Anthelmintic activity of Cocos nucifera L. on intestinal nematodes of mice
Abstract
In this study, we evaluated the anthelmintic activity of the liquid extracted from the bark of the green coconut (LBGC), as well as butanol extract obtained from LBGC, on mouse intestinal nematodes. Thirty-six naturally infected mice were distributed into six groups receiving the following treatments: Group I: 1000 mg/kg of LBGC; Group II: 2000 mg/kg of LBGC; Group III: 500 mg/kg of butanol extract; Group IV: 1000 mg/kg of butanol extract; Group V: 0.56 mg/kg febendazole; and Group VI: 3% dimethylsulfoxide. The chemical composition of the LBGC and its butanol extract was determined by phytochemical tests. A dose of 1000 mg/kg of butanol extract had 90.70% efficacy in reducing the mouse worm burden (p<0.05). Phytochemical tests revealed the presence of triterpens, saponnins and condensed tannins in the LBGC and butanol extracts. These results suggest that Cocos nucifera extracts may be useful in the control of intestinal nematodes.
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A butanol extract of coconut fiber recovered triterpenes, saponins, and condensed tannins.
“while a butanol extract recovered triterpenes, saponins, and condensed tannins (28).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
In egg hatching and larval development tests, 2.5 mg/mL LCCV and 10 mg/mL butanolic extract showed 100% ovicidal activity against Haemonchus contortus.
“In egg hatching and larval development tests, 2.5 mg/mL LCCV and 10 mg/mL butanolic extract showed 100% ovicidal activity.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
The liquid extract of the bark of the green coconut (LBGC) did not show antihelminthic activity against mouse nematodes compared with the negative control group (P>0.05).
“The LBGC did not show antihelminthic activity against the mouse nematodes compared with the negative control group (P>0.05).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
The butanol extract at 500 and 1000 mg/kg had mean efficacy of 62.72% and 98.36%, respectively (P<0.05) against mouse nematodes.
“However, the butanol extract at 500 and 1000 mg/kg had mean efficacy of 62.72% and 98.36%, respectively (P<0.05).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
Rats treated with both extracts had no histopathological changes related to toxicity, nor did weight gain differ between treated and control groups (P>0.05).
“Rats treated with both extracts had no histopathological changes related to toxicity, nor did weight gain differ between treated and control groups (P>0.05).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
In subchronic toxicity tests, rats treated with LBGC had significantly higher white blood cell, neutrophil, red blood cell, hematocrit, and platelet counts.
“In subchronic toxicity tests, the rats treated with LBGC had significantly higher white blood cell, neutrophil, red blood cell, hematocrit, and platelet counts.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
In subchronic and chronic toxicity tests, no hematological parameters differed significantly in the group treated with butanol extract (P>0.05).
“However, in the subchronic and chronic toxicity tests, no hematological parameters differed significantly in the group treated with butanol extract (P>0.05).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
When LMGC and butanol extract were administered intraperitoneally at doses of 500 and 700 mg/kg, no animal survived.
“In contrast, when LMGC and butanol extract were administered intraperitoneally at doses of 500 and 700 mg/kg, no animal survived.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
No acute lethal effects were observed in mice receiving a dose of 3000 mg/kg orally of either LMGC or butanol extract.
“No acute lethal effects were observed in mice receiving a dose of 3000 mg/kg orally of either extract.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
In the chronic toxicity test, the group treated with LBGC showed higher values for neutrophils, white blood cells, basophils, and platelets (P<0.05).
“In the chronic toxicity test, the group treated with LBGC showed higher values for neutrophils, white blood cells, basophils, and platelets (P<0.05).”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
Only triglycerides were higher (P<0.05) in the group treated with LBGC during the chronic toxicity test.
“Only triglycerides were higher (P<0.05) in the group treated with LBGC during the chronic toxicity test.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
Both extracts showed low toxicity for those parameters.
“In conclusion, both extracts showed low toxicity for those parameters.”
From Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review (2015) · cites this paper as [28]
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Cocos nucifera (L.) (Arecaceae): A phytochemical and pharmacological review
Lima, E. B. C., Sousa, C. N. S., Meneses, L. N., Ximenes, N. C., Santos Júnior, M. A., Vasconcelos, G. S., Lima, N. B. C., Patrocínio, M. C. A., Macedo, D., & Vasconcelos, S. M. M. (2015) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20154773 · Cited by 295 · see citing works
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Thakur, M., Pant, K., & Nanda, V. (2020) · Antioxidants in Vegetables and Nuts - Properties and Health Benefits · doi:10.1007/978-981-15-7470-2_19 · Cited by 5 · see citing works
- Authors
- Costa, C. T. C., Bevilaqua, C. M. L., Morais, S. M., Camurça-Vasconcelos, A. L. F., Maciel, M. V., Braga, R. R., & Oliveira, L. M. B.
- Affiliations
- Universidade Estadual do Ceará (BR)
- Corresponding author
- Bevilaqua, C.M.L.
- Venue
- Research in Veterinary Science
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 88
- Issue
- 1
- Pages
- 101-103
- ISSN
- 0034-5288 (ISSN-L)
- OpenAlex
- W1985830643
- Cited by
- 42
- References
- 13
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 16 · 2022: 4 · 2021: 2 · 2020: 4 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 1 · 2014: 1
- FWCI
- 0.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Research in Veterinary Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Embrapa Agroindústria Tropical
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Physical Sciences › Chemistry › Inorganic Chemistry › Coconut Research and Applications
- Keywords
- Cocos nucifera, anthelmintic activity, intestinal nematodes, n-butanol extract, natural anthelmintics, worm burden, triterpenoids, saponins, proanthocyanidins, phytochemical composition
- MeSH terms
- Animals, Anthelmintics, Cocos, Dose-Response Relationship, Drug, Intestines, Phytotherapy, Nematoda, Nematode Infections, Plant Extracts, Rodent Diseases, Plant Bark, Mice
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