The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Soluble guanylate cyclase
Abstract
Soluble guanylate cyclase (sGC) is a mammalian nitric oxide (NO) sensor. When NO binds to the sGC heme, its GTP cyclase activity markedly increases, thus generating cyclic GMP, which serves to regulate several cell signaling functions. A good deal is known about the kinetics and equilibrium of binding of NO to sGC, leading to a proposed multistep mechanism of sGC activation that involves at least two NO-binding sites. The crystal structure of a member of a recently discovered family of prokaryotic sGC homologues has provided important insights into structure-function relationships within the sGC family of proteins.
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In the citing paper
“The reaction is observed in the three NOS isoforms (750, 973, 1034).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [750]
In the citing paper
“Initial reports indicated that nNOS had the ability to produce superoxide in a reaction dependent on NADPH and Ca2+/CaM (750).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [750]
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Metadata
- Authors
- Poulos, T. L.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Poulos, Thomas L
- ORCID
- Poulos, Thomas L
- Venue
- Current Opinion in Structural Biology
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 16
- Issue
- 6
- Pages
- 736-743
- ISSN
- 0959-440X (ISSN-L)
- OpenAlex
- W2074306377
- Cited by
- 129
- References
- 29
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 6 · 2022: 9 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 14 · 2013: 10 · 2012: 12
- FWCI
- 0.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Structural Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Hemoglobin structure and function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Keywords
- soluble guanylate cyclase, nitric oxide sensor, cyclic GMP, crystal structure, structure-function relationship, heme
- MeSH terms
- Animals, Enzyme Activation, Guanylate Cyclase, Heme, Kinetics, Ligands, Models, Molecular, Nitric Oxide, Prokaryotic Cells, Recombinant Proteins, Solubility, Signal Transduction, In Vitro Techniques
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