Novel fabrication of anti-VEGF drug ranibizumab loaded PLGA/PLA co-polymeric nanomicelles for long-acting intraocular delivery in the treatment of age-related macular degeneration therapy
Open accessAbstract
Age associated macular degeneration is the 3rd primary cause of blind fundus diseases globally. A reliable and long-lasting method of intraocular drug delivery is still needed. Herein, this study was aim to develop the novel fabrication of ranibizumab loaded co-polymeric nanomicelles (Rabz-CP-NMs) for AMD. The CMC of co-polymeric nanomicelles was determined to be low, at 6.2 μg/ml. The ring copolymerization method was employed to fabricate the NMs and characterize via FTIR, XRD, TEM, DLS and Zeta potential. Rabz-CP-NMs was spherical shape with 10-50 nm in size. Stable and prolonged drug release was achieved with the Rabz from CP-NMs at 48 h. D407 and ARPE19 ocular cell lines showed dose-dependent cell viability with Rabz-CP-NMs. The Rabz-CP-NMs also had less toxicity, higher uptake, lower cell death and prolonged VEGF-A inhibition, as shown by cytoviability assay. Thus, Rabz-CP-NMs were safe for ocular use, suggesting that could be used to improve intraocular AMD treatment.
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Rabz-CP-NMs is safe and applicable for intraocular administration, providing a new option for improving the treatment of AMD.
“It has been proved that Rabz-CP-NMs is safe and applicable for intraocular administration, providing a new option for improving the treatment of AMD [195].”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [195]
The Conclusion (page not provided) describes Rabz-CP-NMs as safe for ocular use and a potential candidate for improving intraocular AMD treatment. But the reported safety findings come from in-vitro ocular-cell tests; the paper presents intraocular use as a possibility, not as proven safe and applicable for administration. (LLM, conf=0.88)
Experimental — accuracy not yet measuredRabz-CP-NMs achieves long-acting drug release for 48 h in PBS at pH7.4.
“Rabz-CP NMs achieves long-acting drug release for 48 h in PBS at pH7.4.”
From From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics (2025) · cites this paper as [195]
The Results and discussion, ‘Drug release activity’ (page unavailable), reports slow release from Rabz-CP-NMs, with 23.7% released at 48 hours, and describes the results at pH 7.4. However, Materials and methods, ‘Drug release activity’ (page unavailable), specifies PBS at pH 7, not pH 7.4, so the claimed PBS condition is not consistently supported. (LLM, conf=0.85)
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Manchanda, N., Kaul, S., Mittal, S., & Talegaonkar, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33781-9.00017-4
- Authors
- Xu, J.-F., Wang, Y.-P., & Liu, X.-H.
- Affiliations
- Dongyang People's Hospital (CN)
- Corresponding author
- Liu, Xiao-hua
- ORCID
- Liu, Xiao-hua
- Venue
- Regenerative Therapy
- Publisher
- Elsevier BV
- Published
- 2024-06
- Volume
- 26
- Pages
- 620-634
- ISSN
- 2352-3204 (ISSN-L)
- PMC
- PMC11399609
- OpenAlex
- W4401908852
- Cited by
- 12
- References
- 81
- Citations by year
- 2026: 1 · 2025: 10 · 2024: 1
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Regenerative Therapy (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Keywords
- ranibizumab, age-related macular degeneration, nanomicelles, intraocular drug delivery, anti-VEGF therapy, VEGF-A inhibition, sustained drug release, ocular toxicity, ARPE-19 cells, ocular drug delivery
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