Effects of oral supplementation with bovine colostrum on the immune system of weaned piglets
Abstract
The aim of this study was to evaluate the influence of bovine colostrum supplementation on the immune system of weaned piglets in a context of a full ban of in-feed antibiotics. After weaning at 21 days, 24 outbred piglets were fed with a diet supplemented daily for three weeks with 0, 1 or 5 g of colostrum. Feed intake, growth performance, haematological parameters, and serum and local anti-colostrum immunoglobulin levels were examined. Lymphocytes from the blood, spleen, and gut-associated lymphoid were analysed for phenotype as well as for their ability to produce cytokines. The stimulation index (SI) of mononuclear cells from different organs was obtained after colostral or mitogenic stimulation. Feed intake, growth, and haematological parameters were not significantly affected by colostrum. Total serum IgA levels were increased after colostrum supplementation, with a transient decrease in total IgG. Local anti-colostrum immunization was observed in colostrum-fed piglets. The CD21+/CD3+ cells populations of the ileal Peyer's patch (iPP) were markedly affected. The SI of lymphocyte populations changed significantly whereas, naive blood lymphocytes were not stimulated in vitro in the presence of bovine colostrum, suggesting local anti-colostrum immunization and an absence of direct mitogenic effects of the colostrum. Both Th1 and Th2 cytokine production was present in the different organs of colostrum-fed piglets. Bovine colostrum especially stimulated iPP cells.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Bovine colostrum contains immune proteins that can modulate the immune system.
“While bovine colostrum not only contains a limited amount of milk oligosaccharides that may promote the growth of this particular bacteria [35, 36], it also contains an abundance of immune proteins, including immunoglobulins, lactoferrin and a range of cytokines, that can further modulate the microbiota [40] and the immune system [40–42].”
From Pilot study of probiotic/colostrum supplementation on gut function in children with autism and gastrointestinal symptoms (2019) · cites this paper as [42]
Cites
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692 · see citing works
Factors influencing the structure and function of the small intestine in the weaned pig: a review
Pluske, J. R., Hampson, D. J., & Williams, I. H. (1997) · Livestock Production Science · doi:10.1016/s0301-6226(97)00057-2 · Cited by 1,099 · see citing works
The acquisition of passive immunity in the new-born piglet
Rooke, J. A., & Bland, I. M. (2002) · Livestock Production Science · doi:10.1016/s0301-6226(02)00182-3 · Cited by 356 · see citing works
Growth factors and antimicrobial factors of bovine colostrum
Pakkanen, R., & Aalto, J. (1997) · International Dairy Journal · doi:10.1016/s0958-6946(97)00022-8 · Cited by 313 · see citing works
Tacket, C. O., Losonsky, G. A., Link‐Amster, H., Hoang, Y. K., Guesry, P. R., Hilpert, H., & Levine, M. M. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805123181904 · Cited by 292 · see citing works
Colostrum and its benefits: a review
Uruakpa, F. O., Ismond, M. A. H., & Akobundu, E. N. T. (2002) · Nutrition Research · doi:10.1016/s0271-5317(02)00373-1 · Cited by 222 · see citing works
Detection of cytokines in bovine colostrum
Hagiwara, K., Kataoka, S., Yamanaka, H., KIRISAWA, R., & Iwai, H. (2000) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(00)00213-0 · Cited by 179 · see citing works
Jensen, A. R., Elnif, J., Sangild, P. T., et al. (2001) · Journal of Nutrition · doi:10.1093/jn/131.12.3259 · Cited by 153 · see citing works
Bovine colostrum is a health food supplement which prevents NSAID induced gut damage
Playford, R. J., Floyd, D. N., Macdonald, C., Calnan, D. P., Adenekan, R. O., Johnson, W., Goodlad, R. A., & Marchbank, T. (1999) · Gut · doi:10.1136/gut.44.5.653 · Cited by 149 · see citing works
Morein, B., Abusugra, I. A., & Blomqvist, G. (2002) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(02)00078-8 · Cited by 132 · see citing works
Immunomodulatory properties of milk
Cross, M. L., & Gill, H. S. (2000) · British Journal Of Nutrition · doi:10.1017/s0007114500002294 · Cited by 122 · see citing works
Baumrucker, C. R., Hadsell, D. L., & Blum, J. W. (1994) · Journal of Animal Science · doi:10.2527/1994.722428x · Cited by 122 · see citing works
Mero, A. A., Miikkulainen, H., Riski, J., Pakkanen, R., Aalto, J., & Takala, T. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.4.1144 · Cited by 105 · see citing works
T helper cell differentiation in immune response
Reiner, S. L. (1995) · Current Opinion in Immunology · doi:10.1016/0952-7915(95)80111-1 · Cited by 104 · see citing works
Boyaka, P. N., Sfeir, R. M., Dubarry, M., Rautureau, M., & Tomé, D. (2004) · Journal of Nutrition · doi:10.1093/jn/134.2.403 · Cited by 98 · see citing works
Otani, H., & Hata, I. (1995) · Journal of Dairy Research · doi:10.1017/s0022029900031034 · Cited by 97 · see citing works
The mammary gland and neonate mucosal immunity
Salmon, H. (1999) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(99)00127-0 · Cited by 95 · see citing works
Xu, R., Mellor, D. J., Tungthanathanich, P., et al. (1992) · PubMed · Cited by 92 · see citing works
Stirling, C. M. A., Charleston, B., Takamatsu, H., Claypool, S. M., Lencer, W. I., Blumberg, R. S., & Wileman, T. E. (2005) · Immunology · doi:10.1111/j.1365-2567.2004.02121.x · Cited by 82 · see citing works
Raymond, C. R., & Wilkie, B. N. (2003) · Vaccine · doi:10.1016/j.vaccine.2003.08.026 · Cited by 75 · see citing works
Effects of purified bovine whey factors on cellular immune functions in ruminants
Wong, C. W., Seow, H. F., Husband, A. J., Regester, G. O., & Watson, D. L. (1997) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(96)05732-7 · Cited by 73 · see citing works
Cytokine activity in bovine mammary gland secretions during the periparturient period.
Sordillo, L. M., Redmond, M. J., Campos, M., et al. (1991) · PubMed · Cited by 68 · see citing works
Ebina, T., Ohta, M., Kanamaru, Y., et al. (1992) · Journal of Medical Virology · doi:10.1002/jmv.1890380209 · Cited by 67 · see citing works
Gómez, G., Phillips, O. T., & Goforth, R. (1998) · Journal of Animal Science · doi:10.2527/1998.7611 · Cited by 56 · see citing works
Bianchi, A. T. J., Scholten, J.-W., Leusen, B. H. W. M. M., et al. (1999) · Developmental & Comparative Immunology · doi:10.1016/s0145-305x(99)00026-9 · Cited by 56 · see citing works
Modulation of human humoral immune response through orally administered bovine colostrum
He, F., Tuomola, E., Arvilommi, H. S., et al. (2001) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2001.tb00504.x · Cited by 54 · see citing works
Modulation of immune responses by bovine β‐casein
WONG, C. W., Seow, H. F., LIU, A. H., Husband, A. J., Smithers, G. W., & Watson, D. L. (1996) · Immunology and Cell Biology · doi:10.1038/icb.1996.58 · Cited by 49 · see citing works
Observations on the Mode of Action of Normal Immunoglobulin at High Doses
Sundblad, A., Marcos, M. A. R., Malanchère, E., et al. (1994) · Immunological Reviews · doi:10.1111/j.1600-065x.1994.tb00860.x · Cited by 43 · see citing works
Effect of colostral ingestion on immunoglobulin-positive cells in calves
Aldridge, B. M., McGuirk, S. M., & Lunn, D. P. (1998) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(97)00158-x · Cited by 41 · see citing works
Immunoglobulin E suppression and cytokine modulation in mice orally tolerized to β‐lactoglobulin
PECQUET, PECQUET, PFEIFER, et al. (1999) · Immunology · doi:10.1046/j.1365-2567.1999.00678.x · Cited by 35 · see citing works
Suppression of Mitogenic Response of Peripheral Blood Mononuclear Cells by Bovine Mammary Secretions
Torre, P. M., & Oliver, S. P. (1989) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(89)79100-1 · Cited by 29 · see citing works
Yoshioka, Y., Kudo, S., Nishimura, H., Yajima, T., Kishihara, K., Saito, K., Suzuki, T., Suzuki, Y., Kuroiwa, S., & Yoshikai, Y. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.11.005 · Cited by 25 · see citing works
Mucosal immunology: overview and potential in the veterinary species
Hannant, D. (2002) · Veterinary Immunology and Immunopathology · doi:10.1016/s0165-2427(02)00051-x · Cited by 22 · see citing works
A Novel Immunosuppressive Factor in Human Colostrum
Mandalapu, P., Pabst, H. F., & Paetkau, V. H. (1995) · Cellular Immunology · doi:10.1006/cimm.1995.1067 · Cited by 21 · see citing works
Immunomodulation by Opioids from Dietary Casein (Exorphins)
Carr, R. I., WEBSTER, D., Sadi, D., et al. (1990) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1990.tb40500.x · Cited by 17 · see citing works
A bovine colostrum product in a weaner diet increases growth and reduces days to slaughter
Pluske, J. R., Pearson, G., Morel, P. C. H., et al. (1999) · Murdoch University Research Portal · Cited by 15 · see citing works
Damaraju, S., Hooton, J. W. L., Dost, A., & Paetkau, V. H. (1996) · Biochemistry and Cell Biology · doi:10.1139/o96-063 · Cited by 10 · see citing works
The acquisition of IgG from colostrum by piglets
Bland, I., Rooke, J. A., Bland, V. C., et al. (1999) · Proceedings of the British Society of Animal Science · doi:10.1017/s1752756200003446 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Sanctuary, M. R., Kain, J. N., Chen, S. Y., Kalanetra, K., Lemay, D. G., Rose, D. R., Yang, H. T., Tancredi, D. J., German, J. B., Slupsky, C. M., et al. (2019) · PLOS ONE · doi:10.1371/journal.pone.0210064 · Cited by 255 · see citing works
- Authors
- Boudry, C., Buldgen, A., Portetelle, D., Collard, A., Théwis, A., & Dehoux, J.-P.
- Affiliations
- Gembloux Agro-Bio Tech (BE)
- Centre d’Economie rurale (BE)
- UCLouvain (BE)
- Corresponding author
- Dehoux, J.-P.
- Venue
- Research in Veterinary Science
- Publisher
- Elsevier BV
- Published
- 2007-08
- Volume
- 83
- Issue
- 1
- Pages
- 91-101
- ISSN
- 0034-5288 (ISSN-L)
- OpenAlex
- W2000674293
- Cited by
- 34
- References
- 38
- Citations by year
- 2024: 2 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 1 · 2012: 3
- FWCI
- 4.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Research in Veterinary Science (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion)
- ORBi (University of Liège) (submittedVersion)
- Funders
- Waalse Gewest
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Health Sciences › Veterinary › Small Animals › Animal health and immunology
- Health Sciences › Veterinary › Small Animals › Veterinary medicine and infectious diseases
- Keywords
- bovine colostrum, weaned piglets, immune system, antibiotic alternatives, serum IgA, Peyer's patches, gut-associated lymphoid tissue, Th1/Th2 cytokines, lymphocyte stimulation index, growth performance, hematological parameters
- MeSH terms
- Administration, Oral, Animals, Animal Feed, Animal Nutritional Physiological Phenomena, Cattle, Cells, Cultured, Colostrum, Diet, Gene Expression Regulation, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Leukocytes, Mononuclear, Male, RNA, Messenger, Swine, Weaning, Cytokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
