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A New Era in Ocular Therapeutics: Advanced Drug Delivery Systems for Uveitis and Neuro-Ophthalmologic Conditions

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Quality by Design-Optimized Glycerosome-Enabled Nanosunscreen Gel of Rutin Hydrate

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Development of Dexamethasone Loaded Nanomicelles Using a 3d Printed Microfluidic Device for Ocular Drug Delivery Applications

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Optimization and Characterization of Brimonidine Tartrate Nanoparticles-loaded In Situ Gel for the Treatment of Glaucoma

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Age-Related Macular Degeneration (AMD): Pathophysiology, Drug Targeting Approaches, and Recent Developments in Nanotherapeutics

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Pterostilbene-Loaded Soluplus/Poloxamer 188 Mixed Micelles for Protection against Acetaminophen-Induced Acute Liver Injury

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Optimization and Characterization of Low-Molecular-Weight Chitosan-Coated Baicalin mPEG-PLGA Nanoparticles for the Treatment of Cataract

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Micelles based on polyvinylpyrrolidone VA64: A potential nanoplatform for the ocular delivery of apocynin

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Research progress of ophthalmic preparations of immunosuppressants

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Fenofibrate loaded nanofibers based thermo-responsive gel for ocular delivery: Formulation development, characterization and in vitro toxicity study

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Recent Advances in Studying In Vitro Drug Permeation Across Mucosal Membranes

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Novel fabrication of anti-VEGF drug ranibizumab loaded PLGA/PLA co-polymeric nanomicelles for long-acting intraocular delivery in the treatment of age-related macular degeneration therapy

Xu, J.-F., Wang, Y.-P., & Liu, X.-H. (2024) · Regenerative Therapy · doi:10.1016/j.reth.2024.06.019 · Cited by 12 · see citing works

Age-Related Macular Degeneration - Therapies and Their Delivery

Ponnusamy, C., Puratchikody, A., Selvamuthu, P., & Natesan, S. (2023) · Current Drug Delivery · doi:10.2174/1567201820666230510100742 · Cited by 12 · see citing works

Exploring the advancement of polymer-based nano-formulations for ocular drug delivery systems: an explicative review

Chakraborty, M., Banerjee, D., Mukherjee, S., & Karati, D. (2022) · Polymer Bulletin · doi:10.1007/s00289-022-04661-w · Cited by 12 · see citing works

10-Hydroxy Decanoic Acid-Based Vesicles as a Novel Topical Delivery System: Would It Be a Better Platform Than Conventional Oleic Acid Ufasomes for Skin Cancer Treatment?

Atef, B., Ishak, R. A. H., Badawy, S. S., & Osman, R. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15051461 · Cited by 12 · see citing works

Revamping the corneal permeability and antiglaucoma therapeutic potential of brinzolamide using transniosomes: optimization, in vitro and preclinical evaluation

Patil, R. K., Srivastava, V., Bhawale, R., Tryphena, K. P., Khatri, D. K., Doijad, N. S., & Mehra, N. K. (2024) · Nanomedicine · doi:10.2217/nnm-2023-0280 · Cited by 11 · see citing works

Drug delivery methods based on nanotechnology for the treatment of eye diseases

Khaled, M. T. O., Zaater, A., Amor, I. B., Zeghoud, S., Amor, A. B., Hemmami, H., & Alhamad, A. A. (2023) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000001399 · Cited by 11 · see citing works

Functionalization of polymeric nanomicelles and mixed nanomicelles for targeted retinal delivery in the management of retinoblastoma

Ansari, M., Gupta, C., Kulkarni, Y. A., & Singh, K. (2025) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2025.125235 · Cited by 10 · see citing works

Targeted Nanotherapies for the Posterior Segment of the Eye: An Integrative Review on Recent Advancements and Challenges

Gogoi, N. R., Marbaniang, D., Pal, P., Ray, S., & Mazumder, B. (2022) · Pharmaceutical Nanotechnology · doi:10.2174/2211738510666220806102612 · Cited by 10 · see citing works

A simple but novel glycymicelle ophthalmic solution based on two approved drugs empagliflozin and glycyrrhizin: in vitro / in vivo experimental evaluation for the treatment of corneal alkali burns

Sun, Z., Zhang, M., Wei, Y., Li, M., Wu, X., & Xin, M. (2023) · Biomaterials Science · doi:10.1039/d2bm01957d · Cited by 10 · see citing works

Breaking barriers in ocular drug delivery for Uveitis: Advanced drug delivery systems, challenges and future prospects

Ambekar, A., Sahoo, J., & Singh, K. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110456 · Cited by 9 · see citing works

Topical hydrophilic gel with itraconazole-loaded polymeric nanomicelles improves wound healing in the treatment of feline sporotrichosis

Santiago, M. G., da Silva, C. D., de Souza, B. M., Assis, B. R. D., Pinto, P. N., Keller, K. M., Vilela, R., de Oliveira, C. S. F., & Goulart, G. A. C. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122619 · Cited by 8 · see citing works

Novel Polyvinyl-Alcohol Microsphere for Everolimus Delivery for Subependymal Giant Cell Astrocytoma

Louis, L., Chee, B. S., Louis, N., de Lima, G. G., McAfee, M., Murphy, A., & Nugent, M. (2022) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104204 · Cited by 7 · see citing works

Posaconazole-hemp seed oil loaded nanomicelles for invasive fungal disease

Rathee, A. S., Solanki, P., Emad, N. A., Zai, I., Ahmad, S., Alam, S., Alqahtani, A. S., Noman, O. M., Kohli, K., & Sultana, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-66074-1 · Cited by 7 · see citing works

Stability enhancement of Amphotericin B using 3D printed biomimetic polymeric corneal patch to treat fungal infections

Kailasam, V., Hiremath, M. S., Pandiyan, S., Nagarjuna, V., Garg, P., & Nirmal, J. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.125149 · Cited by 7 · see citing works

From design to Deployment: The innovative role of nanomicelles in targeted ophthalmic therapeutics

Sun, M., Wang, J., Fan, W., Wang, K., Wang, Y., Zhang, J., Ding, S., Zhang, C., Feng, Z., Wang, Y.-G., et al. (2025) · Materials today. Bio · doi:10.1016/j.mtbio.2025.102537 · Cited by 7 · see citing works

Atorvastatin calcium formulation development followed by pharmacokinetic with in vitro and in vivo correlation (IVIVC) with employing soluplus and hydroxy propyl methyl cellulose with optimization

Ramarao, C. T., & Pavani, P. (2023) · Egyptian Pharmaceutical Journal · doi:10.4103/epj.epj_43_22 · Cited by 6 · see citing works

Carbohydrate Polymers, Polymeric Nano Drugs, and Nanoparticles Are Used for Advanced Drug Delivery and Therapeutics in Ocular Diseases

Hatamie, S., Shih, P., Chen, B., & Hatami, N. (2025) · Polymers for Advanced Technologies · doi:10.1002/pat.70094 · Cited by 6 · see citing works

Design, development and in vitro quantification of novel electrosprayed everolimus-loaded Soluplus®/Polyvinyl alcohol nanoparticles via stability-indicating HPLC method in cancer therapy

Louis, L., Chee, B. S., McAfee, M., & Nugent, M. (2023) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2023.09.008 · Cited by 6 · see citing works

Corneal targeted Amorolfine HCl-mixed micelles for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo assessments

Abd-Elmonem, E. M., Makky, A. M. A., Anter, A., Abd-Elsalam, W. H., & Khalil, I. A. H. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104614 · Cited by 6 · see citing works

Ocular polymeric nanomicelles for the posterior eye segment in the management of retinoblastoma: formulation, optimization, <i>in vitro</i> and <i>ex vivo</i> evaluations

Ansari, M., Kulkarni, Y. A., & Singh, K. (2025) · Pharmaceutical Development and Technology · doi:10.1080/10837450.2025.2469321 · Cited by 5 · see citing works

Novel composite fatty acid vesicles-in-Pluronic lecithin organogels for enhanced magnolol delivery in skin cancer treatment

Atef, B., Ishak, R. A. H., Badawy, S. S., & Osman, R. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114379 · Cited by 5 · see citing works

Revolutionizing uveitis treatment with nanotechnology: Innovations, barriers, and strategic solutions

Johari, M., Baghban, R., Salari, R., & Attar, A. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118911 · Cited by 5 · see citing works

Comparative Study of Dexamethasone-Loaded Thermoresponsive In Situ Gels and Polymeric Micelles for Ocular Drug Delivery

Szalai, B., Jójárt‐Laczkovich, O., Kovács, A., Berkó, S., Sipos, B., Katona, G., & Budai-Szűcs, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26178414 · Cited by 5 · see citing works

Recent Advancements and Patent Search on Polymeric Nanoparticles

Patnaik, A., Jena, G. K., & Patra, C. N. (2023) · BioNanoScience · doi:10.1007/s12668-023-01220-z · Cited by 5 · see citing works

Intranasal Radioiodinated Ferulic Acid Polymeric Micelles as the First Nuclear Medicine Imaging Probe for ETRA Brain Receptor

Fayez, H., Selim, A. A., Shamma, R. N., & Rashed, H. M. (2024) · Current Radiopharmaceuticals · doi:10.2174/0118744710269885231113070356 · Cited by 5 · see citing works

Highly effective inhalable voriconazole-loaded nanomicelles for fungal infections in cystic fibrosis patients: A promising therapeutic strategy for allergic bronchopulmonary aspergillosis

Briceño, V. F., Alava, K. H., Bernabeu, E., Fuentes, P., Devoto, T. B., Höcht, C., Chiappetta, D. A., Cuestas, M. L., & Moretton, M. A. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106126 · Cited by 5 · see citing works

Drug-like properties and topical delivery of rapalogs and tacrolimus in ophthalmology

Sigurðsson, H. H., Jansook, P., & Loftsson, Þ. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106207 · Cited by 4 · see citing works

Sustained Ocular Delivery of Moxifloxacin–Ufasomes-Laden In Situ Gel for Keratitis Management

El-Fadaly, G., Ghorab, D. M., Sorogy, H. M. E., Eldin, S. S., Sabet, M. A., & Teba, H. E. (2026) · Pharmaceuticals · doi:10.3390/ph19020313 · Cited by 4 · see citing works

Application of Box–Behnken design for the optimization of Plumbago zeylanica extract-loaded niosomes: preparation, characterization and in vitro antidiabetic and antioxidant activity

Tyagi, R., Waheed, A., Kumar, N., Ahad, A., Mujeeb, M., Naved, T., & Madan, S. (2023) · Journal of Dispersion Science and Technology · doi:10.1080/01932691.2023.2256387 · Cited by 4 · see citing works

Recent progress in polymeric micelle-Enabled targeted Nanotherapeutics for diabetic retinopathy

Sil, D., Kumar, D., Kurmi, B. D., & Kumar, M. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.106448 · Cited by 4 · see citing works

Optimization and evaluation of polymeric mixed nanomicelles for ocular delivery to the posterior eye segment

Ansari, M., Kulkarni, Y. A., & Singh, K. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106605 · Cited by 3 · see citing works

Hot Melt Extrusion-Triggered Amorphization as a Continuous Process for Inducing Extended Supersaturable Drug Immediate-Release from saSMSDs Systems

Yu, H., Zhang, Y., Ma, Y., Zhang, H., Hao, C., Zhang, Y., Li, Z., Qi, X., & Shi, N. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14040765 · Cited by 3 · see citing works

Advances in Ophthalmic Formulation Development

Bhawale, R., Srivastava, V., & Mehra, N. K. (2025) · Springer eBooks · doi:10.1007/978-981-97-9230-6_12 · Cited by 3 · see citing works

A Complete Appraisal of Polymeric Micelle-Based Nanocarrier for Targeting Breast Cancer: Recent Strategies and Advancements

Ray, S., & Singh, D. (2024) · Current Drug Therapy · doi:10.2174/0115748855302263240910060240 · Cited by 2 · see citing works

Fabrication and application of a dual drug-loaded nanoniosomes encapsulating rutin and berberine: optimization, in vitro and ex vivo evaluation

Tyagi, R., Sharma, V., Kumar, N., Kumar, S., Sahu, N., Arya, S., James, S., Naved, T., Alam, P., & Madan, S. (2024) · Journal of Dispersion Science and Technology · doi:10.1080/01932691.2024.2425951 · Cited by 1 · see citing works

A Paradigm Shift in Ocular Drug Delivery to Posterior Segment: Review on Current Drug Delivery Approaches

Koduru, R. K., Kasaraneni, J., & Juturi, R. K. R. (2021) · Journal of Pharmaceutical Research International · doi:10.9734/jpri/2021/v33i40a32226 · Cited by 1 · see citing works

Polymeric micellar nanocarriers: topical treatment of inflammatory diseases

Kahraman, E., Durgun, M. E., Güngör, S., & Özsoy, Y. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89868-3.00011-2

Lipid-based nanotherapeutic interventions for the treatment of ocular diseases

Narang, J. K., Kaur, K., Kaur, G., Dogra, A., & Pandita, D. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15264-1.00008-7

Advances in Controlled Release Formulations for Ocular Diseases: Improving Patient Compliance and Therapeutic Outcomes

Narwal, S., Dushyant, Singh, G., Grewal, N., Chanalia, V., & Dhingra, A. K. (2025) · Current Drug Metabolism · doi:10.2174/0113892002384586250731104453

Exploring the Therapeutic Potential of Apricot-Loaded Phytosomal Gel for Burn Wound Healing in Wistar Rats

Rajpurohit, M., Patil, M., & Khatib, N. A. (2025) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-025-10148-8

Combination of Solid Dispersion and Potential Iontophoresis for Improving Transcorneal In Vitro Permeation of Itraconazole

Das, S., Mohanty, B., Mishra, B., & Nayak, B. S. (2026) · Springer eBooks · doi:10.1007/978-3-032-12320-6_28

Enhanced topical delivery of terbinafine HCl nanomicelles embedded in chitosan gel for improved antifungal activity

Maryam, G.-E., Nasir, F., Gohar, S., Pervez, S., Hidayatullah, K., Khalil, H., Almalki, W. H., Khattak, M. A., Hidayatullah, T., Rehman, A. U., et al. (2026) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2026.2654741

Ocular topical aesculetin delivery via VA64/TPGS co-assembled micelles for redox-inflammatory modulation in selenite-induced cataract

Huang, X., Li, A., Wu, X., Wang, H., Tian, L., & Jie, Y. (2026) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2026.116101

Preparation and study of two kinds of ophthalmic nano-preparations of everolimus

Tang, Z., Yin, L., Zhang, Y., Yu, W.-Y., Wang, Q., & Zhan, Z. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1692966 · Cited by 32 · see citing works

Nanomicelle formulation for topical delivery of cyclosporine A into the cornea: in vitro mechanism and in vivo permeation evaluation

Guo, C., Zhang, Y., Yang, Z., Li, M., Li, F., Cui, F., Liu, T., Shi, W., & Wu, X. (2015) · Scientific Reports · doi:10.1038/srep12968 · Cited by 80 · see citing works

Topical application of polymeric nanomicelles in ophthalmology: a review on research efforts for the noninvasive delivery of ocular therapeutics

Grimaudo, M. A., Pescina, S., Padula, C., Santi, P., Concheiro, A., Alvarez-Lorenzo, C., & Nicoli, S. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1597848 · Cited by 78 · see citing works

New nanomicelle curcumin formulation for ocular delivery: Improved stability, solubility, and ocular anti-inflammatory treatment

Li, M., Xin, M., Guo, C., Lin, G., & Wu, X. (2017) · Drug Development and Industrial Pharmacy · doi:10.1080/03639045.2017.1349787 · Cited by 103 · see citing works

A novel FK506 loaded nanomicelles consisting of amino-terminated poly(ethylene glycol)-block-poly(D,L)-lactic acid and hydroxypropyl methylcellulose for ocular drug delivery

Liu, D., Wu, Q., Chen, W., Lin, H., Zhu, Y., Liu, Y., Liang, H., & Zhu, F. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.03.022 · Cited by 57 · see citing works