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Cited by 29Wound Healing and TreatmentsDiabetic Foot Ulcer Assessment and ManagementElectrospun Nanofibers in Biomedical Applications

Novel design and development of Centella Asiatica extract - loaded poloxamer/ZnO nanocomposite wound closure material to improve anti-bacterial action and enhanced wound healing efficacy in diabetic foot ulcer

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Wang, Lina, Yang, Yan, Han, Weiwei, Ding, Hui·2024·Regenerative Therapy
DOI 10.1016/j.reth.2024.03.006PMC PMC10963185
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Abstract

Diabetic wounds can occur as a prevalent complication among people diagnosed with diabetes, frequently resulting in the necessity for amputation. The cause and effect of diabetic foot ulcer is complex, involving multiple factors. In the present study, wound healing strategies utilizing nanomaterials have proven to be effective in battling bacterial infections and improve wound regeneration. Poloxamers (PLX) exhibit extensive potential as a viable option for the development of nanomedicines owing to their inherent characteristics of self-assembly and encapsulation. This study aims to design and develop a PLX/ZnO nanocomposite incorporated with Centella Asiatica extract (CAE) for the multi-functional action in the diabetic wound healing treatment. Subsequently physico-chemical characterizations, such as XRD, FTIR, and TEM observations, demonstrated that the ZnO were evenly distributed through the PLX framework. The developed nanocomposite was biocompatible with mouse fibroblast cell line (L929), and it had multiple beneficial characteristics, such as a rapid self-healing process and effective antibacterial action against G+ and G− bacterial pathogens. After being treated with the developed formulation, skin fibroblast cell line and HUVECs demonstrated a substantial increase in their in vitro cell proliferation ability, migration, and tube-forming abilities. The utilization of a CAE@PLX/ZnO nanoformulation presents a viable strategy and a distinctive, encouraging composite for diabetic wound healing treatment.

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  • Nanocomposites utilizing inorganic matrices such as porous silica or metal oxides are increasingly used to stabilize C. asiatica compounds and enable targeted dermal effects.

    “Nanocomposites utilizing inorganic matrices such as porous silica or metal oxides are increasingly used to stabilize C. asiatica compounds and enable targeted dermal effects.”

    From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Wang et al. 2024

    The Introduction (page unavailable) describes a Centella asiatica extract–loaded poloxamer/ZnO nanocomposite intended for diabetic wound healing, and the Results and discussion report improved fibroblast proliferation. The paper does not describe porous silica or establish increasing use of these composites. It attributes the formulation’s expected stabilizing effect to poloxamer, not specifically to an inorganic matrix stabilizing Centella compounds. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • Formulations with ZnO or magnetic oxides demonstrated antimicrobial, antioxidant, and angiogenic effects in diabetic wound and fungal models.

    “Similar formulations with ZnO or magnetic oxides demonstrated antimicrobial, antioxidant, and angiogenic effects in diabetic wound and fungal models (Wang et al. 2024; Sahara et al. 2025).”

    From Centella asiatica (L.) Urb. in skin health and cosmeceuticals: mechanisms, clinical evidence, and advanced delivery systems (2025) · cites this paper as Wang et al. 2024

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References 37 · Cited by 29

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Authors
Wang, L., Yang, Y., Han, W., & Ding, H.
Corresponding author
Ding, Hui
ORCID
Venue
Regenerative Therapy
Publisher
Elsevier BV
Published
2024-12
Volume
27
Pages
92-103
ISSN
2352-3204 (ISSN-L)
DOI
10.1016/j.reth.2024.03.006
PMC
PMC10963185
OpenAlex
W4392914909
Cited by
29
References
37
Citations by year
2026: 7 · 2025: 14 · 2024: 8
FWCI
4.61
Type
journal article
Language
en
Open access
Licence
Locations
  • Regenerative Therapy (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Topics
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetic Foot Ulcer Assessment and Management
  • Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
Keywords
Centella asiatica extract, poloxamer, zinc oxide nanocomposites, diabetic foot ulcer, wound healing, antibacterial activity, self-healing hydrogels, nanomedicine, angiogenesis, cell proliferation, L929 fibroblasts, human umbilical vein endothelial cells

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