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Higher BMI is associated with worse asthma control and quality of life but not asthma severity
Open accessAbstract
Asthma and obesity tend to co-occur, but relatively few studies have linked obesity, measured using body mass index (BMI), to clinically relevant measures of asthma morbidity. This study assessed BMI in a Canadian sample of asthma outpatients, and evaluated associations between BMI and levels of asthma severity, asthma control, and asthma-related quality of life. A total of 382 adult asthma patients underwent demographic and medical history interviews on the day of their clinic visit. Patients' self-reported height and weight were used to calculate BMI (kg/m(2)). Asthma severity was classified according the GINA (2002) guidelines. Patients completed the Asthma Control (ACQ) and Asthma Quality of Life (AQLQ) Questionnaires and underwent standard pulmonary testing (spirometry). A total of 139 (36%) patients had a normal BMI; 149 (39%) patients were overweight; and 94 (25%) patients were obese. There was no relationship between BMI and asthma severity when controlling for age and sex. Patients with higher BMI scores had higher ACQ and lower AQLQ scores, independent of age, sex and asthma severity. Results identify higher BMI and obesity as potential behavioral factors related to worse asthma control and quality of life, but not asthma severity, and suggest important avenues for asthma management and control initiatives.
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“For instance, a higher proportion of people with asthma seem to have overweight or obese BMI67 and weight loss intervention studies have been associated with improvements in asthma symptoms.68”
From A systematic review of psychological, physical health factors, and quality of life in adult asthma (2019) · cites this paper as [67]
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“…actual differences in asthma severity between obese and normal weight individuals with asthma (e.g., Bibi et al., 2004), numerous studies of adults (Lavoie et al., 2006; Schachter et al., 2001; Sin et al., 2002; Thomson et al., 2003) and children (Belamarich et al., 2000; Bibi et al., 2004;…”
Ma, J., Strub, P., Camargo, C. A., Xiao, L., Ayala, E., Gardner, C. D., Buist, A. S., Haskell, W. L., Lavori, P. W., & Wilson, S. R. (2010) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-10-16 · Cited by 35
Noonan, C. W., Brown, B. D., Bentley, B., Conway, K., Corcoran, M., FourStar, K., Freide, P., Hemlock, B., Wagner, S., & Wilson, T. (2010) · Journal of Asthma · doi:10.3109/02770901003759436 · Cited by 34
Stridsman, C., Bäckman, H., Eklund, B., Rönmark, E., & Hedman, L. (2017) · Pediatric Pulmonology · doi:10.1002/ppul.23723 · Cited by 34
Key factors associated with uncontrolled asthma – the Asthma Control in Latin America Study
Neffen, H. E., Marco Chahuán, Y., Hernández, D. D., Vallejo-Perez, E., Bolívar, F., Sánchez, M. H., Galleguillos, F., Castaños, C., Silva, R. S., Giugno, E. R., et al. (2019) · Journal of Asthma · doi:10.1080/02770903.2018.1553050 · Cited by 36
“In the multivariate analysis, obesity was associated with worse disease control, which aligns with other studies in which higher BMI was found to be associated with poor asthma control [6,27,34].”
ResultGrammer, L. C., Weiss, K. B., Pedicano, J. B., Kimmel, L. G., Curtis, L. M., Catrambone, C. D., Lyttle, C. S., Sharp, L. K., & Sadowski, L. S. (2010) · Journal of Asthma · doi:10.3109/02770901003801980 · Cited by 33
Influence of obesity on the prevalence and clinical features of asthma
Boulet, L. (2008) · Clinical and investigative medicine · doi:10.25011/cim.v31i6.4926 · Cited by 33
Prevalence of obesity in asthma and its relations with asthma severity and control
Forte, G. C., Grutcki, D. M., Menegotto, S. M., Pereira, R. P., & Dalcin, P. D. T. R. (2013) · Revista da Associação Médica Brasileira · doi:10.1016/j.ramb.2013.06.015 · Cited by 31
Impact of body mass index on omalizumab response in adults with moderate-to-severe allergic asthma
Geng, B., Dixon, A. E., Ko, J., Janampally, P., Haselkorn, T., Holweg, C. T. J., Casale, T. B., & Jarjour, N. N. (2022) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2022.01.025 · Cited by 31
Metabolic shift favoring C18:0 ceramide accumulation in obese asthma
Choi, Y., Kim, M., Kim, S. J., Yoo, H., Kim, S., & Park, H. (2020) · Allergy · doi:10.1111/all.14366 · Cited by 30
Association between patterns of leisure time physical activity and asthma control in adult patients
Bacon, S., Lemière, C., Moullec, G., Ninot, G., Pepin, V., & Lavoie, K. (2015) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2015-000083 · Cited by 30
Self-citationSignificant predictors of poor quality of life in older asthmatics
Kannan, J. A., Bernstein, D. I., Bernstein, C. K., Ryan, P., Bernstein, J. A., Villareal, M. S., Smith, A. M., Lenz, P. H., & Epstein, T. G. (2015) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2015.06.021 · Cited by 28
Lombardi, C., Gargioni, S., Gardinazzi, A., Canonica, G. W., & Passalacqua, G. (2011) · Journal of Asthma · doi:10.3109/02770903.2011.587581 · Cited by 28
Diet effects in the asthma treatment: A systematic review
Forte, G. C., da Silva, D. T. R., Hennemann, M. L. T., Sarmento, R. A., de Almeida, J. C., & Dalcin, P. D. T. R. (2017) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2017.1289893 · Cited by 29
“© 2018 Taylor & Francis Group, LLC potential antioxidant effects tend to increase the prevalence of the disease and lead to deterioration of symptoms (Devereux and Seaton, 2005; Lavoie et al., 2006).”
BackgroundRoche, N., Plaza, V., Backer, V., van der Palen, J. A. M., Cerveri, I., Gonzalez, C., SAFIOTI, G. G., Scheepstra, I., Patino, O., & Singh, D. (2020) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-019-0159-1 · Cited by 27
Challenges in uncontrolled asthma in pediatrics: important considerations for the clinician
Andrenacci, B., Ferrante, G., Roberto, G., PIACENTINI, G. L., Grutta, S. L., Marseglia, G. L., & Licari, A. (2022) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2022.2093187 · Cited by 27
Health-related quality of life in childhood bronchial asthma
Al, M. S., El-Hosseiny, M., Elezz, N. F. A., El, D. H., & Hassan, A. M. (2013) · Cited by 27
Fitzgerald, M. P., Hennigan, K., O’Gorman, C. S., & McCarron, L. C. (2018) · Irish Journal of Medical Science (1971 -) · doi:10.1007/s11845-018-1814-1 · Cited by 33
Validation of the asthma impact survey, a brief asthma-specific quality of life tool
Schatz, M. N., Mosen, D. M., Kosinski, M. R., Vollmer, W. M., O’Connor, E., Cook, E. F., & Zeiger, R. S. (2006) · Quality of Life Research · doi:10.1007/s11136-006-9103-2 · Cited by 27
“Independent predictors of AIS-6 and AQLQ scores Oral corticosteroid use, a history of COPD, BMI, female sex, lower education, and a history of an asthma hospitalization in the past year were significant independent predictors of both the AIS-6 and AQLQ in this sample (Table 10).”
BackgroundInfluentialDragomir, A. I., Boucher, V. G., Bacon, S., Gemme, C., Szczepanik, G., Corace, K. M., Campbell, T. S., Vallis, M. T., Garber, G. E., Rouleau, C. R., et al. (2020) · Translational Behavioral Medicine · doi:10.1093/tbm/ibaa015 · Cited by 28
Self-citationAssociation of obesity with asthma severity, control and quality of life.
Maâlej, S., Yacoub, Z., Fakhfekh, R., Yaalaoui, S., Kheder, A. B., & Drira, I. (2012) · Europe PMC (PubMed Central) · Cited by 26
The treatment of asthma in obesity
Dixon, A. E. (2012) · Expert Review of Respiratory Medicine · doi:10.1586/ers.12.22 · Cited by 26
Weight loss interventions for chronic asthma
Adeniyi, F. B., & Young, T. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009339 · Cited by 26
Asthma in obese women: outcomes and factors involved.
Kilic, H., Oğuzülgen, I. K., Bakir, F., & Türktaş, H. (2011) · PubMed · Cited by 24
Immunometabolism in Obese Asthmatics: Are We There Yet?
Periyalil, H., Gibson, P. G., & Wood, L. G. (2013) · Nutrients · doi:10.3390/nu5093506 · Cited by 24
“and quality of life [9,176,189].”
Role of metalloproteinases and TNF-α in obesity-associated asthma in mice
Vieira, C. P., de Oliveira, L. P., da Silva, M. B., André, D. M., Tavares, E. B. G., Pimentel, E. R., & Antunes, E. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118191 · Cited by 23
Holguín, F., Rojas, M., & Hart, C. M. (2007) · Lung · doi:10.1007/s00408-007-9035-9 · Cited by 23
“In addition, conventional asthma therapy may not be as efficacious in obese as in nonobese asthmatics [5].”
BackgroundValidity and Reliability Evidence of the Asthma Control Test – Act in Greece
Grammatopoulou, E. P., Stavrou, N. A. M., Myrianthefs, P. M., Karteroliotis, K. E., Baltopoulos, G. J., BEHRAKIS, P. K., & Koutsouki, D. (2010) · Journal of Asthma · doi:10.3109/02770903.2010.529222 · Cited by 22
“As regards BMI, Greek patients with normal BMI had better asthma control compared to the overweight/obese, which is in accordance with previous studies (38, 47, 48).”
ResultPrevalence and Features of Asthma in Young Adults in Urban Areas of Argentina
Arias, S., Neffen, H. E., Bossio, J. C., Calabrese, C. A., Videla, A. J., Armando, G., & Antó, J. M. (2018) · Archivos de Bronconeumología · doi:10.1016/j.arbr.2018.01.014 · Cited by 22
“Excel 2013 and IBM SPSS Statistics 21 were used for the preparation of tables and statistical analysis.”
Metadata
- Authors
- Lavoie, K. L., Bacon, S. L., Labrecque, M., Cartier, A., & Ditto, B.
- Affiliations
- Université du Québec à Montréal (CA)
- Hôpital du Sacré-Cœur de Montréal (CA)
- McGill University (CA)
- Corresponding author
- Lavoie, Kim L.
- Venue
- Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 100
- Issue
- 4
- Pages
- 648-657
- ISSN
- 0954-6111 (ISSN-L)
- OpenAlex
- W2058669590
- Cited by
- 243
- References
- 50
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 7 · 2023: 8 · 2022: 9 · 2021: 8 · 2020: 12 · 2019: 8 · 2018: 12 · 2017: 13 · 2016: 8 · 2015: 11 · 2014: 20 · 2013: 19 · 2012: 21
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- asthma, obesity, body mass index, asthma control, asthma quality of life, asthma severity, overweight, Asthma Control Questionnaire, Asthma Quality of Life Questionnaire
- MeSH terms
- Adult, Aged, Asthma, Bronchodilator Agents, Canada, Cross-Sectional Studies, Female, Forced Expiratory Volume, Humans, Male, Middle Aged, Obesity, Quality of Life, Surveys and Questionnaires, Severity of Illness Index, Comorbidity, Body Mass Index
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