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COSCA (Core Outcome Set for Cardiac Arrest) in Adults: An Advisory Statement From the International Liaison Committee on Resuscitation
Open accessAbstract
Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on survival. A lack of consistency in outcome reporting between trials limits the opportunities to pool results for meta-analysis. The COSCA initiative (Core Outcome Set for Cardiac Arrest), a partnership between patients, their partners, clinicians, research scientists, and the International Liaison Committee on Resuscitation, sought to develop a consensus core outcome set for cardiac arrest for effectiveness trials. Core outcome sets are primarily intended for large, randomised clinical effectiveness trials (sometimes referred to as pragmatic trials or phase III/IV trials) rather than for pilot or efficacy studies. A systematic review of the literature combined with qualitative interviews among cardiac arrest survivors was used to generate a list of potential outcome domains. This list was prioritised through a Delphi process, which involved clinicians, patients, and their relatives/partners. An international advisory panel narrowed these down to 3 core domains by debate that led to consensus. The writing group refined recommendations for when these outcomes should be measured and further characterised relevant measurement tools. Consensus emerged that a core outcome set for reporting on effectiveness studies of cardiac arrest (COSCA) in adults should include survival, neurological function, and health-related quality of life. This should be reported as survival status and modified Rankin scale score at hospital discharge, at 30 days, or both. Health-related quality of life should be measured with ≥1 tools from Health Utilities Index version 3, Short-Form 36-Item Health Survey, and EuroQol 5D-5L at 90 days and at periodic intervals up to 1 year after cardiac arrest, if resources allow. © 2018 European Resuscitation Council and American Heart Association, Inc. Published by Elsevier B.V. All rights reserved.
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“The prognosis after cardiac arrest remains poor. 314 316”
From European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions (2021) · cites this paper as [314]
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Nolan, J. P., Sandroni, C., Böttiger, B. W., Cariou, A., Cronberg, T., Friberg, H., Genbrugge, C., Haywood, K. L., Lilja, G., Moulaert, V. R. M., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06368-4 · Cited by 1,132
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Metadata
- Authors
- Haywood, K., Whitehead, L., Nadkarni, V. M., Achana, F., Beesems, S., Böttiger, B. W., Brooks, A., Castrén, M., Ong, M. E. H., Hazinski, M. F., Koster, R. W., Lilja, G., Long, J., Monsieurs, K. G., Morley, P. T., Morrison, L., Nichol, G., Oriolo, V., Saposnik, G., Smyth, M., Spearpoint, K., Williams, B., & Perkins, G. D.
- ORCID
- Venue
- Resuscitation
- Publisher
- Elsevier BV
- Published
- 2018-06
- Volume
- 127
- Pages
- 147-163
- ISSN
- 0300-9572 (ISSN-L)
- OpenAlex
- W2985292347
- Cited by
- 227
- References
- 105
- Citations by year
- 2026: 21 · 2025: 23 · 2024: 24 · 2023: 21 · 2022: 13 · 2021: 53 · 2020: 32 · 2019: 29 · 2018: 9
- FWCI
- 37.92
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Resuscitation (publishedVersion)
- Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Työväentutkimus Vuosikirja (submittedVersion, other-oa)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Social Sciences › Sociology and Political Science › Delphi Technique in Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Keywords
- cardiac arrest, core outcome set, outcome reporting, effectiveness trials, neurological function, health-related quality of life, survival, modified Rankin Scale, Health Utilities Index 3, SF-36, EQ-5D-5L, consensus development, International Liaison Committee on Resuscitation, cardiac arrest survivors
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