Omega-3 polyunsaturated fatty acids and bronchial inflammation in grass pollen allergy after allergen challenge
Open accessAbstract
Unlabelled RATIO: Asthma is a major public health problem, with bronchial inflammation as the therapeutic target. The role of dietary fish oil derived polyunsaturated fatty acids (PUFAs) in allergic inflammation is controversial. Most asthmatics suffer from mild disease and non-pharmacologic interventions are attractive. This study investigates the anti-inflammatory potential of nutritional PUFAs in an experimentally induced bronchial inflammation.Methods We examined 38 grass pollen allergic asthmatics and 19 controls. History of dietary PUFA intake was compared with levels of PUFAs in erythrocyte membranes, and stratified according to low (25th quartile; Q25) and high (75th quartile; Q75) ratios of omega-3 (n-3) to omega-6 (n-6) PUFAs as a surrogate for anti-inflammatory (Q75) or proinflammatory (Q25) effects. Bronchial inflammation was simulated with one-step inhalation of grass pollen. Bronchial response (exhaled nitric monoxide, eNO as surrogate for inflammation, decrease of FEV(1)) was correlated with levels of PUFAs in erythrocyte membranes.Results Ratios of n-3/n-6 PUFA were significantly lower in asthmatics than in healthy controls. Levels of eNO were significantly higher in Q25 asthmatics than in Q75 asthmatics (p = 0.040). There was a trend of higher bronchial hyperreactivity in Q25 asthmatics (median PD(20) 0.27 vs. 0.14; n.s.), induced by specific bronchial challenge with grass pollen (FEV(1) decrease 16.7 vs. 23.1%; n.s.).Conclusion When stratifying for erythrocyte membrane PUFA content as a surrogate for alimentary intake, we found mild effects on bronchial allergic inflammation. Future intervention studies with pharmacological PUFA doses appear suitable to clarify dietary PUFA role as an adjunctive intervention to the established treatment of asthma. ClinicalTrials.gov No. NCT00519740.
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The predominant endogenous cLA isomer is 9-cis, 11-trans-cLA, whereas plant-derived oils contain a racemic mixture of 9-cis, 11-trans and 10-trans, 12-cis-cLA.
“The predominant endogenous cLA isomer is 9-cis, 11-trans-cLA, whereas plant-derived oils contain a racemic mixture of 9-cis, 11-trans and 10-trans, 12-cis-cLA [28].”
From Nitrite and nitrate-dependent generation of anti-inflammatory fatty acid nitroalkenes (2015) · cites this paper as [28]
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- Authors
- Kitz, R., Rose, M. A., Schubert, R., Beermann, C., Kaufmann, A., Böhles, H. J., Schulze, J., & Zielen, S.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Rose, Markus A.
- Venue
- Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 104
- Issue
- 12
- Pages
- 1793-1798
- ISSN
- 0954-6111 (ISSN-L)
- OpenAlex
- W2085137895
- Cited by
- 44
- References
- 39
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 5 · 2019: 1 · 2017: 3 · 2016: 5 · 2015: 8 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NUMICO Research Germany
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Keywords
- omega-3 polyunsaturated fatty acids, omega-6 fatty acids, n-6/n-3 ratio, bronchial inflammation, allergic asthma, grass pollen allergy, allergen challenge, exhaled nitric oxide, airway hyperresponsiveness, erythrocyte membrane fatty acids, dietary fish oil, anti-inflammatory activity
- MeSH terms
- Adolescent, Adult, Bronchial Provocation Tests, Bronchitis, Female, Poaceae, Rhinitis, Allergic, Seasonal, Humans, Male, Middle Aged, Nitric Oxide, Surveys and Questionnaires, Spirometry, Fatty Acids, Omega-3, Dietary Supplements, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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