysiol.1996.sp021495 · DOI
  6. Cornut, 1996, In situ study by polarization modulated Fourier transform infrared spectroscopy of the structure and orientation of lipids and amphipathic peptides at the air–water interface, Biophys. J., 70, 305, 10.1016/S0006-3495(96)79571-1 · DOI
  7. Chyba, 1992, Endogenous production, exogenous delivery and impact-shock synthesis of organic molecules: an inventory for the origins of life, Nature, 355, 125, 10.1038/355125a0 · DOI · Paper page
  8. Davson, 1936, Studies on the permeability of erythrocytes: the alleged reversal of ionic permeability at alkaline reaction, Biochem. J., 30, 316, 10.1042/bj0300316 · DOI
  9. Deamer, 1997, The first living systems: a bioenergetic perspective, Microbiol. Mol. Biol. Rev., 61, 239
  10. Deamer, 1986, Permeability of lipid bilayers to water and ionic solutes, Chem. Phys. Lipids, 40, 167, 10.1016/0009-3084(86)90069-1 · DOI
  11. Duclohier, 2004, Conductance studies on trichotoxin_A50E and implications for channel structure, Biophys. J., 87, 1705, 10.1529/biophysj.104.040659 · DOI
  12. Duclohier, 1998, Antiamoebin can function as a carrier or as a pore-forming peptaibol, Biochim. Biophys. Acta, 1415, 255, 10.1016/S0005-2736(98)00184-9 · DOI
  13. Duff, 1992, The transmembrane domain of influenza A M2 protein forms amantadine-sensitive proton channels in planar lipid bilayer, Virology, 190, 485, 10.1016/0042-6822(92)91239-Q · DOI
  14. Epand, 1999, Diversity of antimicrobial peptides and their mechanisms of action, Biochim. Biophys. Acta, 1462, 11, 10.1016/S0005-2736(99)00198-4 · DOI
  15. Failli, 1979, The synthesis of cyclic peptides by the four component condensation (4Cc), Can. J. Chem., 57, 3257, 10.1139/v79-533 · DOI
  16. Gilbert, 1986, The RNA World, Nature, 319, 618, 10.1038/319618a0 · DOI · Paper page
  17. Gorter, 1925, On bimolecular layers of lipoids on the chromocytes of the blood, J. Exptl. Med., 41, 439, 10.1084/jem.41.4.439 · DOI
  18. Gutknecht, 1987, Proton conductance through phospholipid bilayers: water wires or weak acids?, J. Bioenerg. Biomembr., 19, 427, 10.1007/BF00770028 · DOI
  19. Hauser, 1973, Mechanism of ion escape from phosphatidylcholine and phosphatidylserine single bilayer vesicles, Biochemistry, 12, 4507, 10.1021/bi00746a032 · DOI
  20. Hargreaves, 1978, Liposomes from ionic, single-chain amphiphiles, Biochemistry, 17, 3759, 10.1021/bi00611a014 · DOI
  21. Hargreaves, 1977, Synthesis of phospholipids and membranes in prebiotic conditions, Nature, 266, 78, 10.1038/266078a0 · DOI
  22. Hladky, 1972, Ion transfer across lipid membranes in the presence of gramicidin A.I. Studies of the unit conductance channel, Biochim. Biophys. Acta, 274, 294, 10.1016/0005-2736(72)90178-2 · DOI
  23. Johnson, 1969, Potassium permeability of single compartment liposomes with and without valinomycin, Biochim. Biophys. Acta, 193, 82, 10.1016/0005-2736(69)90061-3 · DOI
  24. Kaiser, 1987, Peptides with affinity for membranes, Annu. Rev. Biophys. Biophys. Chem., 16, 561, 10.1146/annurev.bb.16.060187.003021 · DOI
  25. Lear, 2003, Proton conduction through the M2 protein of the in£uenza A virus; a quantitative, mechanistic analysis of experimental data, FEBS Lett., 552, 17, 10.1016/S0014-5793(03)00778-6 · DOI
  26. Lear, 1997, Electrostatic effects on ion selectivity and rectification in designed ion channel peptides, J. Am. Chem. Soc., 119, 3212, 10.1021/ja9629672 · DOI
  27. Lear, 1988, Synthetic amphiphilic peptide models for protein ion channels, Science, 240, 1177, 10.1126/science.2453923 · DOI
  28. Mezei, 1981, Monte Carlo studies of the structure of dilute aqueous solutions of Li+, Na+, K+, F−, and Cl−, J. Chem. Phys., 74, 6902, 10.1063/1.441101 · DOI
  29. Michalik, 2007, One-step synthesis of natural product-inspired biaryl ether-cyclopeptoid macrocycles by double ugi multiple-component reactions of bifunctional building blocks, Eur. J. Org. Chem., 2007, 149, 10.1002/ejoc.200600354 · DOI
  30. Milov, 2003, Self-assembling and membrane modifying properties of a lipopeptaibol studied by CW-ESR and PELDOR spectroscopies, J. Peptide Sci., 9, 690, 10.1002/psc.513 · DOI
  31. Monnard, 2007, Models of primitive cellular life: polymerases and templates in liposomes, Philos. Trans. R. Soc. Lond. B Biol. Sci., 362, 1741, 10.1098/rstb.2007.2066 · DOI
  32. Mueller, 1962, Reconstitution of excitable cell membrane structure in vitro, Circulation, 26, 1167, 10.1161/01.CIR.26.5.1167 · DOI
  33. Nagle, 1978, Molecular mechanisms for proton transport in membranes, Proc. Natl. Acad. Sci. U.S.A., 75, 298, 10.1073/pnas.75.1.298 · DOI
  34. Nagle, 1978, Lateral compressibility of lipid mono- and bilayers. Theory of membrane permeability, Biochim. Biophys. Acta, 513, 236, 10.1016/0005-2736(78)90176-1 · DOI
  35. Nagle, 1983, Hydrogen bonded chain mechanisms for proton conduction and proton pumping, J. Membr. Biol., 74, 1, 10.1007/BF01870590 · DOI
  36. Neumcke, 1969, Nonlinear electrical effects in lipid bilayer membranes. II. Integration of the generalized Nernst–Planck equations, Biophys. J., 9, 1160, 10.1016/S0006-3495(69)86443-X · DOI
  37. Nichols, 1980, Net proton-hydroxyl permeability of large unilamellar liposomes measured by an acid-base titration technique, Proc. Natl. Acad. Sci. USA, 77, 2038, 10.1073/pnas.77.4.2038 · DOI
  38. Nooner, 1976, Closed system Fischer–Tropsch synthesis over meteoritic iron, iron ore and nickel-iron alloy, Geochim. Cosmochim. Acta, 40, 915, 10.1016/0016-7037(76)90140-X · DOI
  39. Nozaki, 1981, Proton and hydroxide ion permeability of phospholipid vesicles, Proc. Natl. Acad. Sci. U.S.A., 78, 4324, 10.1073/pnas.78.7.4324 · DOI
  40. Pohorille, 2005, The origin and early evolution of membrane channels, Astrobiology, 5, 1, 10.1089/ast.2005.5.1 · DOI
  41. Pohorille, 1997, Interaction of alcohols and anesthetics with the water–hexane interface: a molecular dynamics study, Prog. Colloid Polym. Sci., 103, 29, 10.1007/3-798-51084-9_4 · DOI
  42. Pohorille, 2003, Membrane peptides and their role in protobiological evolution, Orig. Life Evol. Biosphere, 33, 173, 10.1023/A:1024627726231 · DOI
  43. Robertson, 1959, The ultrastructure of cell membranes and their derivatives, Biochem. Soc. Symp., 16, 3
  44. Simoneit, 2007, Abiotic formation of acylglycerols under simulated hydrothermal conditions and self-assembly properties of such lipid products, Adv. Space Res., 40, 1649, 10.1016/j.asr.2007.07.034 · DOI
  45. Singer, 1972, The fluid mosaic model of the structure of cell membranes, Science, 175, 720, 10.1126/science.175.4023.720 · DOI
  46. Stouffer, 2008, Structural basis for the function and inhibition of an influenza virus proton channel, Nature, 451, 596, 10.1038/nature06528 · DOI
  47. Szostak, 2001, Synthesizing life, Nature, 409, 387, 10.1038/35053176 · DOI · Paper page
  48. Tang, 2002, The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue, J. Biol. Chem., 277, 39880, 10.1074/jbc.M206582200 · DOI
  49. Vlassov, 2005, How was membrane permeability produced in an RNA world?, Orig. Life Evol. Biosphere, 35, 135, 10.1007/s11084-005-8901-9 · DOI
  50. Walde, 1994, Autopoietic self-reproduction of fatty acid vesicles, J. Am. Chem. Soc., 116, 11649, 10.1021/ja00105a004 · DOI · Paper page
  51. Wang, 1995, Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue, Biophys. J., 69, 1363, 10.1016/S0006-3495(95)80003-2 · DOI
  52. Wilson, 1996, Mechanism of unassisted ion transport across membrane bilayers, J. Am. Chem. Soc., 118, 6580, 10.1021/ja9540381 · DOI

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Metadata

Authors
Pohorille, A., & Deamer, D.
Affiliations
  • Ames Research Center (US)
  • University of California, Santa Cruz (US)
Corresponding author
Pohorille, Andrew
ORCID
Venue
Research in Microbiology
Publisher
Elsevier BV
Published
2009-09
Volume
160
Issue
7
Pages
449-456
ISSN
  • 0769-2609 (ISSN-L)
  • 0923-2508
DOI
10.1016/j.resmic.2009.06.004
OpenAlex
W2058474241
Cited by
96
References
9
Citations by year
2026: 3 · 2025: 2 · 2024: 11 · 2023: 9 · 2022: 4 · 2021: 5 · 2020: 9 · 2019: 4 · 2018: 7 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 10 · 2013: 6 · 2012: 7
FWCI
0.38
Type
journal article
Language
en
Open access
Licence
Locations
  • Research in Microbiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Aeronautics and Space Administration
Topics
  • Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords
self-assembly, origin of life, early Earth, amphiphilic molecules, membrane permeability barrier
MeSH terms
Cell Membrane, Cell Membrane Permeability, Biological Evolution, Models, Biological, Models, Molecular, Ion Transport

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