Structure and Regulation of Soluble Guanylate Cyclase

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Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G sα ·GTPγS

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NO-independent stimulators and activators of soluble guanylate cyclase: discovery and therapeutic potential

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Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and Carbon Monoxide and Spectral Characterization of the Ferrous and Ferric States

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Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue

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NO-independent regulatory site on soluble guanylate cyclase

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Structure and Signaling Mechanism of Per-ARNT-Sim Domains

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ON THE USE OF NITRITE OF AMYL IN ANGINA PECTORIS.

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YC-1, a novel activator of platelet guanylate cyclase

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Structure of the adenylyl cyclase catalytic core

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Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.

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Sensitizing soluble guanylyl cyclase to become a highly CO‐sensitive enzyme.

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Methylene blue inhibits coronary arterial relaxation and guanylate cyclase activation by nitroglycerin, sodium nitrite, and amyl nitrite

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Physiology and Pathophysiology of Vascular Signaling Controlled by Cyclic Guanosine 3′,5′-Cyclic Monophosphate–Dependent Protein Kinase

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NO‐ and haem‐independent activation of soluble guanylyl cyclase: molecular basis and cardiovascular implications of a new pharmacological principle

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Spectral and Kinetic Studies on the Activation of Soluble Guanylate Cyclase by Nitric Oxide

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Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance

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Neurons Detect Increases and Decreases in Oxygen Levels Using Distinct Guanylate Cyclases

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Crystal structure of an oxygen-binding heme domain related to soluble guanylate cyclases

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Mutation of His-105 in the beta 1 subunit yields a nitric oxide-insensitive form of soluble guanylyl cyclase.

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Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase

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NO and CO differentially activate soluble guanylyl cyclase via a heme pivot‐bend mechanism

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NO activation of guanylyl cyclase

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Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation

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Exchange of Substrate and Inhibitor Specificities between Adenylyl and Guanylyl Cyclases

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Nitric oxide signaling: no longer simply on or off

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NITRO-GLYCERINE AS A REMEDY FOR ANGINA PECTORIS.

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Experience-Dependent Modulation of C. elegans Behavior by Ambient Oxygen

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Functional properties of a naturally occurring isoform of soluble guanylyl cyclase

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Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure.

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LY 83583 interferes with the release of endothelium-derived relaxing factor and inhibits soluble guanylate cyclase.

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Activation of purified soluble guanylate cyclase by protoporphyrin IX.

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Guanylyl Cyclase/PSD-95 Interaction

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Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system

Mergia, E. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27657 · Cited by 198 · see citing works

Upregulation of Phosphodiesterase 1A1 Expression Is Associated With the Development of Nitrate Tolerance

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Femtomolar Sensitivity of a NO Sensor from Clostridium botulinum

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A molecular basis for NO selectivity in soluble guanylate cyclase

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Ancient conserved domains shared by animal soluble guanylyl cyclases and bacterial signaling proteins

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A new form of guanylyl cyclase is preferentially expressed in rat kidney

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Expression of soluble guanylyl cyclase

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Unprecedented proximal binding of nitric oxide to heme: implications for guanylate cyclase

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Identification of Residues Crucially Involved in the Binding of the Heme Moiety of Soluble Guanylate Cyclase

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Identification of Histidine 105 in the β1 Subunit of Soluble Guanylate Cyclase as the Heme Proximal Ligand

Zhao, Y., Schelvis, J. P. M., Babcock, Ǵ., & Marletta, M. A. (1998) · Biochemistry · doi:10.1021/bi972686m · Cited by 161 · see citing works

Molecular cloning and expression of a new α‐subunit of soluble guanylyl cyclase Interchangeability of the α‐subunits of the enzyme

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Expression of soluble guanylate cyclase activity requires both enzyme subunits

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Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion.

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Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses

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Binding of Nitric Oxide and Carbon Monoxide to Soluble Guanylate Cyclase As Observed with Resonance Raman Spectroscopy

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Calcium-dependent membrane association sensitizes soluble guanylyl cyclase to nitric oxide

Zabel, U., Kleinschnitz, C., Oh, P., Nedvetsky, P. I., Smolenski, A., Müller, H., Kronich, P., Kügler, P., Walter, U., Schnitzer, J. E., et al. (2002) · Nature Cell Biology · doi:10.1038/ncb775 · Cited by 151 · see citing works

Soluble Guanylate Cyclases Act in Neurons Exposed to the Body Fluid to Promote C. elegans Aggregation Behavior

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Cinaciguat (BAY 58–2667) Improves Cardiopulmonary Hemodynamics in Patients With Acute Decompensated Heart Failure

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Purifieation of a Soluble, Sodium‐Nitroprusside‐Stimulated Guanylate Cyclase from Bovine Lung

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Tonic and acute nitric oxide signaling through soluble guanylate cyclase is mediated by nonheme nitric oxide, ATP, and GTP

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Replacement of the Proximal Ligand of Sperm Whale Myoglobin with Free Imidazole in the Mutant His-93.fwdarw.Gly

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A nitric oxide/cysteine interaction mediates the activation of soluble guanylate cyclase

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Reversible inactivation of guanylate cyclase by mixed disulfide formation.

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Functional Domains of Soluble Guanylyl Cyclase

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Human recombinant soluble guanylyl cyclase: Expression, purification, and regulation

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HEME-LIGAND TUNNELING IN GROUP I TRUNCATED HEMOGLOBINS

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Tissue Distribution of the Human Soluble Guanylate Cyclases

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Purification of soluble guanylate cyclase from rat lung.

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Localization of the Heme Binding Region in Soluble Guanylate Cyclase†

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Synergistic activation of soluble guanylate cyclase by YC-1 and carbon monoxide: implications for the role of cleavage of the iron-histidine bond during activation by nitric oxide

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Effects of Cyclic GMP on Smooth Muscle Relaxation

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Probing the Function of Heme Distortion in the H-NOX Family

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Nitroglycerin-Induced S-nitrosylation and Desensitization of Soluble Guanylyl Cyclase Contribute to Nitrate Tolerance

Sayed, N., Kim, D. D., Fioramonti, X., Iwahashi, T., Durán, W. N., & Beuve, A. (2008) · Circulation Research · doi:10.1161/circresaha.108.175133 · Cited by 115 · see citing works

H-NOX–mediated nitric oxide sensing modulates symbiotic colonization by Vibrio fischeri

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Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide

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Sub-second Kinetics of the Nitric Oxide Receptor, Soluble Guanylyl Cyclase, in Intact Cerebellar Cells

Bellamy, T. C., & Garthwaite, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006677200 · Cited by 111 · see citing works

Membrane guanylyl cyclase receptors: an update

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The function of NO-sensitive guanylyl cyclase: What we can learn from genetic mouse models

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Nitric Oxide–Independent Vasodilator Rescues Heme-Oxidized Soluble Guanylate Cyclase From Proteasomal Degradation

Meurer, S., Pioch, S., Pabst, T., Opitz, N., Schmidt, P. M., Beckhaus, T., Wagner, K., Matt, S., Gegenbauer, K., Geschka, S., et al. (2009) · Circulation Research · doi:10.1161/circresaha.109.198234 · Cited by 107 · see citing works

Differential Inhibition of Adenylyl Cyclase Isoforms and Soluble Guanylyl Cyclase by Purine and Pyrimidine Nucleotides

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Crystal structure of the guanylyl cyclase Cya2

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Aldosterone Increases Oxidant Stress to Impair Guanylyl Cyclase Activity by Cysteinyl Thiol Oxidation in Vascular Smooth Muscle Cells

Maron, B. A., Zhang, Y., Handy, D. E., Beuve, A. V., Tang, S., Loscalzo, J., & Leopold, J. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m809460200 · Cited by 101 · see citing works

Dissociation of Nitric Oxide from Soluble Guanylate Cyclase

Kharitonov, V. G., Russwurm, M., Magde, D., Sharma, V. S., & Koesling, D. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7470 · Cited by 101 · see citing works

Structure of Cinaciguat (BAY 58–2667) Bound to Nostoc H-NOX Domain Reveals Insights into Heme-mimetic Activation of the Soluble Guanylyl Cyclase

Martin, F., Baskaran, P., Ma, X., Dunten, P., Schäfer, M., Stasch, J., Beuve, A. V., & van den Akker, F. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.111559 · Cited by 99 · see citing works

Ligand Selectivity of Soluble Guanylyl Cyclase

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Ligand discrimination in soluble guanylate cyclase and the H-NOX family of heme sensor proteins

Boon, E. M., & Marletta, M. A. (2005) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2005.08.015 · Cited by 96 · see citing works

Mechanisms of ligand discrimination by heme proteins

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Regeneration of the Ferrous Heme of Soluble Guanylate Cyclase from the Nitric Oxide Complex: Acceleration by Thiols and Oxyhemoglobin

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Pharmacological Activation of Soluble Guanylate Cyclase Protects the Heart Against Ischemic Injury

Korkmaz, S., Radovits, T., Barnucz, E., Hirschberg, K., Neugebauer, P., Loganathan, S., Veres, G., Páli, S., Seidel, B., Zöllner, S. K., et al. (2009) · Circulation · doi:10.1161/circulationaha.109.870774 · Cited by 95 · see citing works

PAS-mediated Dimerization of Soluble Guanylyl Cyclase Revealed by Signal Transduction Histidine Kinase Domain Crystal Structure

Ma, X., Sayed, N., Baskaran, P., Beuve, A. V., & van den Akker, F. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706218200 · Cited by 94 · see citing works

Functions of Conserved Cysteines of Soluble Guanylyl Cyclase

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Smooth Muscle–Specific Deletion of Nitric Oxide–Sensitive Guanylyl Cyclase Is Sufficient to Induce Hypertension in Mice

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The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase

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Interaction of Soluble Guanylate Cyclase with YC-1: Kinetic and Resonance Raman Studies

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Nitric Oxide Activates the β2 Subunit of Soluble Guanylyl Cyclase in the Absence of a Second Subunit

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Expression and Characterization of the Catalytic Domains of Soluble Guanylate Cyclase:  Interaction with the Heme Domain

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Shewanella oneidensis MR-1 H-NOX Regulation of a Histidine Kinase by Nitric Oxide

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